Diabetes and Aspirin?

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Diabetes and Aspirin?


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Old 03-28-2012, 23:38   #1
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Default Diabetes and Aspirin?

I'm totally confused after reading this:

FRIDAY, March 23 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March 16 in Diabetes.

Noting that aspirin has a modest influence on cardiovascular events in T2DM, Roberto Cangemi, M.D., Ph.D., from the Sapienza University of Rome, and colleagues investigated the effect of aspirin on platelet isoprostanes in patients with T2DM. Fifty aspirin-treated and 50 untreated T2DM patients were compared with 100 patients without diabetes, matched for age, gender, atherosclerosis risk factors, and aspirin treatment. In 36 aspirin-free patients, with and without diabetes, a seven-day treatment with aspirin was performed.

The researchers found that in patients with diabetes versus those without, and in aspirin-treated versus untreated diabetes patients, higher platelet recruitment, platelet isoprostane, and activation of the catalytic subunit of reduced NAD phosphate oxidase (NOX2) were seen. In all aspirin-treated patients, platelet thromboxane (Tx) A2 was inhibited. In those with and without diabetes, aspirin inhibited platelet TxA2 similarly in the interventional study. A parallel increase was seen in platelet recruitment, isoprostane levels, and NOX2 activation in patients with diabetes, whereas no change was seen in those without diabetes.

"We provide evidence that, in T2DM patients, low-dose aspirin enhances platelet isoprostanes as a consequence of NOX2-generated reactive oxidant species upregulation," the authors write. "This effect mitigates the antiplatelet effect of aspirin and may account for its lower clinical efficacy in T2DM compared with other atherosclerotic settings."

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Old 03-28-2012, 23:45   #2
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So, aspirin may not work as well in T2D's in its anti-platelet-aggregation effect, and this gives an insight into the biochemistry.

Doesn't say it does not work, just works less. Shrug.

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Old 03-28-2012, 23:47   #3
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Quote:
Originally Posted by foxl View Post
So, aspirin may not work as well in T2D's in its anti-platelet-aggregation effect, and this gives an insight into the biochemistry.

Doesn't say it does not work, just works less. Shrug.
Is that all it says???? LOL Sounded really serious!

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Old 03-28-2012, 23:49   #4
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That is about as useful as saying the wind will blow on the high plains today. Well DUH!

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Old 03-28-2012, 23:50   #5
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Quote:
Originally Posted by Diana View Post
Is that all it says???? LOL Sounded really serious!
He who dramatizes gets the grant renewal.

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Old 03-28-2012, 23:58   #6
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Quote:
Originally Posted by foxl

He who dramatizes gets the grant renewal.
That's the proverbial nail on the head

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Old 03-29-2012, 00:10   #7
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Confused, eh? All I know is my eyes began to glaze over . . .




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Old 03-29-2012, 00:37   #8
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This might help Shanny. This is one reason I will continue my aspirin regimen.
Can Taking Aspirin Once a Day Reduce Risk of Cancer, Stroke, and More? - The Daily Beast

This article is a lot easier to read.

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Old 03-29-2012, 03:05   #9
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I also read an article last year about aspirin reducing inflammation and increasing the environment with in ones pancreas to aid in insulin production. I started out with 3, 325 mg pills a day, worked my way up to 6 a day. Maintained that for several days until the ringing in my ears was to bad to continue. Dropped backed to 4-5 a day for nearly 2 weeks. I know take 3 a day, every day. Result was reduced spike PP, reduced my baseline by 5 -10 pts. 5 pts may not sound like much at first, but I know stay in the mid to low 80's instead of 90's.

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Old 03-29-2012, 10:50   #10
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I found the article I was refering to.

Interesting article:

Aspirin stimulates insulin and glucagon secretion and increases glucose tolerance in normal and diabetic subjects.
Abstract

Normal subjects and patients with adult-onset diabetes received 10 gm. of aspirin in four days. On the fourth day, the fasting serum glucose and the glucose response to oral glucose were decreased in both groups. These changes were associated with increased levels of serum insulin and pancreatic glucagon, although the glucagon responses to oral glucose were unchanged. In the diabetic patients, aspirin therapy was followed by a decreased glucose response to I.V. glucose and by the appearance of an early insulin peak, which could not be demonstrated before treatment. Aspirin did not affect the I.V. glucose tolerance in normal subjects, although it did enhance the early insulin peak. A decrease in the fasting levels of free fatty acids was noted in both groups, whereas the fasting level of triglycerides decreased only in the diabetic patients. Cholesterolemia did not change in either group. A few preliminary observations indicate that, in normal subjects, ibuprofen and ketoprofen, two other presumed prostaglandin inhibitors, did not affect fasting glycemia, glucose tolerance, or the insulin response to glucose. No changes were noted after the administration of placebo.

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