Dulaglutide, Diabetes Drug, As Good As Insulin In Study

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Dulaglutide, Diabetes Drug, As Good As Insulin In Study


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Old 04-20-2013, 02:52   #1
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Default Dulaglutide, Diabetes Drug, As Good As Insulin In Study

Dulaglutide, Diabetes Drug, As Good As Insulin In Study

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Old 04-20-2013, 02:58   #2
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Fascinating!

Before I'd consider a switch, I would like to know more about potential side-effects, of course.

But once a week would be sooooo coooool ...

Thanks for sharing!

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Old 04-20-2013, 13:17   #3
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We will have to see if it has the same problems that others incretin drugs have been recently been associated with pancreatitis, pancreatic and thyroid cancer.

FDA Drug Safety Communication: FDA investigating reports of possible increased risk of pancreatitis and pre-cancerous findings of the pancreas from incretin mimetic drugs for type 2 diabetes

Diabetes - incretin mimetic drugs for type 2 diabetes - Dangerous Prescription Drugs

[3-14-2013] The U.S. Food and Drug Administration (FDA) is evaluating unpublished new findings by a group of academic researchers that suggest an increased risk of pancreatitis, or inflammation of the pancreas, and pre-cancerous cellular changes called pancreatic duct metaplasia in patients with type 2 diabetes treated with a class of drugs called incretin mimetics. These findings were based on examination of a small number of pancreatic tissue specimens taken from patients after they died from unspecified causes. FDA has asked the researchers to provide the methodology used to collect and study these specimens and to provide the tissue samples so the Agency can further investigate potential pancreatic toxicity associated with the incretin mimetics.

http://www.medscape.com/viewarticle/770974_4

Comparing GLP-1RAs and DPP-4Is: Efficacy, Tolerability and Safety

GLP-1RAs and DPP-4Is modulate the incretin system using different modes of action: GLP-1RAs via pharmacological doses of exogenous GLP-1 mimetics and DPP-4Is by enhancing physiological levels of endogenous GLP-1. As a result, GLP-1RAs have a more potent efficacy profile than DPP-4Is, but are associated with increased GI side effects.

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