Roundworm quells obesity and related metabolic disorders

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Start Here > Diabetes News

Diabetes News The Diabetes News section is a place to share any new stories or information you have come across related to Diabetes for the rest of the forum to share and discuss. If you have seen or read about new medication, diabetes treatments, medical breakthroughs or any interesting stories of personal interest then please post and discuss them here. From time to time we will take some of the Diabetes News stories from this section and write them up in our Diabetes Blog.


Like Tree1Likes
  • 1 Post By silvertiger

Roundworm quells obesity and related metabolic disorders


Closed Thread
 
Shared Thread Thread Tools
Old 04-26-2013, 12:39   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Roundworm quells obesity and related metabolic disorders

(What are they are going to come up with now!!!)

Roundworm quells obesity and related metabolic disorders

Researchers at the University of Maryland School of Medicine, Baltimore, have shown in a mouse model that infection with nematodes (also known as roundworms) can not only combat obesity but ameliorate related metabolic disorders. Their research is published ahead of print online in the journal Infection and Immunity.

Gastrointestinal nematodes infect approximately 2 billion people worldwide, and some researchers believe up until the 20th century almost everyone had worms. In developed countries there is a decreasing incidence of nematode infection but a rising prevalence of certain types of autoimmunity, suggesting a relationship between the two. Nematode infection has been purported to have therapeutic effects and currently clinical trials are underway to examine worms as a treatment for diseases associated with the relevant cytokines, including inflammatory bowel disease, multiple sclerosis, and allergies.

In the study researchers tested the effect of nematode infection on mice fed a high-fat diet. Infected mice of normal girth gained 15 percent less weight than those that were not infected. Mice that were already obese when infected lost roughly 13 percent of their body weight within 10 days. Infection also drastically lowered fasting blood glucose, a risk factor for diabetes, and reduced fatty liver disease, decreasing liver fat by ~25 percent, and the weight of the liver by 30 percent.

The levels of insulin and leptin also dropped, "indicating that the mice restored their sensitivities to both hormones," says corresponding author Aiping Zhao of the University of Maryland School of Medicine, Baltimore. Leptin moderates appetite. As with too much insulin, too high a level of leptin results in insensitivity, thus contributing to obesity and metabolic syndrome, Zhao explains.

The mechanism of the moderation of these hormones "was associated with a parasite-induced reduction in glucose absorption in the intestine, reduced liver triglycerides, and an increase in the population of cells called "alternatively activated macrophages," which regulate glucose metabolism and inflammation," says coauthor Joe Urban of the United States Department of Agriculture. Some of these changes involved "a protein called interleukin-13 and related intracellular signaling mechanisms," he says. "This suggests that there are immune related shifts in metabolism that can alter expression of obesity and related metabolic syndrome."

The incidence of obesity has been climbing dramatically, worldwide. It is a key risk factor for many metabolic diseases, including diabetes, hypertension, and heart disease. Recent studies indicate that it is accompanied by chronic low-grade inflammation in adipose tissues, causing the release of proinflammatory cytokines and chemokines that contribute to the development of cardiovascular disease and metabolic syndrome.

Parasitic nematode infection induces a marked elevation in host immune Th2-cells and related type 2 cytokines which, besides combating the infection, also have potent anti-inflammatory activity, according to the report.

kantim is offline  
Old 04-26-2013, 14:58   #2
Senior Member
 
Join Date: Dec 2009
Location: Kansas City, MO USA
Posts: 5,911

Member Type
Type 1
Diagnosed in 2009 as Type 1.5

5212 likes received
9205 likes given
Default

UUUUUUUUUUUUGH. Just treated my street cat (who has mostly moved indoors, now) for worms ... he is obese, but frankly I think it is from eating the neighbors' kibble! I worry about his blood sugar ... a LOT. Not enough to reinfect him, though ... (as far as I know he only had tapeworms, but used a broad-spectrum wormer!).

foxl is offline  
Old 04-26-2013, 16:33   #3
Senior Member
 
silvertiger's Avatar
 
Join Date: Nov 2011
Location: Saskatchewan, Canada
Posts: 3,861

Member Type
Type Pre
Diagnosed in 2011

4282 likes received
5061 likes given
Default

Well they used to sell tapeworms in old magazines for weight loss, so this doesn't surprise me. What does surprise me is that they'd ignore the other problems with having a worm infestation, and not mention that by the way, we don't know what the long term consequences of having worms is, other than perhaps forced celibacy if your partner finds out. Ewwwww.

Patdart likes this.
__________________

View silvertiger's full Diabetes Forum profile here.
silvertiger is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Binge Eating May Represent A Sub-Type Of Obesity Most Closely Related Drug Addiction kantim Diabetes Diet and Nutrition 0 04-25-2013 12:10
Grape intake may protect against metabolic syndrome-related organ damage kantim Diabetes Diet and Nutrition 8 04-24-2013 06:04
Birth Order Linked to Increased Risk of Diabetes, Metabolic Disorders kantim Diabetes News 2 02-14-2013 00:23
Eating disorders over 50 foxl Diabetes Forum Lounge 1 06-22-2012 04:45
Yet another question RE Corelated disorders kas77 Diabetes Forum Lounge 5 04-29-2010 04:52

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 11:05.




Powered by vBulletin®
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.