Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade

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Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade

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Old 05-21-2013, 15:32   #1
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Default Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade

(Anyone that have ever taken tramadol has notice this effect?)

Tramadol enhances hepatic insulin sensitivity... [Brain Res Bull. 2005] - PubMed - NCBI

Clinical observation found that tramadol, mu opioid receptor (MOR) agonist and serotonin (5-HT) reuptake inhibitor, has a hypoglycemic effect in type 2 diabetes patients.

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Old 08-08-2013, 00:22   #2
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Yes. I was prescribed/took 200 mg (extended release) once per day for 3 months for pain from a herniated disc. A few days after I started taking tramadol I began having mild hypoglycemic episodes during the day at work. I was able to reduce my Lantus Solostar dosage by 20% and still maintain tight control of my BG levels. After discontinuing tramadol, my fasting BG went up and I had to increase the Lantus dosage to the previous dosage.

In addition to substantial pain relief and increased insulin sensitivity, my mood greatly increased and all symptoms of depression were ameliorated on tramadol. It is chemically similar to Effexor and is sometimes prescribed off-label for depression.

I did experience minor withdrawal symptoms upon discontinuation (flu-like symptoms and restlessness in bed at night). These passed after a couple of days. I've had worse hangovers from drinking (when I was younger, I don't drink much any more). But, a quick "Google" of "Tramadol Withdrawal" will find many horror stories. But I suspect many of the stories are from people who abused tramadol or are "drug naive".

As with any medication there are pros and cons which should be considered. I am strongly considering talking to my doctor about taking tramadol on a continuing basis. I really like this drug, perhaps a little too much, which concerns me.

I am currently gathering information on tramadol, which brought me to this forum. And would appreciate any input further substantiating or contradicting my personal experience.

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Old 08-08-2013, 20:22   #3
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Very interesting! I have been doing a lot of blood sugar testing lately. I have a usual morning reading in the 130-145 range - dawn phenomenon. I took tramadol last night at bedtime, as well as having a 15 gram snack of crackers and sugarfree peanut butter. My morning blood sugar was 104!!! So, yeah, looks like confirmation of your personal observation.

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