Injectable Nano-Network Controls Blood Sugar in Diabetics for Days at a Time

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Start Here > Diabetes News

Diabetes News The Diabetes News section is a place to share any new stories or information you have come across related to Diabetes for the rest of the forum to share and discuss. If you have seen or read about new medication, diabetes treatments, medical breakthroughs or any interesting stories of personal interest then please post and discuss them here. From time to time we will take some of the Diabetes News stories from this section and write them up in our Diabetes Blog.


Like Tree5Likes
  • 3 Post By kantim
  • 1 Post By Daytona
  • 1 Post By foxl

Injectable Nano-Network Controls Blood Sugar in Diabetics for Days at a Time


Closed Thread
 
Shared Thread Thread Tools
Old 05-04-2013, 10:42   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Injectable Nano-Network Controls Blood Sugar in Diabetics for Days at a Time

NC State News :: NC State News and Information » Injectable Nano-Network Controls Blood Sugar in Diabetics for Days at a Time

In a promising development for diabetes treatment, researchers have developed a network of nanoscale particles that can be injected into the body and release insulin when blood-sugar levels rise, maintaining normal blood sugar levels for more than a week in animal-based laboratory tests. The work was done by researchers at North Carolina State University, the University of North Carolina at Chapel Hill, the Massachusetts Institute of Technology and Children’s Hospital Boston.

“We’ve created a ‘smart’ system that is injected into the body and responds to changes in blood sugar by releasing insulin, effectively controlling blood-sugar levels,” says Dr. Zhen Gu, lead author of a paper describing the work and an assistant professor in the joint biomedical engineering program at NC State and UNC Chapel Hill. “We’ve tested the technology in mice, and one injection was able to maintain blood sugar levels in the normal range for up to 10 days.”

(snip)

The new, injectable nano-network is composed of a mixture containing nanoparticles with a solid core of insulin, modified dextran and glucose oxidase enzymes. When the enzymes are exposed to high glucose levels they effectively convert glucose into gluconic acid, which breaks down the modified dextran and releases the insulin. The insulin then brings the glucose levels under control. The gluconic acid and dextran are fully biocompatible and dissolve in the body.

Each of these nanoparticle cores is given either a positively charged or negatively charged biocompatible coating. The positively charged coatings are made of chitosan (a material normally found in shrimp shells), while the negatively charged coatings are made of alginate (a material normally found in seaweed).

When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other to form a “nano-network.” Once injected into the subcutaneous layer of the skin, the nano-network holds the nanoparticles together and prevents them from dispersing throughout the body. Both the nano-network and the coatings are porous, allowing blood – and blood sugar – to reach the nanoparticle cores.

“This technology effectively creates a ‘closed-loop’ system that mimics the activity of the pancreas in a healthy person, releasing insulin in response to glucose level changes,” Gu says. “This has the potential to improve the health and quality of life of diabetes patients.”

Daytona, Juanita and rpbaum00 like this.
kantim is offline  
Old 05-04-2013, 16:22   #2
Moderator
 
Daytona's Avatar
 
Join Date: Aug 2011
Location: Chicago, IL
Posts: 2,665

Member Type
Type 2
Diagnosed in 2010

3089 likes received
2882 likes given
Default

Holy cow! That is some seriously cool stuff. It's like something straight out of a science fiction book.

foxl likes this.
__________________
Pumping insulin since 2017
Daytona is offline  
Old 05-04-2013, 17:20   #3
Jen
Senior Member
 
Join Date: Apr 2010
Location: Topanga, CA
Posts: 710

Member Type
Type 1
Diagnosed in 2007

506 likes received
229 likes given
Default

This is the first development in BG control that looks like it could make a real difference. How it's translated from mice to men, though, is still a big question. If that's possible, it's a very exciting line of study.

Jen

Jen is offline  
 
Old 05-04-2013, 17:31   #4
Senior Member
 
Join Date: Dec 2009
Location: Kansas City, MO USA
Posts: 5,911

Member Type
Type 1
Diagnosed in 2009 as Type 1.5

5212 likes received
9205 likes given
Default

Quote:
Originally Posted by Daytona View Post
Holy cow! That is some seriously cool stuff. It's like something straight out of a science fiction book.
Yeah, sci-fi ... currently reading this one http://www.amazon.com/Shift-Omnibus-Edition-Silo-Volume/dp/1481983555/ref=sr_1_1?ie=UTF8&qid=1367685032&sr=8-1&keywords=shift
And the thought of that "drug" creeped me out!!!

Daytona likes this.
foxl is offline  
Old 05-04-2013, 18:00   #5
Senior Member
 
Join Date: Sep 2012
Location: Virginia, USA
Posts: 881

Member Type
Type 2
Diagnosed in 2012

848 likes received
355 likes given
Default

Quote:
Originally Posted by foxl View Post

Yeah, sci-fi ... currently reading this one Video Link: http://www.amazon.com/Shift-Omnibus-Edition-Silo-Volume/dp/1481983555/ref=sr_1_1?ie=UTF8&qid=1367685032&sr=8-1&keywords=shift

And the thought of that "drug" creeped me out!!!
Oh my gosh!!! I am so buying that series!!!!!!! I live sci-fi!!!!!

__________________

View Bree's full Diabetes Forum profile here.
Bree is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Is it time to change blood pressure testing regime for diabetics? Editor Diabetes News 3 12-21-2012 17:50
Accucheck nano David Burke Diabetes Treatment 22 10-10-2012 22:08
Study suggests LC/HF gives diabetics improved blood glucose control synger Diabetes 17 05-19-2012 15:02
Long time diabetics Countrygal Diabetes 5 02-22-2011 10:52
Night time low blood sugar-too low? breezeonby Diabetes Symptoms 8 01-30-2010 01:56

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 13:02.




Powered by vBulletin®
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.