Two new proteins associated with obesity and diabetes

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Two new proteins associated with obesity and diabetes


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Old 01-09-2013, 11:15   #1
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Default Two new proteins associated with obesity and diabetes

Two new proteins associated with obesity and diabetes

“First identified by Hsu, TRIP-Br2 helps regulate how fat is stored in and released from cells. To understand its role, the researchers compared mice that lacked the gene responsible for production of the protein, with normal mice that had the gene.

They quickly discovered that mice missing the TRIP-Br2 gene did not gain weight no matter what they ate - even when placed on a high-fat diet - and were otherwise normal and healthy. On the other hand, the mice that still made TRIP-Br2 gained weight and developed associated problems such as insulin resistance, type 2 diabetes and high cholesterol when placed on a high-fat diet. The normal and fat-resistant mice ate the same amount of food, ruling out differences in food intake as a reason why the mice lacking TRIP-Br2 were leaner.”

(snip)

When functioning normally, TRIP-Br2 restricts the amount of fat that cells burn as energy. But when TRIP-Br2 is absent, a fat-burning fury seems to occur in fat cells. Although other proteins have been linked to the storage and release of fat in cells, TRIP-Br2 is unique in that it regulates how cells burn fat in a few different ways, Hsu said. When TRIP-Br2 is absent, fat cells dramatically increase the release of free fatty acids and also burn fat to produce the molecular fuel called ATP that powers mitochondria -the cell's energy source. In addition, cells free from the influence of TRIP-Br2 start using free fatty acids to generate thermal energy, which protects the body from exposure to cold.

Discovery Of Protein That Could Be Key To Fighting And Preventing Obesity

Here is another one:

"Without p62 you're making lots of fat but not burning energy, and the body thinks it needs to store energy," said Jorge Moscat, Ph.D., Sanford-Burnham professor. "It's a double whammy." Moscat led the study with collaborators at Helmholtz Zentrum München in Germany and the University of Cincinnati.

p62 and obesity

Moscat's team had previously produced mice that completely lack the p62 protein everywhere in their bodies. As a result, the animals were obese. They also had metabolic syndrome. In other words, as compared to mice with p62, mice lacking p62 weighed more, expended less energy, had diabetes and had a hyper-inflammatory response that's characteristic of obesity.

Protein P62 Balances Metabolism In Fat Tissue - Making It An Attractive Target For Anti-Obesity Therapies

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Old 01-09-2013, 11:32   #2
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An example of differences.

I come from a family of two brothers one sister, we all ate like horses all the time, immense amounts of food. The oldest was 6 foot tall 250 lbs, me I was 6 foot 1 inch 250 lbs. the middle child which ate more than all of us was 6 foot 4 inches and maybe soaking wet 170 lbs, he had a 29 inch waist. I seen him eat for lunch a pack of hot dogs with buns and a half gallon of ice cream. Our mother was the same, she could eat pretty much what she wanted and remained thin most of her life.

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