*Medications To Lower Cholesterol*

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Community > Diabetes Treatment

Diabetes Treatment As there is currently no cure for the chronic, Diabetes mellitus – the emphasis must be on treatment and management to avoid complications. Please use this section to discuss how you carefully control and manage your Diabetes. Please let us know what is and isn’t working for you. Feel free to discuss all areas of treatment and management of Diabetes including diet, exercise, weight loss, insulin usage, oral drugs and more.


*Medications To Lower Cholesterol*


Closed Thread
 
Shared Thread Thread Tools
Old 10-04-2007, 19:23   #1
Senior Member
 
Join Date: Sep 2007
Location: Ontario Canada
Posts: 1,077

Diagnosed in 1961-now 50+ years with Diabetes

23 likes received
Default *Medications To Lower Cholesterol*

Cholesterol-Lowering Drugs

AHA Recommendation

Drug therapy can be considered for patients who — in spite of adequate dietary therapy, regular physical activity and weight loss — need further treatment for elevated blood cholesterol levels. The guidelines for those
who qualify are...

LDL Cholesterol

- Level for Drug Consideration (after therapeutic life changes)
- Goal of Therapy

Without coronary heart disease and with fewer than two risk factors+

- 190 mg/dL or higher*
- less than 160 mg/dL

Without coronary heart disease and with two or more risk factors 160 mg/dL or higher

- less than 130 mg/dL

With coronary heart disease

- 130 mg/dL or higher**
- 100 mg/dL or less

* Drug therapy is optional for LDL-C 160–189 mg/dL (after dietary therapy). For persons with severe elevations of LDL-C (e.g., >/= 220 mg/dL), drug therapy can be started together with dietary therapy.

** In coronary heart disease patients (or those with 2+ risk factors) with LDL cholesterol levels of 100 to 129 mg/dL, the physician should exercise clinical judgment in deciding whether to begin drug treatment.

In some cases, a physician may decide that using cholesterol-lowering drugs at lower LDL cholesterol levels is justified. On the other hand, drug therapy may not be appropriate for some patients who meet the above criteria. This may be true for elderly patients.

What drugs are most commonly used to treat high cholesterol?

The drugs of first choice for elevated LDL cholesterol are the HMG CoA reductase inhibitors, e.g., atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. Statin drugs are very effective for lowering LDL cholesterol levels and have few immediate short-term side effects.

-They are easy to administer, have high patient acceptance and have few drug-drug interactions.

-Patients who are pregnant, have active or chronic liver disease, or who are allergic to statins shouldn't use statin drugs.

-The most common side effects are gastrointestinal, including constipation and abdominal pain and cramps. These symptoms are usually mild to severe and generally subside as therapy continues.

Another class of drugs for lowering LDL is the bile acid sequestrants — colesevelam, cholestyramine and colestipol — and nicotinic acid (niacin). These have been shown to reduce the risk for coronary heart disease in controlled clinical trials. Both classes of drugs appear to be free of serious side effects. But both can have troublesome side effects and require considerable patient education to achieve adherence. Nicotinic acid is preferred in patients with triglyceride levels that exceed 250 mg/dL because bile acid sequestrants tend to raise triglyceride levels.

Niacin (nicotinic acid) comes in prescription form and as “dietary supplements.” Dietary supplement niacin is not regulated by the U.S. Food and Drug Administration (FDA) the same way that prescription niacin is. It may contain widely variable amounts of niacin — from none to much more than the label states. The amount of niacin may even vary from lot to lot of the same brand.

-Dietary supplement niacin must not be used as a substitute for prescription niacin. It should not be used for cholesterol lowering because of potentially very serious side effects.

What other drugs are available to treat high cholesterol?

Other available drugs are gemfibrozil, probucol and clofibrate. Gemfibrozil and clofibrate are most effective for lowering high triglyceride levels. They moderately reduce LDL cholesterol levels in hypercholesterolemic patients, but the FDA hasn't approved them for this purpose. Probucol also moderately lowers LDL levels. It has FDA approval for this purpose.

If a patient doesn't respond adequately to single drug therapy, combined drug therapy should be considered to further lower LDL cholesterol levels. For patients with severe hypercholesterolemia, combining a bile acid sequestrant with either nicotinic acid or lovastatin has the potential to markedly lower LDL cholesterol. For hypercholesterolemic patients with elevated triglycerides, nicotinic acid or gemfibrozil should be considered as one agent for combined therapy.


Last edited by Terrie; 10-04-2007 at 19:37.
Terrie is offline  
Old 06-03-2008, 19:54   #2
Active Member
 
prozacwoman's Avatar
 
Join Date: Jun 2008
Location: USA, Tennessee
Posts: 10


Question

Is it just me, or is an LDL level under 100 almost impossible? Does anybody know how hard it's going to be to get to that level? This is one of the things that's seriously bumming me out about all this. It just seems to be such an impossibly low number...

xo,

__________________
ProzacWoman
prozacwoman is offline  
Old 06-06-2008, 07:35   #3
Senior Member
 
Join Date: Sep 2007
Location: Ontario Canada
Posts: 1,077

Diagnosed in 1961-now 50+ years with Diabetes

23 likes received
Default

Quote:
Originally Posted by prozacwoman View Post
Is it just me, or is an LDL level under 100 almost impossible? Does anybody know how hard it's going to be to get to that level? This is one of the things that's seriously bumming me out about all this. It just seems to be such an impossibly low number...
xo,

Hi PW:

I Hate to say it but getting and staying healthy is Hard work, as you probably noticed. I did find that some Dr's and labs have slightly different numbers. There is a name for it, but I can't remember what it is right now.

To the Dr. One means, (if the numbers aren't right on :P ) the exact numbers and the other means, (in the area, give the Patient a break if he/she isn't dying ) j/k So I don't fret too much about getting the "exact number" but certainly do try to get somewhere's in Good or close to Good area.


Here is the conversion chart: U.S. and Canadian/UK

Cholesterol/Lipids Conversion - Healing Heart Foundation website


I hope that you don't get the stomach flu that I managed to get. Not Fun!

Terrie is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Hello- High Numbers, How can I lower them? Annie50 New Member Introductions 19 07-17-2011 03:29
*Diabetes, Cholesterol And Cad* Terrie Diabetes Symptoms 0 05-23-2008 12:20
Medications That Lower/Raise Blood Sugar Levels Richard157 Diabetes Treatment 0 12-19-2007 19:30
*More On Cholesterol...* Terrie Diabetes Complications 0 10-02-2007 04:32
*Cholesterol* Terrie Diabetes Complications 0 10-01-2007 17:47

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 20:19.




Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.