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-   -   Questran - cholestyramine - what do you know about it? (https://www.diabetesforum.com/diabetes-treatment/15094-questran-cholestyramine-what-do-you-know-about.html)

VeeJay 04-19-2013 20:49

Questran - cholestyramine - what do you know about it?
 
I have been given a prescription for Questran (cholestyramine) - specifically to help with chonic diarrhea. The doc said that it also helps with cholesterol because it binds with LDL to pass out of the body.

Another benefit is for diabetics (not sure now what I read on how it reduces glucose, but I think that's what it does).

I looked it up on-line and find that it contains 2 sugars - sucrose and maltotextrin, along with aspertame.

So, I'm wondering if anyone has any experience with this or any knowledge of others who have taken it. Does it affect blood sugar levels - to the good like the articles said, or to the bad?

kantim 04-19-2013 22:28

The sugar is because it doesn't taste very good, so to make it palatable they got to add something. It helps with diarrhea and it lower cholesterol. It reduce the bile. For a temporary use is not much problem other than the small portion of carbs. For cholesterol they were the first before statins they don't do much in term of cholesterol or reducing CVD.

Mary, 04-20-2013 00:27

I was on that for a while, after I had my gallbladder removed. I suffered with chronic diarrhea after that surgery. I remember, I used to mix it with water. Even back then, I hated orange juice. It wasn't too bad with water. I chugged it every day. It definitely stops the diarrhea. My surgeon explained to me that it rebuilds the lining in your stomach, and foods that give you diarrhea no longer do. You usually only take it for a short time. From what I remember, I took it for several weeks. I went out to breakfast with my mom one morning, and ordered foods that would normally send me running. I ate them, and then realized I never took my medicine that morning. I then realized the lining must have been rebuilt, like the doc. said. Sorry I can't advise you on the BS effect, but it will definitely solve the diarrhea issue, especially if it's the result of gallbladder removal. You will be SO much happier, trust me!!

VeeJay 04-20-2013 02:29

Thanks Mary for that informative reply.

The doc is doing several tests. Her first thought was a parasite, but I haven't been out of the country for years. I also don't have a gall bladder - she says if the Questran helps it would point to that. If neither of these, who knows. I don't know what she's testing my blood for.

foxl 04-20-2013 15:17

I have never been clear if it adsorbs cholesterol or sat fat, before it is absorbed and digested. Neither is a good thing ...

VeeJay 04-20-2013 15:27

She used the word "bind"

She said it binds to the LDL making it ineffective, so to speak.

I wondered, also, about how beneficial this will be with my LCHF way of eating. But, at this point, I'm willing to give it a try for a while. I know I don't have a gallbladder, so there is some impairment in the way my body digests fats. It could be that the action of the Questran would be limited to a certain amount of fats and not all of them. ?????

And it just may be that I will have to back off a bit on the fats and not continue to be in ketosis. I'd have to increase protein because I won't increase carbs. It'll be a juggling act. But it's early days and I'm speculating ahead of my data.

Mary, 04-20-2013 15:29

Foxl,

True, but it really does do wonders if you're suffering. I went thru all kinds of heck after my gallbladder surgery with that, and it was definitely what I would consider a miracle drug, in this respect. I couldn't eat hardly anything without serious stomach issues. :(

smh 04-20-2013 17:09

Quote:

Originally Posted by foxl (Post 156587)
I have never been clear if it adsorbs cholesterol or sat fat, before it is absorbed and digested. Neither is a good thing ...

In the normal digestive process, the bile that is released to help with digesting fats is reabsorbed by the small intestine, to ultimately be re-used. Cholestyramine binds with the bile so it is excreted instead of reabsorbed. Since bile is made partly from cholesterol, this requires the use of more cholesterol to make more bile, thereby reducing cholesterol levels.

If, for whatever reason, the bile salts get down into the large intestine, they have an irritating effect, and can cause diarrhea.

I had seen where some doctors had prescribed cholestyramine or a similar product for patients to help deal with the side effects of metformin. When I went looking for reasons why they might work for this, I found the abstracts of a couple of studies; one was specifically to determine why metformin had this effect, and was conducted with human subjects. The other used rats or mice, but was to determine why metformin (and I had never read this) had a slight cholesterol lowering effect. Both studies showed that metformin interferes with the reabsorption of the bile salts in the small intestine, allowing them to enter in the large intestine, causing the problem.

VeeJay 04-20-2013 19:28

That's interesting!

VeeJay 04-20-2013 19:58

Quote:

Originally Posted by smh (Post 156612)
If, for whatever reason, the bile salts get down into the large intestine, they have an irritating effect, and can cause diarrhea.

I wonder if, because I don't have a gall bladder and bile is constantly entering the small intestines in small amounts, even when there's no fats there to work on, that it would be reasonable to expect that some bile is always making its way to the large intestines.

I am really anxious now to try the Questran to see if it works. Will start it day after tomorrow - a Monday (don't want to try anything new over the weekend.)


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