Metformin , Glipiside .... what else ?

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Metformin , Glipiside .... what else ?


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Old 04-09-2014, 14:48   #1
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Question Metformin , Glipiside .... what else ?

Hi all,

I was on Metformin 2 x 500mg but that doesn't do much for me lately , increasing the dosage bring me great head ache .

Then doc prescribed Glipiside 5mg and I was doing very well , low BG , lots of energy .... BUT made me gain weight and I was constipated all the time .

So I went back to Metformin but my BG is sky high , head ache , tired etc..

I read - Diabetes Drugs - Quick Summary but if I see the side effects I'm getting scared


So, what is the next ? What should I ask the doc to prescribe me ? Should I go with insulin ? Last time he told me is too early to go on insulin . Any idea here ?

Thanks

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41 , 6'5 , ------------------------ Weight
------------------------------ 28-8-12 261 lbs

Metformin 2x500 ------------ 25-10-12 251 lbs

Levothyroxine 2x125---------- 28-1-13 239 lbs

Clonidine 3x0.1 ----------------26-4-13 248 lbs

Amlodipine 10 ---------------- 12-17-13 246 lbs

Amiloride 2x5

Last edited by Hooligan; 04-09-2014 at 14:53.
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Old 04-09-2014, 14:59   #2
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If you are eating LCHF - keeping your carbs way down, taking metformin (or not), and your BG is not staying below the safe limit, then it IS time for insulin.

Has your doctor tested for antibodies to make sure you are T2 and not really T1/LADA? If you are LADA, all the meds in the world will not "treat" your diabetes. You will need insulin. He should also test for your level of insulin production (c-peptide) because this will be more definitive than his just assuming you don't need insulin, even if you are T2.

My personal opinion is that if diet doesn't control BG, (with or without metformin), then insulin is the best choice.

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Old 04-09-2014, 15:06   #3
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Glipiside did great job you know , in the morning my BG was always around 105 , now is 138

He tested me for all kind of things but not sure what , and again with Glipiside I was feeling very well ...

Forgot to mention that for about 2 months now I drink every morning Almased® | Weight Loss for People with Diabetes and it was always around 125 two hours after I taking it, now is 168 Almased help me not to eat in the morning and feel great ... and yes, I'm on LCHF for a year now .

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41 , 6'5 , ------------------------ Weight
------------------------------ 28-8-12 261 lbs

Metformin 2x500 ------------ 25-10-12 251 lbs

Levothyroxine 2x125---------- 28-1-13 239 lbs

Clonidine 3x0.1 ----------------26-4-13 248 lbs

Amlodipine 10 ---------------- 12-17-13 246 lbs

Amiloride 2x5
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Old 04-09-2014, 16:06   #4
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If you are controlling better with glipizide 5mg you are probably not type 1, because you need a functioning pancreas to it to work. But it would hurt to get tested if your doctor will order it. If you are achieving numbers in the low 100 with the starting dosage of 5mg your doctor will probably will not prescribe insulin. You will need another doctor or changes in your diet to counteract the effect of the sulfonylurea on weight gain.

Here is a good summary of this type of drugs and their good and bad effects;

Insulin Secretagogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives

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Old 04-09-2014, 16:11   #5
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Thanks but what another doc is going to order ? Glipiside worked well , in the afternoon my numbers been usually in the 90's ... I was feeling great but gained 17 lbs in 4 weeks

Now I'm losing weight but my BG is high .... you know , is the catcha 999

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41 , 6'5 , ------------------------ Weight
------------------------------ 28-8-12 261 lbs

Metformin 2x500 ------------ 25-10-12 251 lbs

Levothyroxine 2x125---------- 28-1-13 239 lbs

Clonidine 3x0.1 ----------------26-4-13 248 lbs

Amlodipine 10 ---------------- 12-17-13 246 lbs

Amiloride 2x5
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Old 04-09-2014, 16:14   #6
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So, it's my understanding that glipizide effectively "squeezes" and stresses the pancreas in order to get it to produce insulin?

So is it possible that the pancreas is worn out and a solution to consider might be moving to insulin/metformin combination?

I see very low doses of Metformin were prescribed, so perhaps the problem was not enough of it.

Just my opinion on the situation. And of course, you don't mention what you typically eat, so you might be eating too many carbs for the drugs to counteract?

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Old 04-09-2014, 17:03   #7
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Quote:
Originally Posted by jademuffin View Post
So, it's my understanding that glipizide effectively "squeezes" and stresses the pancreas in order to get it to produce insulin?

So is it possible that the pancreas is worn out and a solution to consider might be moving to insulin/metformin combination?

I see very low doses of Metformin were prescribed, so perhaps the problem was not enough of it.

Just my opinion on the situation. And of course, you don't mention what you typically eat, so you might be eating too many carbs for the drugs to counteract?
As I stated earlier , in the begin we tried 3 a 4 x 500mg Metformin , it makes me dizzy and head ache , so more then 2x500ng I can't take.

What I eat - last 2 months - in the morning a shake Almased , salad with some protein for lunch , salad or just vegies and some meat for dinner . Barely eat any bad carbs .

That combination Metformin + Insulin sounds great ... if the insulin doesn't make me gain weight

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41 , 6'5 , ------------------------ Weight
------------------------------ 28-8-12 261 lbs

Metformin 2x500 ------------ 25-10-12 251 lbs

Levothyroxine 2x125---------- 28-1-13 239 lbs

Clonidine 3x0.1 ----------------26-4-13 248 lbs

Amlodipine 10 ---------------- 12-17-13 246 lbs

Amiloride 2x5
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Old 04-09-2014, 18:11   #8
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In my opinion, the Almased shake is half the problem, especially if you are like many of us who are more carb sensitive in the mornings. That stuff has 15g of carbs in one single serving (8 tbsp); the three main ingredients are soy protein isolate, honey and skim milk yogurt powder.

Just because they say it's diabetes friendly, doesn't make it true, and it sure doesn't fit well with the LCHF way-of-eating. If I were you, I'd go with the JERF plan - 'just eat real food' - and stick with bacon & eggs for breakfast.




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Old 04-09-2014, 19:17   #9
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Quote:
Originally Posted by Shanny View Post
In my opinion, the Almased shake is half the problem, especially if you are like many of us who are more carb sensitive in the mornings. That stuff has 15g of carbs in one single serving (8 tbsp); the three main ingredients are soy protein isolate, honey and skim milk yogurt powder.

Just because they say it's diabetes friendly, doesn't make it true, and it sure doesn't fit well with the LCHF way-of-eating. If I were you, I'd go with the JERF plan - 'just eat real food' - and stick with bacon & eggs for breakfast.
Thanks Shanny ,

When I toke Glipiside my sugar after taking the shake was in 120's , now in 160's

I'm taking that shake so I don't have to eat breakfast ... eating twice a day I think is enough , however , if I don't take that shake, how can I get trough the morning hours ? Just butter with coffee/tea ?

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41 , 6'5 , ------------------------ Weight
------------------------------ 28-8-12 261 lbs

Metformin 2x500 ------------ 25-10-12 251 lbs

Levothyroxine 2x125---------- 28-1-13 239 lbs

Clonidine 3x0.1 ----------------26-4-13 248 lbs

Amlodipine 10 ---------------- 12-17-13 246 lbs

Amiloride 2x5
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Old 04-09-2014, 19:52   #10
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Hooligan? How did you come to the decision that eating twice a day is enough? You might not be chewing, but you are definitely EATING when you have the shake in the morning, and what you are eating/drinking is CARBS. Skipping meals is not a good way to manage blood sugar OR to lose weight, either one.

If you are determined to have a liquid 'breakfast', then yes - make bullet proof coffee or tea by adding butter, HWC, and coconut oil. Several of our members use it as their breakfast and it seems to carry them through until lunch.




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