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Actos News


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Old 03-25-2011, 13:44   #1
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Default Actos News

A daily pill given to people at high risk of developing diabetes slashed their odds of getting it by more than 70 percent, a national, San Antonio-led study has found.

The drug, piaglitazone — sold as Actos — demonstrated the most powerful ability yet to prevent the disease over currently recommended strategies — including diet and exercise — and metformin, originally sold as Glucophage.

However, piaglitazone can have significant side effects — including fluid retention, which in some cases can lead to heart failure; weight gain; and a slightly increased risk of bone fractures. It's also expensive, at about $10 per pill. A generic version might be available as early as next year.

The study, published in today's New England Journal of Medicine, followed 602 prediabetics — those who already have abnormal blood sugar and are insulin-resistant, but not quite at the levels to trigger a diagnosis of Type 2 diabetes — for 2½ years. About 130 of the participants were in San Antonio.

“It was a very large study to see if a particular drug, Actos, could stop the progression of this prediabetic state on to diabetes in high-risk people, and I think the results are pretty dramatic,” said Dr. Ralph DeFronzo, professor of medicine at the University of Texas Health Science Center, the lead author of the study.

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Old 03-25-2011, 14:16   #2
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Buy their stock. I would not buy their drug.

It increases spontaneous fractures in women post-meno, for one thing. SPONTANEOUS fractures? My endo took me off it.

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Old 03-25-2011, 15:49   #3
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That sounds scary. What the heck does "spontaneous fractures" mean anyway? You'll have a bone crack for no apparent reason?
I took Actos a long time ago when I was first diagnosed. It was about $200.00 for a month's supply then.

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Buy their stock. I would not buy their drug.

It increases spontaneous fractures in women post-meno, for one thing. SPONTANEOUS fractures? My endo took me off it.

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Old 03-25-2011, 15:52   #4
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Yup ... just ca-rack! Not caused by any impact, whatsoever!

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Old 03-25-2011, 18:09   #5
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Originally Posted by Oneman2watch View Post
A daily pill given to people at high risk of developing diabetes slashed their odds of getting it by more than 70 percent, a national, San Antonio-led study has found.

The drug, piaglitazone — sold as Actos — demonstrated the most powerful ability yet to prevent the disease over currently recommended strategies — including diet and exercise — and metformin, originally sold as Glucophage.

However, piaglitazone can have significant side effects — including fluid retention, which in some cases can lead to heart failure; weight gain; and a slightly increased risk of bone fractures. It's also expensive, at about $10 per pill. A generic version might be available as early as next year.

The study, published in today's New England Journal of Medicine, followed 602 prediabetics — those who already have abnormal blood sugar and are insulin-resistant, but not quite at the levels to trigger a diagnosis of Type 2 diabetes — for 2½ years. About 130 of the participants were in San Antonio.

“It was a very large study to see if a particular drug, Actos, could stop the progression of this prediabetic state on to diabetes in high-risk people, and I think the results are pretty dramatic,” said Dr. Ralph DeFronzo, professor of medicine at the University of Texas Health Science Center, the lead author of the study.
I will never take Actos again. I never felt good while being on it and I was retaining a terrible amount of fluid. I wouldn't take it even if it was free.

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Old 03-26-2011, 13:17   #6
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Default Actoplus Met

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I will never take Actos again. I never felt good while being on it and I was retaining a terrible amount of fluid. I wouldn't take it even if it was free.
That's what I take and it's a completly different drug. I hope because I looked it up and they where different drugs.
ActoplusMet.

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Old 03-26-2011, 14:25   #7
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I just recently got put on Actos... haven't had any issues with retaining fluid as yet, and feel fine so far. The fracture thing scares me though, as well as the article on Blood Sugar 101. Having never broken a bone doesn't mean I want to take a med that increases the chance.
Probably going to check with the doctor about other options.

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Old 03-26-2011, 17:15   #8
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That's what I take and it's a completly different drug. I hope because I looked it up and they where different drugs.
ActoplusMet.
It can't be a different drug, Actos is still under its patent. The only difference is you are combining Actos and Metformin.

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Old 03-26-2011, 18:02   #9
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Quote:
Originally Posted by foxl View Post
Yup ... just ca-rack! Not caused by any impact, whatsoever!
May be something like Brittlebones! Thats really scary. I had to take pioglitazone for some time on doc's advice but I started to put on lot of weight and water retention in joints. After stopping I came to normal size but my joints still swell sometimes and pain also. That drug should be taken out of market like Avandia.

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Old 03-26-2011, 23:07   #10
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Default Actos Vs Actoplus

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Originally Posted by breezeonby View Post
It can't be a different drug, Actos is still under its patent. The only difference is you are combining Actos and Metformin.
Im serious I looked it up its called "actoplusmet" not actos, acto, not (actos) I have also been on this met for two years now, the only side affect I had was blurry vison at first but that was gone after a few days. I always feel fine, I pray this is not the actos drug they are refering to. people do you mind telling me how the metfor med works? I could always switch.

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