Old drug may point the way to new treatments for diabetes and obesity

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Old drug may point the way to new treatments for diabetes and obesity


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Old 02-11-2013, 14:50   #1
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Default Old drug may point the way to new treatments for diabetes and obesity

University of Michigan News Service | Old drug may point the way to new treatments for diabetes and obesity

ANN ARBOR—Researchers at the University of Michigan's Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment of asthma and other uses, also reverses obesity, diabetes and fatty liver in mice.

(snip)

"Amlexanox appears to work in mice by inhibiting two genes—IKKE and TBK1—that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less, energy."

(snip)

"These studies tell us that, at least in mice, the IKKE/TBK1 pathway plays an important role in defending body weight by increasing storage and decreasing burning of calories, and that by inhibiting that pathway with a compound, we can increase metabolism and induce weight loss, reverse diabetes and reduce fatty liver," Saltiel said.

The drug has been on the market in Japan for more than 25 years.

However, the researchers don't yet know if humans respond with the same pathway, or if the discovery of amlexanox's effectiveness in mice can lead to a compound that is safe and effective for treating obesity and diabetes in humans.

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Old 02-11-2013, 16:05   #2
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I don't know, it doesn't seem wise to me to bag drive our metabolism in an attempt to lose weight. The study in mice also doesn't allow us to know if there are any mental side effects from pushing our metabolism that hard. Not to mention that mice only live two years anyway, so what would the effect on the human heart be from raising the metabolism over years? And when the mice stopped the drug, they regained the weight, so this would be a lifetime drug.

I won't be signing up for the trials, that's for sure.

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Old 02-11-2013, 16:13   #3
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I don't know, it doesn't seem wise to me to bag drive our metabolism in an attempt to lose weight. The study in mice also doesn't allow us to know if there are any mental side effects from pushing our metabolism that hard. Not to mention that mice only live two years anyway, so what would the effect on the human heart be from raising the metabolism over years? And when the mice stopped the drug, they regained the weight, so this would be a lifetime drug.

I won't be signing up for the trials, that's for sure.
Good points!


It seems to me that this is the wrong approach. Too bad there's no money to be made in promoting what really works - reducing the need for insulin by eating low carb. But that's the way with research - the search for a marketable pill.

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Old 02-11-2013, 17:43   #4
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Obviously you have not had great difficulty in your attempt to lose weight. I have been lc/hf woeing now for over a year, I've restarted using insulin during that time, and am currently using an insulin pump. I am a Type 2, and obviously I'm very insulin resistant, have every check off for metabolic syndrome with the exception of high blood pressure, and still haven't lost any weight. I don't know that I would want to take a drug for the rest of my life, but isn't that what I am doing with insulin (realistically)? If I am unable to lose weight, reduce the need for insulin because without weight loss the IR doesn't improve, then I'm a lifer on insulin. I know insulin is for the most part safe...don't know about this new drug, but if they were able to be sure it did not have severe side effects, I'd probably try it. People are getting bariatric surgery to lose weight so they can "reverse" their diabetes; but if you continue to eat wrong, then you will eat your way right back to obesity and the same difficulties you began with. So basically by having the surgery, you are altering yourself for the remainder of your life. You will never be able to go back to eating the way you did before surgery. Also, bariatric surgery has its own negative side effects.

I think unless you've really been a person to struggle with the Catch-22's of diabetes, you really don't know what a person would do in desperation.

That's just my opinion. Yours may differ, and I appreciate that.

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Old 02-11-2013, 19:11   #5
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Just a gut reaction to the description of this thing: I'd fear the major side effect would be shorter lifespan!

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Old 02-11-2013, 20:55   #6
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Is no longer has a patent so it will be hard for any pharmaceutical company to invest to get approval of this drug for this use, unless they can find a way to produce a similar compound that could be patent. They will probably investigate the path way to see if it work on humans and see they can produce something similar that work on them. But don’t expect to see any development on this anytime soon.

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Old 02-11-2013, 21:47   #7
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Renee, I know what you mean. I criticize the drug, but once it's past trials and available, if it ever is, I would be sorely tempted to take it even if it shortened my life. I have been overweight since I was 8 years old. To spend even five years at a "normal" weight seems like a dream.

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Old 02-11-2013, 22:50   #8
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I have been struggling with my weight for too long. My thyroid is fine and the only explanation I can get from a doctor for why I'm cold, tired and overweight is that it's a personal failing. It sure does seem to me though that my metabolism is much "slower/lower" than it should be. If someone offered me a drug that would help combat that... heck yes I would try it. It's not about vanity it's about quality of life...

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Old 02-12-2013, 03:37   #9
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Quote:
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Just a gut reaction to the description of this thing: I'd fear the major side effect would be shorter lifespan!
But if I am unable to obtain tight control of my blood sugars even with intervention such as I am doing (insulin pump, lc/hf woe, exercise), and I am unable to lose weight doing all of the things listed, am I not shortening my lifespan anyway, or in jeopardy of developing complications from the diabetes? One way or another, this argument can be debated for the pros and cons by many. If you have never suffered being overweight, obese, or grossly obese, then you don't know what it is like to try every diet out there, exercise to the point of exhaustion, starving yourself in an attempt to lower the caloric intake, etc., then you have no idea of the struggles obese people face. I have been overweight since childhood pretty much. I managed a few times to get within range or what is deemed "normal" weight for my height and gender, but that was when I was much younger (as in a teenager) and could exist on one meal a day. I am very careful with what I eat now, and I get my exercise as much as possible, and take my supplements and meds. Again, if you cannot relate to not being able to bring your foot up to your knee so you can tie your shoes, or bend over without feeling like you are going to pass out because your big old belly is getting in the way of breathing, or you pay more for clothing because you are "plus" sized, then you really cannot fathom the desperation you begin to feel to lose weight. Also, you deal with the ridicule and name calling all your life. People look at you sometimes and think "what a pig. She must eat a ton of food." Did you ever see the movie "Shallow Hal"? That movie to me is despicable. Now mind you, I'm not like "tons of fun" obese, but I'm still probably at least 100+ lbs overweight of what the standard charts say I should be. Do I want to be this big? Of course not! But again, this can be debated forever. If you lived your life in my shoes for as long as I have (50 yrs), you would seriously consider taking a drug that could prove to help you shed those pounds. I worry about suffering complications every day because I am a Type 2 diabetic. I do everything in my power to help diminish those odds, but if what I am doing does not help me to lose weight to help control my diabetes, then I'm doomed anyway to an early grave.

Sorry this sounds like a rant. It really isn't. I just am a very passionate writer when it comes to topics I know too much about because I live it every single day.

Thanks for reading if you've gotten this far. I just want people without a weight issue out there to understand sometimes you can do everything right and you still struggle.

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Old 02-12-2013, 03:41   #10
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Renee, I know what you mean. I criticize the drug, but once it's past trials and available, if it ever is, I would be sorely tempted to take it even if it shortened my life. I have been overweight since I was 8 years old. To spend even five years at a "normal" weight seems like a dream.
I can certainly relate to this silvertiger. I'd love to just once wear a provocative dress and look really sexy in it. It is hard to look at myself sideways in the mirror because it just looks like the beginning to the old Alfred Hitchcock mystery show.

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