Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Community > Diabetes Treatment

Diabetes Treatment As there is currently no cure for the chronic, Diabetes mellitus – the emphasis must be on treatment and management to avoid complications. Please use this section to discuss how you carefully control and manage your Diabetes. Please let us know what is and isn’t working for you. Feel free to discuss all areas of treatment and management of Diabetes including diet, exercise, weight loss, insulin usage, oral drugs and more.


Like Tree4Likes
  • 1 Post By kantim
  • 1 Post By wpfegis
  • 2 Post By cathyy

Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade


Closed Thread
 
Shared Thread Thread Tools
Old 05-21-2013, 14:32   #1
Senior Member
 
Join Date: Jun 2012
Location: USA
Posts: 1,288

Member Type
Type Pre
Diagnosed in 2005

1124 likes received
692 likes given
Default Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade

(Anyone that have ever taken tramadol has notice this effect?)

Tramadol enhances hepatic insulin sensitivity... [Brain Res Bull. 2005] - PubMed - NCBI

Clinical observation found that tramadol, mu opioid receptor (MOR) agonist and serotonin (5-HT) reuptake inhibitor, has a hypoglycemic effect in type 2 diabetes patients.

foxl likes this.
kantim is offline  
Old 08-07-2013, 23:22   #2
Junior Member
 
Join Date: Aug 2013
Location: usa
Posts: 1

Member Type
Type 2
Diagnosed in 2010

1 likes received
1 likes given
Default

Yes. I was prescribed/took 200 mg (extended release) once per day for 3 months for pain from a herniated disc. A few days after I started taking tramadol I began having mild hypoglycemic episodes during the day at work. I was able to reduce my Lantus Solostar dosage by 20% and still maintain tight control of my BG levels. After discontinuing tramadol, my fasting BG went up and I had to increase the Lantus dosage to the previous dosage.

In addition to substantial pain relief and increased insulin sensitivity, my mood greatly increased and all symptoms of depression were ameliorated on tramadol. It is chemically similar to Effexor and is sometimes prescribed off-label for depression.

I did experience minor withdrawal symptoms upon discontinuation (flu-like symptoms and restlessness in bed at night). These passed after a couple of days. I've had worse hangovers from drinking (when I was younger, I don't drink much any more). But, a quick "Google" of "Tramadol Withdrawal" will find many horror stories. But I suspect many of the stories are from people who abused tramadol or are "drug naive".

As with any medication there are pros and cons which should be considered. I am strongly considering talking to my doctor about taking tramadol on a continuing basis. I really like this drug, perhaps a little too much, which concerns me.

I am currently gathering information on tramadol, which brought me to this forum. And would appreciate any input further substantiating or contradicting my personal experience.

foxl likes this.
wpfegis is offline  
Old 08-08-2013, 19:22   #3
Senior Member
 
Join Date: Aug 2010
Location: Michigan
Posts: 213

Member Type
Type 2
Diagnosed in 2001

86 likes received
43 likes given
Send a message via Yahoo to cathyy Send a message via Skype™ to cathyy
Default

Very interesting! I have been doing a lot of blood sugar testing lately. I have a usual morning reading in the 130-145 range - dawn phenomenon. I took tramadol last night at bedtime, as well as having a 15 gram snack of crackers and sugarfree peanut butter. My morning blood sugar was 104!!! So, yeah, looks like confirmation of your personal observation.

foxl and wpfegis like this.
__________________
Diagnosis: Type 2 2001?

Metformin 1000mg bid
Ranitidine 150 mg qd
Losartan 50 mg qd
Loratadine 10 mg qd
Pulmicort 180 mcg bid
Fluticasone 50 mcg qd
Ventolin 2 puffs prn
Tramodol 50 mg prn

A1C 6.6

Cinnamon, 1000 mg bid
Turmeric, 2000 mg qd
Vitamin D3 5000 mg qd
Fish oil 3000mg qd
cathyy is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Insulin sensitivity, and β-cell function in relation to hemoglobin A1C kantim Diabetes News 0 04-23-2013 22:46
Ginger Supplementation May Improve Insulin Sensitivity in Type 2 Diabetics kantim Diabetes News 7 04-11-2013 15:10
Insulin users - does the cold impact sensitivity? onlymep Diabetes Forum Lounge 9 09-27-2012 21:43
insulin sensitivity timmy Diabetes 5 01-26-2012 13:40
How To Figure Insulin Sensitivity Factor breezeonby Diabetes 1 03-31-2010 06:14

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 15:12.




Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.