Ottawa researchers find new pathway connected to Type 2 diabetes

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Start Here > Diabetes News

Diabetes News The Diabetes News section is a place to share any new stories or information you have come across related to Diabetes for the rest of the forum to share and discuss. If you have seen or read about new medication, diabetes treatments, medical breakthroughs or any interesting stories of personal interest then please post and discuss them here. From time to time we will take some of the Diabetes News stories from this section and write them up in our Diabetes Blog.


Like Tree24Likes

Ottawa researchers find new pathway connected to Type 2 diabetes


Closed Thread
 
Shared Thread Thread Tools
Old 03-20-2014, 13:07   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Ottawa researchers find new pathway connected to Type 2 diabetes

CHEO Research Institute - News Releases

Ottawa, ON, March 19, 2014 — Scientists at the Children’s Hospital of Eastern Ontario (CHEO) Research Institute have discovered a cellular pathway that is responsible for keeping blood sugar levels low in obese or pre-diabetic people, and may prevent the onset of Type 2 diabetes. The discovery published this month in a leading journal Nature Cell Biology.

Following a meal, beta cells found in islets of the pancreas secrete insulin that helps to store food energy for future use. The inability of islet beta cells to produce enough insulin leads to diabetes. Unlike other research that has focused on how to replicate beta cells, this study focused on how to make pre-existing beta cells more functional, or better at secreting insulin.

The research team, led by Canada Research Chair Dr. Robert Screaton, senior scientist at the CHEO Research Institute and associate professor at the University of Ottawa, started with a gene “knockout” strategy to remove a protein called SIK2 from all beta cells. They found that mice without SIK2 secrete less insulin during feeding because they fail to turn off a switch protein called p35, which prevents insulin secretion when blood sugar levels are low. The team also found that SIK2 works together with the protein PJA2 to turn off p35.

“We were very excited when we found obese animals had three times the amount of SIK2 in their beta cells, meaning they were working harder to compensate for high blood sugar by turning up SIK2,” said Dr. Screaton. “Diabetic mice have lost this ability to turn up SIK2 and compensation is lost. The SIK2-p35-PJA2 pathway provides us with new targets to try and improve beta cell functionality to prevent and treat Type 2 diabetes.”

newgrange and counsiler like this.
kantim is offline  
Old 03-20-2014, 13:39   #2
Moderator
 
mbuster's Avatar
 
Join Date: Sep 2011
Location: SW Arkansas
Posts: 9,365

Member Type
Type 2
Diagnosed in Feb. 2012

11311 likes received
6596 likes given
Default

A new medicine to pedal?

iPhone using DF app

__________________
Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (02/2020)
TC 183 LDL 102 HDL 65 TG 52 (02/20/2020)
Supplemental vitamins and electrolytes
65 YY Love the LCHF diet. The cheese goes well with my whine

updated 10/12/2020
mbuster is online now  
Old 03-20-2014, 14:52   #3
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default

The reason I post all the research I find interesting even if is drug related is because not everyone is able to solve there diabetic problems with just diet. If they can find a more effective safer drug then that is good even if one may never need it. It may always benefit a lot of people. Also the more they learn about the disease even if they are just looking for a new drug, the better is for all who suffer or may suffer from the disease. I know we will like more research not directed at drug development but the truth is that is were money is and not all is the fault of the researchers. I know of many people with diabetes with a lot of complications that aren't willing to change their lifestyles no matter how easy a LCHF diet and some exercise may be to follow. The same way many people will not leave alcohol or cigarettes even if it's killing them. Carbs and food can create very powerful addictions that may be complicated by genetics and hormonal metabolic problems that aren't all yet well understood.

kantim is offline  
 
Old 03-20-2014, 14:54   #4
Senior Member
 
Join Date: Jul 2011
Location: California, USA
Posts: 3,076

Member Type
Type 2
Diagnosed in 2009

4566 likes received
542 likes given
Default

What if you have plenty of insulin but your primary problem is insulin resistance?

BTW, isn't that the majority of T2s?

Shanny, Daytona and silvertiger like this.
__________________
Salim Morgan, T2
66 Years
DX: 9/2009 A1C=10.7
A1C 2/2010: 6.7 (DX + 4 months)
A1C 5/2010: 6.0 (DX + 8 months)
A1C 8/2010: 5.7 (DX + 11 months)
A1C 11/2010: 5.1 (DX + 14 months)
A1C 9/2011: 5.6 (DX + 2 years)
A1C 7/2012: 5.5 (DX + 2 years 10 months)
A1C 1/2019: 5.5
Diet: Approximately C:10;P:15;F:75 (as % calories)
Exercise: Not much. Stairs at home & work.
NO MEDS, No Highs, No Lows
Grandkids: 22
smorgan is offline  
Old 03-20-2014, 15:32   #5
Moderator
 
mbuster's Avatar
 
Join Date: Sep 2011
Location: SW Arkansas
Posts: 9,365

Member Type
Type 2
Diagnosed in Feb. 2012

11311 likes received
6596 likes given
Default

Not knocking the post, I just associate the word treat with 'pills for sale'. I read all your posts and missed them during your absence.

I have low hopes for cure but high hopes for prevention. I just think they should be more focused on looking at how diet allows/prevents sicknesses.

iPhone using DF app

kantim likes this.
__________________
Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (02/2020)
TC 183 LDL 102 HDL 65 TG 52 (02/20/2020)
Supplemental vitamins and electrolytes
65 YY Love the LCHF diet. The cheese goes well with my whine

updated 10/12/2020
mbuster is online now  
Old 03-20-2014, 15:48   #6
Senior Member
 
Join Date: Mar 2014
Location: St Louis, MO
Posts: 171

Member Type
Type 2
Diagnosed in 2014

212 likes received
290 likes given
Default

If we assume insulin resistance is at the root of this thing, I have a question that hopefully has been asked and answered already. Don't cells in the body turn over every so often? For example, isnt the A1C test a "three month" test because red blood cells last about three months? My understanding was that a definition of cancer cells is that unlike most cells, they tend not to die off.

What I'm wondering about is this - why are new cells in the body of a well controlled type 2 diabetic, who is not on insulin, insulin resistant? I guess from a very simplistic perspective, I'm thinking new cells should not be "born" insulin resistant.

Wondering if there isn't some mechanism in the body telling these new cells to be insulin resistant.

newgrange likes this.
sleepies is offline  
Old 03-20-2014, 16:47   #7
Senior Member
 
Join Date: Feb 2014
Location: Bay Area, CA, USA
Posts: 801

Member Type
Type 2
Diagnosed in 2013

1172 likes received
358 likes given
Default

I would think it's the coding in the cells. After all, they all get their coding from the same source, the cells that have gone before them.

Shanny and sleepies like this.
__________________
Never anger a Dragon, for you are crunchy and go well with brie.

Stats:
Dx 10/2013 : 12/2013 : 4/2014 : 10/2014 :5/2015
A1c 8.0 : 5.6 : 5.5 : 5.5 : 5.5
FBG 180 : 97 : 109 : 97
TCh 196 : 146 : 208 : 211
Tri 220 : 107 : 108 : 96
HDL 48 : 47 : 58 : 61
LDL 104 : 78 : 128 : 130
LDL Pattern A!

LCHF and striving for ketosis since Feb 2014.
Next testing due 11/2015.

Dosing with:
2000mg Metformin
Daily mulitvitamin
Daily antihistamine
Nightly magnesium
jademuffin is offline  
Old 03-20-2014, 17:02   #8
Senior Member
 
ICDogg's Avatar
 
Join Date: Jan 2014
Location: Philadelphia, United States
Posts: 704

Member Type
Type 2
Diagnosed in 1995

1022 likes received
802 likes given
Default

Quote:
Originally Posted by smorgan View Post
What if you have plenty of insulin but your primary problem is insulin resistance?

BTW, isn't that the majority of T2s?
Exactly. This seems completely the wrong approach.

sleepies likes this.
__________________

View ICDogg's full Diabetes Forum profile here.
ICDogg is offline  
Old 03-20-2014, 18:34   #9
Senior Member
 
Join Date: Jul 2011
Location: California, USA
Posts: 3,076

Member Type
Type 2
Diagnosed in 2009

4566 likes received
542 likes given
Default

Quote:
Originally Posted by sleepies View Post
If we assume insulin resistance is at the root of this thing, I have a question that hopefully has been asked and answered already. Don't cells in the body turn over every so often? For example, isnt the A1C test a "three month" test because red blood cells last about three months? My understanding was that a definition of cancer cells is that unlike most cells, they tend not to die off.

What I'm wondering about is this - why are new cells in the body of a well controlled type 2 diabetic, who is not on insulin, insulin resistant? I guess from a very simplistic perspective, I'm thinking new cells should not be "born" insulin resistant.

Wondering if there isn't some mechanism in the body telling these new cells to be insulin resistant.
Red blood cells die and are replaced about every 3 months. Different cells have different lifespans. I haven't looked at this in detail, but I did read that the nerves in the feet which often "tingle" in uncontrolled T2s are generated in the hip region and take three years to move down to the feet, so clearly they live at least that long.

Also, whatever caused the IR in the first place would probably still be there when the new cells come along. Sure wish we knew exactly what THAT is.

sleepies likes this.
__________________
Salim Morgan, T2
66 Years
DX: 9/2009 A1C=10.7
A1C 2/2010: 6.7 (DX + 4 months)
A1C 5/2010: 6.0 (DX + 8 months)
A1C 8/2010: 5.7 (DX + 11 months)
A1C 11/2010: 5.1 (DX + 14 months)
A1C 9/2011: 5.6 (DX + 2 years)
A1C 7/2012: 5.5 (DX + 2 years 10 months)
A1C 1/2019: 5.5
Diet: Approximately C:10;P:15;F:75 (as % calories)
Exercise: Not much. Stairs at home & work.
NO MEDS, No Highs, No Lows
Grandkids: 22
smorgan is offline  
Old 03-20-2014, 18:56   #10
Senior Member
 
Join Date: Mar 2014
Location: St Louis, MO
Posts: 171

Member Type
Type 2
Diagnosed in 2014

212 likes received
290 likes given
Default

Quote:
Originally Posted by smorgan View Post
Red blood cells die and are replaced about every 3 months. Different cells have different lifespans. I haven't looked at this in detail, but I did read that the nerves in the feet which often "tingle" in uncontrolled T2s are generated in the hip region and take three years to move down to the feet, so clearly they live at least that long.

Also, whatever caused the IR in the first place would probably still be there when the new cells come along. Sure wish we knew exactly what THAT is.
From developing "handcuff neuropathy" a while back, I know the nerves in your wrist and hand grow back at about the rate of 1/4 inch a week. If nerves in the leg regrow at the same rate, it could take a few years.

And yea, I guess we are wondering the same thing when it comes to IR. Is it something that is "passed down" between cells? Or is it something else that maybe the endocrine system is dumping into the blood stream? Or maybe our insulin levels are permanently elevated, even though our blood sugar is down?

Wondering if anyone has done research in this space?

sleepies is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Researchers Find New Clues In Hunt For Heredity In Type 2 Diabetes kantim Diabetes News 0 03-22-2013 12:36
Researchers find Mediterranean diet is best for diabetics Editor Diabetes News 0 02-14-2013 11:21
Researchers find that vitamin D may reduce the risk of adult type 1 onset diabetes Editor Diabetes News 0 02-08-2013 10:50
Researchers Pursue Multiple Approaches To Type 1 Diabetes george jacob Diabetes Medication and Supplies 0 02-22-2008 12:50
Researchers Pursue Multiple Approaches To Type 1 Diabetes george jacob Diabetes News 0 02-21-2008 11:51

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 18:23.




Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.