Low LDL, Statins Increases Mortality in those with Heart Failure

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Low LDL, Statins Increases Mortality in those with Heart Failure


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Old 02-02-2014, 15:50   #1
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Default Low LDL, Statins Increases Mortality in those with Heart Failure

Statins associated with increased risk of death in those with heart failure | Dr Briffa's Blog - A Good Look at Good Health

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... a study recently published in the journal Cardiology that assessed the relationship between LDL-cholesterol levels and health outcomes in a group of 212 elderly individuals with known heart failure [1]. These individuals were split into 3 groups according to their LDL-cholesterol levels.

1. < 90 mg/dl
2. 90-115 mg/dl (2.3-3.0 mmol/l)
3. >115 mg/dl

Over an average of 3.7 years, the individuals in the 1st group (with then lowest LDL levels) fared worst. Those in group 3 (with the highest LDL levels) fared the best. 58 per cent of people in group 3 lived at least 50 months compared to just 34 per cent in group 1.
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Why might low LDL-cholesterol levels be a risk factor for mortality? The authors point out that cholesterol can alter the functioning of certain inflammatory substances (including C-reactive protein and cytokines), and therefore low-cholesterol might lead to a more inflammatory state (which is not healthy).

One very interesting thing about this study was that it found that mortality across the groups was no different in individuals not treated with statins. What this suggests is that statins might be having a direct effect that is harmful to the hearts and health of individuals with heart failure.

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Old 02-02-2014, 16:04   #2
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I'm not sure I understand this:

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One very interesting thing about this study was that it found that mortality across the groups was no different in individuals not treated with statins. What this suggests is that statins might be having a direct effect that is harmful to the hearts and health of individuals with heart failure.
If the correlations held with or without statins, wouldn't that mean the the bad outcomes correlate with CHOLESTEROL (low = worse outcomes) independent of statins? In other words, it is lowering cholesterol itself which is bad for health, not how you do it?

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Old 02-02-2014, 16:31   #3
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Originally Posted by smorgan View Post
I'm not sure I understand this: If the correlations held with or without statins, wouldn't that mean the the bad outcomes correlate with CHOLESTEROL (low = worse outcomes) independent of statins? In other words, it is lowering cholesterol itself which is bad for health, not how you do it?
Only going off this post and not having read the Link yet this is how I understand your quoted section. The mortality rate remained the same regardless of panel numbers as long as a statin was not involved. When statin use was introduced bad juju happened.

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Old 02-02-2014, 22:17   #4
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I'm gonna make a guess that the three groups were selected on cholesterol values alone (irregardless of statin use or not) and they are saying that those taking statins were just as susceptible to the earlier mortality as those not taking statins in their low cholesterol group. I agree with smorgan's question that low cholesterol is less healthy.

Now I gotta go read.

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Old 02-03-2014, 07:48   #5
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I'm gonna make a guess that the three groups were selected on cholesterol values alone (irregardless of statin use or not) and they are saying that those taking statins were just as susceptible to the earlier mortality as those not taking statins in their low cholesterol group. I agree with smorgan's question that low cholesterol is less healthy.

Now I gotta go read.
Translation (if this is the correct understanding of what was said):

It's not just that statins are horrible drugs because of their side effects - the entire rationale for their existence - i.e., that intervention to lower cholesterol will enhance health is utterly FALSE. It's looking more and more like the OPPOSITE of the truth, actually.

Of course another big problem with statins is that they attack a fly with a sledgehammer. In the effort to squelch the production of cholesterol (a stupid idea in the first place, it seems), they sabotage a bodily process way too far up the chain which has many other effects besides the intended one (as if that wasn't bad enough). Hence the need for COQ10, something found in every cell of the body and which healthy people never need to supplement.

As I recall, I believe there are something like a dozen other processes which are negatively affected by this sledgehammer.
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Old 02-04-2014, 08:39   #6
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The health of the brain is one other process that is effected by stations..ie.....hemorrhage.

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Old 02-04-2014, 08:43   #7
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It's difficult to attribute statin-pushing to mere stupidity. I do try, mind you, but I fail.

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