Doubts Over New Class Of Diabetes Drugs As Roche Gives Up On Aleglitazar

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Doubts Over New Class Of Diabetes Drugs As Roche Gives Up On Aleglitazar


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Old 07-12-2013, 11:21   #1
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Default Doubts Over New Class Of Diabetes Drugs As Roche Gives Up On Aleglitazar

(They have seen the writing on the wall the PPAR drugs are in for a lot of trouble. The path way has a lot of unwanted side effect. )

Doubts Over New Class Of Diabetes Drugs As Roche Gives Up On Aleglitazar

The decision by pharmaceutical giant Roche to cancel all clinical trials of its diabetes drug aleglitazar may dent confidence in a new class of treatment targeted at people's genetic susceptibility to diabetes.

Roche has listened to safety concerns raised by an independent clinical board and made the decision to halt all clinical development of the drug, which many hoped would reduce cardiovascular risks in people with diabetes.

(snip)

Knock-on effect for other drugs

This news is not bad just for the new PPAR drug - it could have a knock-on effect for another diabetes drug already in widespread clinical use, rosiglitazone (Avandia).

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Old 07-12-2013, 12:32   #2
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Yep. The Indian government also banned pioglitazone just last week.

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Old 07-12-2013, 13:11   #3
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Quote:
Originally Posted by skb View Post
Yep. The Indian government also banned pioglitazone just last week.
GOOD -- not a fan.

I wonder at what price they intended to market the proposed stuff, above ... UGH.

"Knock-on effect for other drugs

This news is not bad just for the new PPAR drug - it could have a knock-on effect for another diabetes drug already in widespread clinical use, rosiglitazone (Avandia). "

WTH does that mean? It would knock other drugs off the market? Is this a marketing decision, only then?


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Old 07-12-2013, 16:14   #4
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Quote:
Originally Posted by foxl View Post
GOOD -- not a fan.

I wonder at what price they intended to market the proposed stuff, above ... UGH.

"Knock-on effect for other drugs

This news is not bad just for the new PPAR drug - it could have a knock-on effect for another diabetes drug already in widespread clinical use, rosiglitazone (Avandia). "

WTH does that mean? It would knock other drugs off the market? Is this a marketing decision, only then?
It means that a promising if not perfect mode of treatment might not get the research it deserves to see if there is a safer way to exploit it to help people. And personally I think the dangers of this or that particular drug being worth it are up to the individual to decide, not for some board of bureaucrats to force a one size fits all solution on people. That method didn't work too well with the food pyramid. One person's intolerable risk is another person's reasonable risk. And people need to understand the difference between a change in relative risk and absolute. Some drugs may increase you're chances of heart attack by 100%! Relatively speaking though that's going from 1% to 2% chance of heart attack, and when weighed against the person's other risk factors might be an acceptable risk to them. Taking the option away might save some lives, it will also deny an option that could be helpful to others. That's the knock on effect.

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