diabetes & alzheimers

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diabetes & alzheimers


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Old 09-29-2012, 17:15   #1
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At dinner last night, a friend told me about this viewpoint article in the Guardian, where George Monbiot summarizes what he learned by reviewing some of the science linking alzheimers' disease to metabolic dysfuntion (some scientists are calling it "type iii diabetes." The article includes original references he read. Don't know how sound this notion is, as I've not read any of the literature.

George Monbiot – The Mind Thieves

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Old 09-29-2012, 18:26   #2
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There seems a chance that it could be related. Hence, my decision to keep my BG under control as well as the other consequences of running a high blood glucose! Thanks for the article.




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Old 10-11-2012, 10:44   #3
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Quote:
Originally Posted by 4thcorner View Post
At dinner last night, a friend told me about this viewpoint article in the Guardian, where George Monbiot summarizes what he learned by reviewing some of the science linking alzheimers' disease to metabolic dysfuntion (some scientists are calling it "type iii diabetes." The article includes original references he read. Don't know how sound this notion is, as I've not read any of the literature.

George Monbiot – The Mind Thieves
There is more and more about this in the literature. This is what appears to me to be the case after a lot of reading.

1) There is no direct causation between diabetes and Alzhemier's. Rather, they have some of their respective causes in common.

2) High blood sugar is a symptom of T2 diabetes and not the disorder itself.

3) Nerves in the brain develop their own "insulin resistance" 10 to 30 years before any apparent symptoms of Alzheimer's. Cells in the body can use three things for life support (energy): glucose, free fatty acids and ketones. The first two are generally available in any non-starving human. Ketones are only available on either greatly reduced carb/protein intake (dietary sources of glucose) or during extended periods of not eating anything. This is not diabetes nor the IR of diabetes but something entirely separate.

4) When glucose from diet becomes both excessive and too frequent, it blocks the other two sources of cellular energy. FFAs mostly and ketones completely because they never even get produced. Even on a "normal" (I call it "high-carb") diet, many people will produce ketones in the last part of the night when they haven't eaten for many hours.

If one is genetically predisposed to diabetes, this constant and over-abundant flow of glucose from diet will cause its onset. Over the last 30 years, as the role of fat in diet has decreased and that of carbs and proteins has increased, diabetes has tripled.

If the nerves in your brain have developed their own "insulin resistance" (the precursor to Alzheimer's and dementia), this same diet will completely block the possibility of ketones and so the brain will never get an alternative fuel. The nerve cells will slowly starve and dementia/Alzheimer's will be the result. FFAs are blocked by the blood-brain barrier and so ketones are the only viable alternative.

Dr. Veech at NIH is working on a ketone "pill" which I personally think is a misguided approach since one can have ketones available 24/7 simply by eating a more natural diet (I do). Then again, there's not much money to be made telling people that!

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Old 10-11-2012, 18:09   #4
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I think this is just one of many possible causes -- my father-in-law had Alzheimer's. We are pretty sure in his case there was a strong genetic component because an uncle of his most likely had it too. The uncle had dementia before Alzheimers' was recognized but by the description of his behaviors in his last years, we are pretty sure he had it too.
However, my FIL was a farmer all his life. And they used a lot of chemicals and did not take measures to protect themselves from the chemicals they used. This most likely contributed. He was of average weight most of his life, thin in his later years. And he never showed any diabetic symptoms.

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