Fiasp Insulin - Page 2

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Fiasp Insulin - Page 2


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Old 07-05-2017, 00:20   #11
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Quote:
Originally Posted by MtlKnight View Post
That article looks flaky to me, nasal insulin isn't going to cure Type 1 diabetes for starters, he seems like a bit of an odd individual.

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Sorry to go off topic. So far Fiasp seems like a good upgrade in terms of lowering sugars faster. It's already resulted in me not wanting to stack shots to bring it down faster. Apparently it also requires only 80% of the dose of humalog to get the same effect.
Not my experience, more like 200%, although I only use it to bring down hypers.

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My current goal is to lower insulin to 40 units a day without fail. Then 30, then 20, then 10. On fasting days I can certainly get by close to 15 units of fast acting already.
Why would you fast? They always tell me never to do that because of ketoacidosis. Also dangerous if you have high BP.

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In a few months if my endo is happy with the results he'll put me on Toujeo instead of Lantus and also let me try Invokana (they prescribe it to type 1s in a study). I'm fine with monitoring my ketones so not worried about DKA. And since I'm a guy I'm not too worried about UTIs (though I know it can happen to us too, it's just much less likely).

One thing I learned during my visit yesterday was about metformin, apparently it boosts your endogenous GLP-1 production by 25% (boosting beta cell replication and function). That I was not aware of, I thought it just reduced insulin resistance directly. Another cool thing is that it's an ancient root that the greeks used to give their diabeticos patients. Or something along those lines. I asked him to get on metformin but he said no. (for now). This endo is really the most knowledgable doc I've ever met about the various experimental drugs and is quite on top of these things. I got about a four month supply of Fiasp samples for free. Bonus!
Apparently in Montréal you get to see your endocrinologist on a regular basis, lucky you. Interesting about the drugs for Type 2 diabetics, never once has an endocrinologist even raised the subject with me.

My GP had never heard of Fiasp and he referred me to an endocrinologist, six month wait.

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Old 07-05-2017, 00:55   #12
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Recently, I have been seeing some research (in the news) regarding the possibility of prescribing Metformin for Type 1 diabetics.

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Metformin does not improve glycemic control in patients with long-term type 1 diabetes (T1D), but the treatment does have a role in managing cardiovascular (CV) risk in these patients, according to data from a recent international trial published in Lancet Diabetes and Endocrinology. CVD Risk Management in Type 1 Diabetes Improved With Metformin

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Old 07-05-2017, 02:18   #13
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That article looks flaky to me, nasal insulin isn't going to cure Type 1 diabetes for starters, he seems like a bit of an odd individual.
Definitely a sketchy source, but that guy was doing it for kicks and the brain boosting power, so I read up on his and other experience doing it to make sure it wouldn't kill me if I tried it. I did and it didn't. The reason I went there is because of that other science link isn't the first time I've read about nasal insulin being used for type 1 diabetes. There's another study about reversing the autoimmune response to the insulin molecule, where participants inhale a precursor of insulin, pro-insulin, to "tolerize" the immune system to the insulin molecule, similar to eating tiny traces of nuts to get over an allergy or to become immune to various poisons. I spoke to the researcher about it directly and he said it might work with normal synthetic insulin too.

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Not my experience, more like 200%, although I only use it to bring down hypers.
Yeah, I wanted to really test this new insulin by giving it a challenging task: I ordered a steak sub for dinner. And boy was my sugar high. I had to take like 2 shots of 30 units. Ouch. I might be in line for a hypo later but I guess I was expecting too much out this insulin. I'll have to adjust my dose, and my expectations, accordingly.


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Originally Posted by Steve_ View Post
Why would you fast? They always tell me never to do that because of ketoacidosis. Also dangerous if you have high BP.
It's not really fasting, it's pseudo fasting. From Dr Longo. Idea is you eat 500-700 calories a day for seven days, with very low protein and higher complex carbs and fat, which your body takes as being effectively in starvation mode. When it does that your glycogen stores deplete and your weakest cells go into pre-programmed cell death, while your muscles and healthy cells are undamaged. This applies to your immune system too, (they use this for cancer patients, so it's legit). Then when you re-feed your IGF-1 goes back up to normal and when that happens, your internal organs (including beta cells) start rebuilding themselves. Something to do with triggering stem cells replicating or differentiating again.

In terms of DKA it's no different than monitoring your ketones on a ketogenic diet, and my levels were fine. (midrange values on ketostix)

Quote:
Originally Posted by Steve_ View Post
Apparently in Montréal you get to see your endocrinologist on a regular basis, lucky you. Interesting about the drugs for Type 2 diabetics, never once has an endocrinologist even raised the subject with me.

My GP had never heard of Fiasp and he referred me to an endocrinologist, six month wait.
I had a real hard time over the years finding an endo, especially one that I liked who was up to date on the latest research and drugs, especially cross-over drugs like Victoza (GLP-1) which have been studied for the past five years or so to help type 1s. I originally got on Victoza by going to a walk-in clinic and telling them I had type 2 diabetes and my main doc was on vacation and I needed a refill. Best move I ever did, that drug is the single best drug I've ever taken, cut my sugar variance in half overnight. As well as my dose. Post-meal excursions were really slow, allowing my short-acting insulin time to work. This year I started on Trulicity which is a 1/week version. Works pretty good although I don't have private insurance any more so I can't afford it. Bummer.

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