Up to Half of Gestational Diabetes Patients Will Develop Type 2 Diabetes, Study Finds

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Up to Half of Gestational Diabetes Patients Will Develop Type 2 Diabetes, Study Finds


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Old 03-08-2013, 11:01   #1
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Default Up to Half of Gestational Diabetes Patients Will Develop Type 2 Diabetes, Study Finds

Up to Half of Gestational Diabetes Patients Will Develop Type 2 Diabetes

Genetic insulin secretion defect linked to rapid onset of type 2 diabetes after birth

Newswise — Chevy Chase, MD ––Women who were diagnosed with gestational diabetes during pregnancy face a significantly higher risk of developing Type 2 diabetes in the future, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

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Researchers identified two distinct groups of women who were at risk – those who developed Type 2 diabetes within two months of giving birth and those who took a year or more to progress to a Type 2 diabetes diagnosis. Although obesity was a major risk factor for both groups, researchers found genetic variations that could explain the timing of the disease’s onset.

Women who rapidly developed Type 2 diabetes had a significant defect in insulin secretion. Among this population, researchers found a variation in the HHEX (hematopoietically expressed homeobox) gene that is associated with Type 2 diabetes.

Women who were slower to develop Type 2 diabetes were more likely to have a variation in the CDKAL1 gene, which also has been linked to Type 2 diabetes.

More research into genetic and environmental risk factors is needed to develop models that can better predict who will develop Type 2 diabetes, Kwak said. In the meantime, women who had gestational diabetes should undergo regular blood sugar testing.

“It is crucial for women who had gestational diabetes to have their blood sugar levels checked two months after giving birth and annually thereafter,” Kwak said. “In addition to the problems undiagnosed Type 2 diabetes poses to the mother, leaving the disease untreated increases the risk of any future children developing congenital disorders.”

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Old 03-08-2013, 12:14   #2
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Only half? That's probably only double the rate for the general population. I always thought it was more than that.

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Old 03-08-2013, 14:09   #3
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So, if having GD is an indication of poor pancreatic functioning under the stress of pregnancy - (duh!) - then it would be prudent for those mothers to stay on a reduced carbohydrate diet from that point on. But that is not what they are advised to do. More's the pity.

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Old 03-08-2013, 14:54   #4
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Too bad they did not ALSO test for GAD-65 autoantibodies in those GD women ... because I know one HELL of a lot of misdiagnosed LADAs, who started out with GD!

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Old 03-08-2013, 15:07   #5
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Quote:
Originally Posted by foxl View Post
Too bad they did not ALSO test for GAD-65 autoantibodies in those GD women ... because I know one HELL of a lot of misdiagnosed LADAs, who started out with GD!
Good point!

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