Glucophage or metformin?

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Glucophage or metformin?


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Old 12-12-2014, 20:46   #1
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Default Glucophage or metformin?

Dr. Bernstein is pretty down on the generics, preferring the brand name. Just wondering if anyone has taken the test and found a difference? Or a difference from one generic manufacturer to another? Thanks.

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Old 12-12-2014, 21:16   #2
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In this case I wouldn't hesitate to take the generic. The biggest issue with Glucophage/Metformin is the GI side effects. I've read that it's the inactive ingredients that seem to be the biggest predictor of GI side effects (everyone delicately side steps exactly what those GI side effects are--mainly SEVERE explosive diarrhea).

I've heard of just as many complaints from name brand Glucophage as for the various generics, but I've also heard that some people tolerate some brands better than others. I had horrible side effects on name-brand Glucophage many years ago when I first took it, including the ER version which was sometimes excreted whole (THAT's TMI, I know!).

Currently I'm taking ER Metformin made by Teva, and the side effects are few. I know my HMO buys whatever is least expensive at the time, but if they ever change brands I'll probably shop around for a pharmacy that provides Teva Brand inexpensively because I'm doing very well with it. Different people may have different reactions to the inactive ingredients.

I don't see any point in buying name brand in most cases. Because of my IR, I also have severe polycystic ovarian syndrome (PCOS) and I had big issues with infertility. Back in the days I was trying to conceive, the health insurance would not cover fertility treatments, so I had to pay out of pocket for very expensive drugs. The drug of choice in those days was Clomiphene Citrate which was made by two different companies, neither was generic, they both shared the patent for the exact same formulation, but the company that called it "Serophene" was about 65% less expensive than the company that called it "Clomid". I knew this because the pharmacist told me and then, at my request, called the doctor to change the prescription from Clomid to Serophene and I heard him explain the same to him. Every darn time I had to fill that RX, I had to ask the doctor to rewrite it from Clomid to Serophene. Why? Because his office was filled with Clomid mugs, and Clomid paper pads, and he wrote his prescriptions with a pen that said Clomid on it. He never remembered Serophene was the same exact medication and I had to explain it to him time and time again.

I don't want to pay for the little doodads in a doctor's office. Unless there's colorable evidence that a generic is not as good as the name brand, I'll take the generic any time.

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