Loss of Y chromosome can explain higher cancer risk and shorter life for men

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Loss of Y chromosome can explain higher cancer risk and shorter life for men


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Old 04-29-2014, 12:34   #1
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Default Loss of Y chromosome can explain higher cancer risk and shorter life for men

Loss of Y chromosome can explain higher cancer risk and shorter life expectancy for men - Uppsala University, Sweden

It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Men have a shorter average life span than women and both the incidence and mortality in cancer is higher in men than in women. However, the mechanisms and possible risk factors behind this sex-disparity are largely unknown. Alterations in DNA of normal cells accumulate throughout our lives and have been linked to diseases such as cancer and diabetes.

In a study recently published in the journal Nature Genetics an international team of researchers have analysed the DNA in blood samples from a group of more than 1,600 elderly men.

They found that the most common genetic alteration was a loss of the Y chromosome in a proportion of the white blood cells. The group of men was studied for many years and the researchers could detect a correlation between the loss of the Y chromosome and shorter survival.

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