Why anyone will want to get out of taking metformin? - Page 2

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Why anyone will want to get out of taking metformin? - Page 2


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Old 07-15-2012, 19:29   #11
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Originally Posted by Darbro View Post
The efficacy of this drug is convincing and I would be inclined to listen to your physician rather than pharmacophobes and take this medicine. This is particularly true if you've found through your own testing of bg that it has been helpful. While there is risk in taking any medicine because it is never known in it's entirety what the effects will be, the same can be said for virtually any hard-line treatment strategy. For many type 2's the insulin resistance is severe enough that dietary restriction may be insufficient to reduce bg to safe levels because the liver continues to make its own glucose by a process known as gluconeogenesis. While several therapeutic benefits have been reported for metformin, the most well understood is it's ability to reduce the capacity of the liver to carry out gluconeogenesis.

Dabro, I was taking metformin and other medicine for a long while (6 months) but now with a load of weight loss and a low carb diet I have numbers in the following range.
Fastings in the 80's and post meals <100. I spend all of my day under 100 and very rarely go upto a 105.
I therefore concluded that I do not need Metformin and also because I was sometimes seeing numbers in the high 60s. My doctor agreed and I have been without the med for 5 months now.

If my control spoils I will most likely agree to taking metformin and raise the dose to as much is required. My next line of drugs will be insulin. I'd rather take the most "natural" thing than any other meds

Many people, including me, think of being "med free" as a victory of sorts. If not others atleast I felt that way. But at the same time I also believe medicines and insulin are your friends and you should be talking them if you need them.

All meds have a side effect, we need to do a benefit versus side effect analysis. I however feel that Metformin is the safest of them all.




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Old 07-15-2012, 19:40   #12
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Well I was following a ketonic diet, I exercise everyday and had my weight under control since I began taking notice of my pre-diabetes(which I probably have from much longer) with a BMI of 21 but my numbers just were still getting worst. Since taking the metformin my numbers have been on the non diabetic range and especially postprandial which were getting worse by the years. So for me is a no brainer better sugar control and preventing any high blood sugar damage trumps all the others concern. Metformin has been god send, if it stops working then insulin will be my next step since my father had diabetes and I know from personal experience that blood sugar control is top priority.

I had read about the B-12 and the testosterone which also a problem with obesity and diabetes. I have no problem with them and they can be easily tested and corrected with sub-lingual b-12 or injection in case of testosterone.

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Old 07-15-2012, 19:58   #13
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jwags: One thing I'm curious about is the relationship between Met and ketosis. It seems plausible that since liver glycogen depletion is generally regarded as a prerequisite to ketosis and Met prevents that, does it also prevent true ketosis? Have you considered getting hold of the free blood ketone meter so we could find out?
I have been on 1000mg of met (500 am/500pm) since dx in Feb of this year. I am very lc/hf and pretty sure I am in ketosis. I have used the sticks and always am in the darkest 3 areas. I recently got my Nova Max meter and my ketone readings are in the low to mid 3's. Yesterday fasting was 3.6 and bedtime was 3.3. My ketogenic ratios are almost all over 2, with a couple 3's and a 4. My bg readings are very good, nothing over 110 and fastings in the 70's to 90's. I am not losing weight however. Do you think I am in true ketosis??

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Old 07-16-2012, 00:16   #14
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Originally Posted by smorgan

I'm not suggesting you follow my ideas, just expressing them. I think something important about doing LC/HF is that standards for morning numbers needs to change. As far as I'm concerned, anything acceptable as a post-meal number is acceptable as a morning number as long as overall averages and A1C are in a good range.

Think of it as a "delayed" meal. Because of all the changes in metabolism, this glucose was stored and dumped in the AM. Dumping liver glycogen on a ketogenic diet is a GOOD thing, not a bad one. I want it dumped, gone and kept as low as possible.

Peter of Hyperlipid has an A1C in the 4's and average waking numbers of 120. I think this is pretty clearly a non-issue.

When attempting to go down a LC/HF or ketogenic path, I wouldn't make any decisions based on mornings readings as long as they are under 130 and A1C is OK. Certainly not returning to Met as it could work against the strategy as a whole.
I was wondering about what happened if BG goes up and you were in ketosis. Mine seems to stay wherever it is without much change unless I goof up and get too much carbs or proteins. If I am in 80s I stay there, if 90s I stay there if 100s I stay there. Going back down seems to be a slow process. I don't normally see a big BG drop from exercise (walking anyway), usually small but steady.

I guess I need work my brain more when I get a spike to use up the BG. Hmm if I would do that before I spike that may eliminate spikes all together.

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Old 07-16-2012, 00:42   #15
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In previous post I said usually. For this week I am having unusual movements in BG.

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Old 07-16-2012, 13:29   #16
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Its not something that is heavily prescribed in the countries where I have lived recently i.e. Europe and now Australia
Even if it was though Im unsure whether i would go for it. I worry about the amount of drugs already pumping through my system i.e. insulin and hypothyroid treatment.

Im one of those strange ones that will try and sit out a headache if I can


I eat low carb to try and reduce the amount of insulin I use (to a sensible extent) and I'm prepared to work hard, exercise etc. to try and use my natural resources rather than just treat it.

And my last HBA1C was 5.9

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Old 07-16-2012, 14:55   #17
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Its not something that is heavily prescribed in the countries where I have lived recently i.e. Europe and now Australia
Even if it was though Im unsure whether i would go for it. I worry about the amount of drugs already pumping through my system i.e. insulin and hypothyroid treatment.

Im one of those strange ones that will try and sit out a headache if I can


I eat low carb to try and reduce the amount of insulin I use (to a sensible extent) and I'm prepared to work hard, exercise etc. to try and use my natural resources rather than just treat it.

And my last HBA1C was 5.9
Metformin is typically only useful for T2s addressing their BG with carb reduction. it is unlikely to be of much use to T1s unless they are "dual" - T1s with insulin resistance. This issue of Met helping with IR is unproven ("disproven" in many studies), so it may be an individual thing where some people get this benefit while others do.

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Old 07-20-2012, 04:27   #18
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I don't know about anyone else but I just don't like putting chemicals in my body if it can be avoided. I've adopted a diet and have had great success. I've lost 30lbs over the last 6 months, gone from a dress size of 9 down to a 5, and my sugar levels are now between 4.8 and 6.9mmol. My doctor has changed my Meformin from 1000mg x 2 daily down to 225mg once daily and I've been successful in eliminating some of that over the last couple of weeks while keeping my levels in the normal range. My goal is to become medication free while keeping normal blood sugar levels and I Believe I will get there.


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I read some are trying to get out of taking metformin, I donít understand. Maybe there is something I donít know? Why anyone will want to get out of taking metformin? I had to battle my doctor for the prescription because my A1C was only 6.1 even do I was low carb for a few years. It took me a while to get adapted, I needed berberine to control the diarrhea and mint teas for the nausea. Why once adapted will anyone want to stop taking it. It have read so many good thinks about it and has so many health benefits some Drs and Life Extension Magazine recommend them for anyone over 40 as an anti-aging, anti-cancer supplement. They say blood sugar regulation goes down with age and that everyone over 40 years can benefits from metformin, since most are mildly diabetics.

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Old 07-20-2012, 05:10   #19
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My doctor has changed my Meformin from 1000mg x 2 daily down to 225mg once daily
I'm puzzled about this because to my knowledge, 500 mg is the smallest dosage. How do you take 225 mg?

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Old 07-20-2012, 05:16   #20
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Probably by cutting the pill in half that would get you close to half a dose

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