Intestinal bacterium Akkermansia curbs obesity

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Start Here > Diabetes Forum Lounge

Diabetes Forum Lounge The Diabetes Forum lounge is the more social area of the community. Please feel free to drop in, and discuss anything that’s on your mind. Use this area for off topic discussions, making friends and being social.


Intestinal bacterium Akkermansia curbs obesity


Closed Thread
 
Shared Thread Thread Tools
Old 05-16-2013, 11:54   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Intestinal bacterium Akkermansia curbs obesity

Intestinal bacterium Akkermansia curbs obesity

A dominant and useful bacterium called Akkermansia muciniphila is present in the intestinal system of all humans, from babies to the elderly. This microorganism is found in the intestinal mucus layer that protects against intruders. Even more remarkable is that this bacterium has a favourable effect on the disrupted metabolism associated with obesity. Prof. Patrice Cani from Brussels and Prof. Willem de Vos from Wageningen University, together with their colleagues, published these findings in the scientific journal Proceedings of the National Academy of Sciences (PNAS) on 13 May. They see potential in deploying Akkermansia bacteria to further understand and treat obesity and medical consequences.

Obesity and type 2 diabetes are both characterised by symptoms including inflammation, changes in the composition of the intestinal bacteria and the disruption of the natural barrier in the intestines. Ten years ago, researchers at the Laboratory of Microbiology at Wageningen University, part of Wageningen UR, discovered the bacterium Akkermansia muciniphila (named after the Wageningen microbial ecologist Dr Antoon Akkermans, 1941-2006), which was able to grow in the mucus layer of the intestines. The bacteria were apparently present in large numbers in humans (and rodents) that were not overweight. Fewer were present in humans and rodents with inflammations or obesity. The microbiologists at Université Louvain in Brussels and their Wageningen colleagues wondered what the role of this bacterium could be.

(snip)

In the article that appeared on 13 May in the journal Proceedings of the National Academy of Sciences of the United States of America, the research team concluded that the bacteria are less frequent in mice with induced obesity and with type 2 (adult-onset) diabetes. Furthermore, administering rather indigestible fibres such as oligofructose, known for its advantageous effect on intestinal biota, resulted in a recovery of the Akkermansia population in mice. The presence of the bacteria strengthens the intestinal barrier and is also inversely correlated with weight increase (fat storage), inflammation reactions in fatty tissues and insulin resistance. However, is there also a causal relationship between the favourable developments and the occurrence of Akkermansia bacteria?

kantim is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
The science of obesity: what do we really know about what makes us fat? kantim Diabetes Diet and Nutrition 2 04-18-2013 17:55
Obesity without the health problems? There could be a way kantim Diabetes News 1 04-05-2013 16:24
Tax on Obesity???? jwags Diabetes Forum Lounge 9 05-19-2012 14:46
Insulin and Obesity scottietwenty3 Diabetes News 22 02-16-2012 07:24
This 15 year old may die from obesity Richard157 Diabetes in children 3 12-25-2008 07:46

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 14:20.




Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.