O My Liver

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  • 8 Post By Rad Warrier
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O My Liver


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Old 10-06-2013, 17:14   #1
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Default O My Liver

'O My Liver' is a term of endearment in my mother tongue almost equivalent to English 'O My Sweetheart'. For my forefathers, liver was a bit more important than the heart, it appears. . In Hindi, 'jigri dost', literally 'livery friend', is a fast friend. In fact, Greek 'hepar' (from which English adjective 'hepatic' is derived), Sanskrit 'yakrit' and Persian 'jigar' are all cognates going back to a Proto Indo-European word *yekwr- meaning liver. So much for the liver. My liver is all screwed up and that is why I am a type 2 diabetic .

The more I read scientific papers relating to diabetes, the more I find that the liver plays a larger role than pancreas in most varieties of type 2 diabetes. Hepatic insulin resistance leading to over production of glucose by the liver seems to be more of a problem for type 2 diabetics than insufficiency of insulin production by pancreas. If the diabetes isn't far gone (i.e. hasn't progressed too much), pancreatic insulin production (though less and slower than in non-diabetics) can cover for a normal insulin challenge (i.e. for a normal meal eaten.) Some studies have revealed that the absorption of glucose by muscle cells is not much different in the case of an average type 2 diabetic compared to an average non-diabetic. In other words, muscle insulin resistance is not much higher for an average type 2 diabetic than in the case of a non-diabetic. But hepatic (i.e., liver) insulin resistance is significantly higher for the diabetic. The liver doesn't properly hear the signal from the pancreas to stop glucose production. For the type 2 diabetic, the liver dumps far too much glucose into the blood stream than for a non-diabetic both in the post-meal and in the fasted state.

The average type 2 diabetic is also prone to accumulation of fat in the liver. So, the central obesity you see in diabetics may not be all visceral fat. Some of it could be fatty liver.

Oh my liver!

Regards,
Rad

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Old 10-06-2013, 19:48   #2
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I think you've got it pretty much exactly right. There are three types of insulin resistance, each with their own ramifications: 1) liver, 2) fat cells, and 3) muscle. I'm not sure if we know for sure how they are distributed in the T2 population but liver IR does seem to be critical.

As for fatty liver, recent evidence seems clear that it relates directly to excessive glucose from diet, especially from carbohydrates.

All of this is why my particular solution to diabetes - which especially covers hepatic insulin resistance - is to deplete the glycogen stores of the liver as low as possible. This protects against the harm of liver insulin resistance. It no longer matters if it is not "listening" to insulin, which should shut down liver glucose production at its very first appearance, since it just doesn't have stores to "dump" from!

An ultra-fat diet (which by definition means both low-carb and reasonable protein) reverses fatty liver or doesn't allow it to happen in the first place. If that seems hard to believe, just remember what they stuff down the throats of geese to make them have fatty livers! Hint: It ain't fat! Maintained over time, this reduces the glycogen stores drastically and re-trains cells (most of them) to use other fuels besides glucose. Thus, if there is a shortage of insulin as well, it is rendered a non-issue. Metabolizing FFAs and ketones in muscle, heart and elsewhere - and more importantly fueling the brain on ketones - requires no insulin at all.

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Old 10-07-2013, 10:32   #3
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Fascinating, Mr. Warrior!

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Old 10-07-2013, 13:22   #4
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The French also believe the liver is the seat of all emotion. One does wonder if it indeed came from a PIE belief. My father's Y-chromosome haplogroup is R1a1 ("Old Northwest" branch, a very old one, indeed) and R1a1 is also held in common with many northern Indian men. So I have studied the origins of PIE language -- cool stuff!
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Old 10-07-2013, 14:47   #5
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Swahili, too. When someone's words are very hurtful, the saying is, "His words cut his liver." Also, when someone has extreme envy and is angry that others have what he/she wants, the expression is, "His liver is bursting."

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Old 10-08-2013, 02:35   #6
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This is extremely interesting, considering I have an appointment next week with a gastroenterologist due to fatty liver and LFTs that spiked.

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