Mgat5 is potential target to treat diabetes and obesity

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Start Here > Diabetes News

Diabetes News The Diabetes News section is a place to share any new stories or information you have come across related to Diabetes for the rest of the forum to share and discuss. If you have seen or read about new medication, diabetes treatments, medical breakthroughs or any interesting stories of personal interest then please post and discuss them here. From time to time we will take some of the Diabetes News stories from this section and write them up in our Diabetes Blog.


Like Tree1Likes
  • 1 Post By kantim

Mgat5 is potential target to treat diabetes and obesity


Closed Thread
 
Shared Thread Thread Tools
Old 05-01-2014, 12:41   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Mgat5 is potential target to treat diabetes and obesity

Targeting glucagon, the other half of the blood glucose equation -- Mgat5 is potential target to treat diabetes and obesity | Lunenfeld-Tanenbaum

TORONTO -- A possible therapeutic target for control of blood glucose in the treatment of type 2 diabetes and obesity has been identified by Dr. Anita Johswich and her colleagues. Their findings were published in Journal of Biological Chemistry, online April 2014.

An imbalance in the competing action of insulin and glucagon is widely viewed as a critical factor in onset of type 2 diabetes, a relentlessly increasing health problem. A delicate balance between two hormones controls blood glucose levels day and night. After a meal, blood glucose rises, which stimulates insulin release and promotes glucose uptake and metabolism. During periods of fasting the blood glucose drops and is countered by glucagon, which stimulates glucose synthesis (gluconeogenesis) to re-supply levels of circulating glucose.

Dr. Johswich’s study began with the intriguing observation that compared to wild type mice, mice deficient in the Mgat5 gene are leaner, with lower blood glucose and resistance to high calorie diets. Mice lacking the Mgat5 gene had a minimal response to glucagon which was found to be due to a requirement for the action of Mgat5 on the liver glucagon receptor. Dr. Johswich is a post-doctoral fellow in the lab of Dr. Jim Dennis at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, in Toronto, Canada.

Dr. Johswich and colleagues also found evidence for a positive feedback loop between Mgat5 and a glucose metabolism-related pathway termed the hexosamine biosynthesis pathway (HBP) that acts to amplify responses to glucagon. Mgat5 and HBP work together to increase glucagon receptor sensitivity, thereby enhancing glucose production by the liver.

In a nutrient-rich environment typical of the developed world today, carbohydrate-rich diets and positive feedback to glucagon signaling increases gluconeogenesis leading to chronic hyperglycemia, obesity, and insulin resistance.

The results suggest that selective inhibitors of Mgat5 and/or HBP may represent novel therapeutic approaches to restore normal glucose control in the setting of type 2 diabetes.

sleepies likes this.
kantim is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Scientists find potential target for treating mitochondrial disorders kantim Diabetes Complications 0 03-28-2014 13:15
Potential new therapeutic target identified to control high blood sugar kantim Diabetes News 0 03-20-2014 13:10
Scientists discover potential new way to treat anxiety kantim Diabetes Forum Lounge 1 08-05-2013 14:31
Vitamin E Identified as Potential Weapon Against Obesity kantim Diabetes Treatment 0 04-24-2013 13:27
A New Protein Target for Controlling Diabetes kantim Diabetes News 0 04-14-2013 12:46

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 15:29.




Powered by vBulletin®
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2019 DragonByte Technologies Ltd.