Elevated Liver Enzyme Levels Linked to Higher Gestational Diabetes Risk

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Elevated Liver Enzyme Levels Linked to Higher Gestational Diabetes Risk


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Old 05-03-2014, 12:47   #1
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Default Elevated Liver Enzyme Levels Linked to Higher Gestational Diabetes Risk

Kaiser Permanente Share | Elevated Liver Enzyme Levels Linked to Higher Gestational Diabetes Risk

“Several biomarkers appear to be associated with the risk of gestational diabetes,” said Monique M. Hedderson, PhD, senior author of the study and research scientist with the Kaiser Permanente Division of Research in Oakland, Calif. “This study and others we’ve done provide evidence that women who develop gestational diabetes have metabolic abnormalities even before pregnancy. In the future, we could potentially try to prevent gestational diabetes by intervening before women get pregnant.”

(snip)

Researchers examined the medical records of 256 women who developed gestational diabetes during pregnancy and compared them with 497 women who did not. Those studied had voluntarily given blood samples between 1985 and 1996 during routine care and subsequently delivered an infant in Kaiser Permanente’s Northern California region.

After adjusting for numerous possible confounding factors, including body mass index and alcohol use, the researchers found that women in the highest quartile of GGT had nearly twice the risk of subsequent gestational diabetes than those in the lowest quartile. No associations were found with two other commonly monitored liver enzymes, alanine aminotransferase and aspartate aminotransferase.

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