Genetic link to gestational diabetes identified - may one day help predict

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Genetic link to gestational diabetes identified - may one day help predict


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Old 08-02-2013, 12:46   #1
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Default Genetic link to gestational diabetes identified - may one day help predict

Genetic link to gestational diabetes identified - may one day help predict which women are at higher risk

New Northwestern Medicine® research on the genetics of diabetes could one day help women know their risk for developing gestational diabetes before they become pregnant - and lead to preventive measures to protect the health of offspring.

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The findings were published online July 31 in Diabetes, a journal of the American Diabetes Association.

Gestational diabetes has been associated with type 2 diabetes, because, during pregnancy, resistance to insulin increases, similar to the effect of weight gain during a lifetime in a non-pregnant state.

But researchers found variants in two genes - HKDC1 and BACE2 - that were associated with measures of glucose and insulin levels of pregnant women but not associated with these measures in the rest of the population, including people with type 2 diabetes.

"With additional study and verification of these and other risk genes, we could one day have genetic risk profiles to identify individuals at elevated risk for developing gestational diabetes," said M. Geoffrey Hayes, first author of the study.

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Old 08-02-2013, 14:27   #2
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Beta-secretase 2 - Wikipedia, the free encyclopedia

Function

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.[3] It has been reported that BACE2 is the main protease that mediates the release of the amyloidogenic ectodomain of Pmel17 in melanocytes. [4]

HKDC1 (human)

Overview
HKDC1 Belongs to the hexokinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.1; Kinase, other
Cellular Component: mitochondrion; nucleolus; nucleus
Molecular Function: hexokinase activity; ATP binding
Biological Process: glycolysis
Reference #: Q2TB90 (UniProtKB)
Alt. Names/Synonyms: FLJ22761; FLJ37767; hexokinase domain containing 1; Hexokinase domain-containing protein 1; HKDC1; MGC125688; Putative hexokinase HKDC1
Gene Symbols: HKDC1
Molecular weight: 102,545 Da
Basal Isoelectric point: 6.77 Predict pI for various phosphorylation states

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Old 08-02-2013, 14:29   #3
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Does not indicate which chromosomes the second one is; I will look further when more awake ... it is involved in mitochondrial metabolism ... but not a mito gene.

The first one, awww poop.

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