Is Metabolic Syndrome caused by high fructose, low fat, low cholesterol diet?

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Is Metabolic Syndrome caused by high fructose, low fat, low cholesterol diet?


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Old 02-06-2012, 12:05   #1
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Default Is Metabolic Syndrome caused by high fructose, low fat, low cholesterol diet?

With my apologies if this has been posted before


Archives of Medical Science. 2011 February; 7(1): 820.

Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?

Stephanie Seneff, Glyn Wainwright, and Luca Mascitelli.

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Abstract
The metabolic syndrome (MetS) is manifested by a lipid triad which includes elevated serum triglycerides, small LDL particles, and low high-density lipoprotein (HDL) cholesterol, by central obesity (central adiposity), insulin resistance, glucose intolerance and elevated blood pressure, and it is associated with an increased risk of type 2 diabetes and coronary heart disease. We have developed a new hypothesis regarding MetS as a consequence of a high intake in carbohydrates and food with a high glycemic index, particularly fructose, and relatively low intake of cholesterol and saturated fat. We support our arguments through animal studies which have shown that exposure of the liver to increased quantities of fructose leads to rapid stimulation of lipogenesis and accumulation of triglycerides. The adipocytes store triglycerides in lipid droplets, leading to adipocyte hypertrophy. Adipocyte hypertrophy is associated with macrophage accumulation in adipose tissue. An important modulator of obesity-associated macrophage responses in white adipose tissue is the death of adipocytes. Excess exposure to fructose intake determines the liver to metabolize high doses of fructose, producing increased levels of fructose end products, like glyceraldehyde and dihydroxyacetone phosphate, that can converge with the glycolytic pathway. Fructose also leads to increased levels of advanced glycation end products. The macrophages exposed to advanced glycation end products become dysfunctional and, on entry into the artery wall, contribute to plaque formation and thrombosis.
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Old 02-06-2012, 13:31   #2
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Holy cats, that is one of the best papers I have read about metabolic syndrome! Great find!

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Old 02-06-2012, 14:19   #3
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Looks good ... but how was it received? I will look to see who else has cited it!

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Old 02-06-2012, 15:01   #4
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I'm taking this to FaceBook! That may be the only way my kids will read it!




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Old 02-06-2012, 15:33   #5
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Quote:
Originally Posted by fgummett View Post
With my apologies if this has been posted before


Archives of Medical Science. 2011 February; 7(1): 820.

Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?

Stephanie Seneff, Glyn Wainwright, and Luca Mascitelli.



Here is the full text...
I noticed they mentioned "insulin resistance" and "glucose intolerance" as two separate things. That would seem to match with my theories of excessive glucose metabolism being the start and cause of everything. Does anyone know if they really have two different and accepted definitions and if so, what are they?

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Old 02-06-2012, 15:50   #6
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Good article. I think the human body was meant to be a two way street. Accumulate fat thru CHO consumption but then use that fat as a means of a fuel source. But if the street is only one way, its like filling a balloon, it only can hold so much.

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