Your brain on ketones

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Your brain on ketones


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Old 02-19-2014, 06:13   #1
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Default Your brain on ketones

An article I found interesting by a psychiatrist on you brain on ketones. How a high-fat diet can help the brain work better.

Your Brain On Ketones | Psychology Today

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Old 02-19-2014, 12:02   #2
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Old 02-19-2014, 12:24   #3
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Wow

I knew most of the information. But she structured and extrapolated in some really fascinating (and potentially health-important) ways. Thank you!

"I was taught that glucose was "clean" and ketones were "smokey." That glucose was clearly the preferred fuel for our muscles for exercise and definitely the key fuel for the brain. Except here's the dirty little secret about glucose - when you look at the amount of garbage leftover in the mitochondria, it is actually less efficient to make ATP from glucose than it is to make ATP from ketone bodies! A more efficient energy supply makes it easier to restore membranes in the brain to their normal states after a depolarizing electrical energy spike occurs, and means that energy is produced with fewer destructive free radicals leftover."

Made me think of those little sirtuin enzymes hard at work dusting and sweeping inside our cells/mitochondria.

I like it when what appear to be random pieces of information fit together...makes me hope may actually all be working on the same puzzle.

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Old 02-19-2014, 15:11   #4
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Originally Posted by gotsomeold View Post
Wow

I knew most of the information. But she structured and extrapolated in some really fascinating (and potentially health-important) ways. Thank you!

"I was taught that glucose was "clean" and ketones were "smokey." That glucose was clearly the preferred fuel for our muscles for exercise and definitely the key fuel for the brain. Except here's the dirty little secret about glucose - when you look at the amount of garbage leftover in the mitochondria, it is actually less efficient to make ATP from glucose than it is to make ATP from ketone bodies! A more efficient energy supply makes it easier to restore membranes in the brain to their normal states after a depolarizing electrical energy spike occurs, and means that energy is produced with fewer destructive free radicals leftover."

Made me think of those little sirtuin enzymes hard at work dusting and sweeping inside our cells/mitochondria.

I like it when what appear to be random pieces of information fit together...makes me hope may actually all be working on the same puzzle.
In other words, regarding the paragraph you quoted from the article, the truth is pretty much the diametric OPPOSITE of everything they said - AGAIN!

Glucose is the "smoky" fuel. It produces all kinds of toxic by-products which various enzymatic processes within the cell have to clean up, e.g., methylglyoxal. Ketones are the "clean" fuel which produces no such toxins.

My personal belief is that it is precisely the breakdown of the enzymatic after-glucose clean-up processes which is at the root of diabetes.

I started a thread here some time ago which quotes in detail from a variety of studies on the matter.

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Old 02-19-2014, 15:38   #5
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I suspect it would be most accurate to say, 'where there is fire there is ash' and neither glucose nor ketones are clean burns.

Having said that, I find the idea that many of our problems originate in the ash & detritus of glucose utilization very appealing.

Hmmm, a few months ago I wrote quite a diatribe on another forum about how our bodies natural clean-up system appears to be several of the sirtuin enzymes. SIRT1 specifically cleans up, rebuilds, or trashes cellular matter (does not go down to the mitachondria).

And SIRT1 is activated by Ketosis...which, in turn, is activated by eating LC or LCHF, or intermittent fasting, or chugging MCTs.

Therefore, in a world of never go hungry and always eat balanced meals (and, avoid saturated fats) we have created a world where cellular clean up almost literally does not happen. Approx 7 million cells die each day and just hang around stagnating - nothing comes and sweeps them away. Who knows how many cells are damaged by glucose ash, free radicals, whatever and the repairman only gets activated if the body happens to fall into ketosis for a few hours in the early morning - after it has finished burning the carbs eaten for dinn-dinn last night.

Salim, if this theory is trending in the right direction, it explains why some of my D friends can eat carbs and have low stable BG as long as they fast regularly ... and it underscores why LCHF is so frequently amazingly successful in lowering and regulating even BG that has been out of control for years and years.

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8/26/14 HbA1c 5.5
avg BG: 90 - 95 before meals, 100 - 110 one hour PP, 95 2 hours PP
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Old 02-19-2014, 15:41   #6
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This is well beyond my level of knowledge but it still seems interesting!

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Old 02-19-2014, 15:54   #7
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Originally Posted by gotsomeold View Post
Salim, if this theory is trending in the right direction, it explains why some of my D friends can eat carbs and have low stable BG as long as they fast regularly ... and it underscores why LCHF is so frequently amazingly successful in lowering and regulating even BG that has been out of control for years and years.
Indeed! Some of the studies I cited back then mentioned that the damaged intracellular clean-up process did recover somewhat during extended periods of no incoming nutrients.

However, I still think the best approach is to not have so much in need of disposal in the first place. From what I've read, they are far from equal. Glucose produces many toxins but not ketones.

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Old 02-20-2014, 01:45   #8
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This is well beyond my level of knowledge but it still seems interesting!
ICDogg, Wally and Salim and I are interweaving a whole lot of sometimes-not-clearly related puzzle pieces. Think of us as trying to solve a puzzle where the pieces are in motion ... where, constantly but randomly, new pieces appear and placed pieces vanish ... where there are only blurred hints about what the puzzle is supposed to look like, and from time to time the blurred image changes......

..... Pretty much like trying to understand real life or the mind of a five-year-old when you think about it.

Wally, double thank you for posting that article. I have thought about it a lot today.

Salim, I really like what I think you said: "Avoid the danger. Don't worry about the complexity and the moving puzzle pieces. Eat LCHF. Don't fear the fat."

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DXd myself with PP BG over 270
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8/26/14 HbA1c 5.5
avg BG: 90 - 95 before meals, 100 - 110 one hour PP, 95 2 hours PP
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Old 02-20-2014, 07:33   #9
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Quote:
Originally Posted by gotsomeold View Post
ICDogg, Wally and Salim and I are interweaving a whole lot of sometimes-not-clearly related puzzle pieces. Think of us as trying to solve a puzzle where the pieces are in motion ... where, constantly but randomly, new pieces appear and placed pieces vanish ... where there are only blurred hints about what the puzzle is supposed to look like, and from time to time the blurred image changes......

..... Pretty much like trying to understand real life or the mind of a five-year-old when you think about it.

Wally, double thank you for posting that article. I have thought about it a lot today.

Salim, I really like what I think you said: "Avoid the danger. Don't worry about the complexity and the moving puzzle pieces. Eat LCHF. Don't fear the fat."
Great visual!

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DX: 9/2009 A1C=10.7
A1C 2/2010: 6.7 (DX + 4 months)
A1C 5/2010: 6.0 (DX + 8 months)
A1C 8/2010: 5.7 (DX + 11 months)
A1C 11/2010: 5.1 (DX + 14 months)
A1C 9/2011: 5.6 (DX + 2 years)
A1C 7/2012: 5.5 (DX + 2 years 10 months)
A1C 1/2019: 5.5
Diet: Approximately C:10;P:15;F:75 (as % calories)
Exercise: Not much. Stairs at home & work.
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