want to try insulin + metformin - Page 2

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Old 04-09-2015, 04:11   #11
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Originally Posted by diabetes86 View Post
Some one correct me if I am wrong, but the red highlighted above is wrong. insulin is NOT used in the metabolizing of fat.
Actually, insulin has multiple components of action.
Originally Posted by http://emedicine.medscape.com/article/2089224-overview#aw2aab6b2
Insulin is an anabolic hormone that promotes glucose uptake, glycogenesis, lipogenesis, and protein synthesis of skeletal muscle and fat tissue through the tyrosine kinase receptor pathway. In addition, insulin is the most important factor in the regulation of plasma glucose homeostasis, as it counteracts glucagon and other catabolic hormones—epinephrine, glucocorticoid, and growth hormone.
Or here's a quote with smaller words:
Originally Posted by http://science.howstuffworks.com/life/cellular-microscopic/fat-cell2.htm
Insulin acts on many cells in your body, especially those in the liver, muscle and fat tissue. Insulin tells the cells to do the following:
Absorb glucose, fatty acids and amino acids
Stop breaking down glucose, fatty acids and amino acids; glycogen into glucose; fats into fatty acids and glycerol; and proteins into amino acids
Start building glycogen from glucose; fats (triglycerides) from glycerol and fatty acids; and proteins from amino acids
The activity of lipoprotein lipases depends upon the levels of insulin in the body. If insulin is high, then the lipases are highly active; if insulin is low, the lipases are inactive.
Just in case anyone is interested. But not crucial to this discussion

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Old 04-09-2015, 13:49   #12
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From what I have read here of those who are starting insulin, their dose is purposely small so that they can slowly raise the amount to match up their need. One doesn't start out with "a lot of insulin" at first. The goal is to not "go hypo" at all.

"Start slow and learn as you go."

The details of managing insulin are beyond my remit.
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Last edited by VeeJay; 04-09-2015 at 13:52.
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Old 04-10-2015, 17:34   #13
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Insulin is a fat storing hormone and as such, you can indeed gain weight IF you are not careful. In my case the doctor who diagnosed me gave me the typical ADA recommendations and I did gain weight and a lot of it. After I learned how to count carbs and match my insulin dose to my food intake, the weight gain stopped. However losing the weight I initially gained has been an ongoing struggle. My advice would be to watch your carbs, match your insulin dose to the food you eat and don't forget to add exercise into your daily activities if your physical condition permits.

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Old 07-04-2015, 00:06   #14
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Default Insulin & Metformin

Hi All,
I posted a while back, asking what your thoughts of Metformin & Insulin BUT now I would appreciate your feedback from anyone using Insulin & Metformin to control T2 DM. Please share your experiences from the begining of treatment Metformin & Insulin & it's progress, mishaps if any. I have not switched over to this treatment yet, hopefully soon. Please tell me how you felt starting this treatment, eating habits, BGL issues, weight issues, your body's response to this regime. Please share as much info as possible, I really look forward to hearing from you. Thank you!

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diet, insulin, insulin dosage, metformin, weight

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