Insulin injection versus beta-cell stimulating drugs

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Community > Diabetes Treatment

Diabetes Treatment As there is currently no cure for the chronic, Diabetes mellitus – the emphasis must be on treatment and management to avoid complications. Please use this section to discuss how you carefully control and manage your Diabetes. Please let us know what is and isn’t working for you. Feel free to discuss all areas of treatment and management of Diabetes including diet, exercise, weight loss, insulin usage, oral drugs and more.


Like Tree37Likes

Insulin injection versus beta-cell stimulating drugs


Closed Thread
 
Shared Thread Thread Tools
Old 05-02-2012, 11:41   #1
Senior Member
 
policebox's Avatar
 
Join Date: Apr 2012
Location: New Mexico, USA
Posts: 119

Member Type
Type LADA
Diagnosed in 2011

36 likes received
8 likes given
Default Insulin injection versus beta-cell stimulating drugs

Im interested to hear your opinions about using drugs to stimulate pancreatic production of insulin versus insulin injection therapy.

The group of drugs used to stimulate the pancreas into producing more endogenous insulin is called secretagogues and in part include: sulfonylureas (Amaryl, Glucotrol), meglitinides (Prandin); GLP agonists (Byetta, Victoza); DDP-4 inhibitors (Januvia, Tradjenta).

Setting aside other factors, such as cost or side-effects unrelated to this topic of discussion, where do you weigh in on the controversy of secretagogues causing ones already distressed pancreatic beta-cells to burn out faster due to continuous stimulation to produce insulin?

On the other hand, where do you weigh in on the controversy as to whether injection of exogenous insulin takes pressure off ones already distressed pancreatic beta-cells and extends their lives?

Although all discussion is welcomed and appreciated, Im particularly interested in in hearing what your healthcare providers have recommended and any reasoning they may have given for their recommendations (or whether or not this subject was even addressed by your provider). Its not required, but if you have sources to any research articles or websites that you used to help form your opinion, Id appreciate you including them.

policebox is offline  
Old 05-02-2012, 12:41   #2
MCS
WHAT, I got D
 
Join Date: Jul 2010
Location: HOTSVILLE USA
Posts: 3,849

Member Type
Type 2
Diagnosed in 1565

3991 likes received
5218 likes given
Default

I am my own health care provider. I fully believe my over active production of insulin prior to being Dxed is what caused the inflammation in my arteries and prompted me to have a quadruple by-pass. So to answer your question from my prospective, neither one. If I can maintain normal BG's thru diet alone thats the road I'm taking. Sometime in the future if needed I will use insulin while still maintaining my LCHF diet, so as to minimize its use.

Shanny, foxl, Patdart and 2 others like this.
__________________
Control is with Diet modification, exercise, supps.
A1C, Dxed 11, 5.6, 4.8, 4.6
MCS is offline  
Old 05-02-2012, 12:51   #3
Senior Member
 
Join Date: Jun 2009
Location: North East Ohio, USA
Posts: 4,368

Member Type
Type 2
Diagnosed in 2007

1790 likes received
1507 likes given
Default

My doctor has me on Metformin since it has the least side effects. When paired with a Low Carb Diet and exercise it works very well for me. I recently read a study that many doctors now are backing away from sulfyonyureas because of the hypos they cause, not the beta cell burnout. I have seen lots of different diabetics on all sorts of meds and insulin regimens. I am not sure taking insulin before you need it, actually improves your outcome. Many of us still produce insulin we need to eat in ways that preserve that insulin. Many people have told me if I only used insulin then I could eat all those forbidden carbs. Well, I am pretty happy with a LC diet and will stay with it as a managment tool. Now , I would like to be able to consume carbs once in awhile on vacations, but that is another story.

Shanny and VeeJay like this.
__________________
diagnosed Feb 2007
metformin-2550
low carb organic diet
3 T of Coconut Oil daily
moderate exercise- mostly walking 3-5 miles, tennis - 4 hours per week, weight training, hiking on weekends and vacations 7-10 miles

HbA1c 5.3 3/11
HbA1c 6.1 5/12

Age 62
jwags is offline  
 
Old 05-02-2012, 13:02   #4
Moderator
 
VeeJay's Avatar
 
Join Date: Jan 2012
Location: Midwest USA
Posts: 9,412

Member Type
Type 2
Diagnosed in 2010

11981 likes received
4451 likes given
Default

I manage my own diabetes. I have not discussed drugs other than metformin with my doctor - in order to say that I will not take it unless it's really needed. And so far it's not.

To address the insulin stimulating drugs issue. I have read on the forum the experiences of others who have a problem with going hypo with these drugs. My opinion is that one should preserve as much as possible their own insulin production. If the reason for taking these drus is to increase carb consumption, then that's a poor reason, and an unhealthy one.

I don't know why some doctors prescribe them as a matter of course, and others don't. Could be how persuasive the pharma reps are in his local. Surely it can't be because they've done their own research and conclude that this is a good route to take their diabetic patients on. But, then we all know that most diabetics are not much interested in changing they way they eat.

Regarding taking insulin instead of these drugs, my opinion is that the insulin would be the better choice. I would look at it as a supplement to my own (low) insulin production, thereby perserving as many beta cells as possible for as long as possible.

Shanny, MCS and skb like this.
__________________
My low-carb recipe collection on Pinterest
https://www.pinterest.com/VRStudio1/...light-recipes/
70 yrs. Dx May 2010
Diet controlled: VLC/HF
BG steady with no highs or lows.
A1C in the 5% range.
____________________________________
Gluten intolerant, sensitive to dairy & eggs.
Eat no grains

Last edited by VeeJay; 05-02-2012 at 13:06.
VeeJay is offline  
Old 05-02-2012, 13:42   #5
Active Member
 
Join Date: Jan 2012
Location: nepal
Posts: 43

Member Type
Type 2
Diagnosed in 2011

10 likes received
31 likes given
Default

when i was dx type 2 , my first doc told me to go on insulin then i visited 2 more doctors all of their answers were insulin. but i insisted to stay on oral drugs. after 6 months of oral drugs and LCHF my BG were well controlled but this time i insisted my doc to put me on insulin because there were bone and skin left on my body, i looked so ugly .
after 15 days of insulin some of my friends have started telling me i look little better than before.

rudeboysti likes this.
uttam is offline  
Old 05-02-2012, 14:55   #6
Senior Member
 
Join Date: Dec 2009
Posts: 24,394

Member Type
Type 2
Diagnosed in 2009

23930 likes received
32255 likes given
Default

I manage with LCHF and metformin. I will not be found using any drug that hammers my ailing pancreas for more insulin. If the time comes when adjustments to my way-of-eating no longer control my blood glucose, I will move on to insulin.




foxl, MCS, Daytona and 2 others like this.
Shanny is offline  
Old 05-02-2012, 15:06   #7
Senior Member
 
Join Date: Mar 2010
Location: MA, USA
Posts: 1,491

Member Type
Type 2
Diagnosed in 1986

908 likes received
948 likes given
Default

As to your question

My endo acknowledged that there is a question as to weather pills will burn out the pancreas sooner, he did not know the answer.

He did say that he likes insulin better, but most people wont do insulin until after they have to.

__________________
I am not a doctor this is what works for me
You results may differ

Last edited by diabetes86; 05-02-2012 at 15:10.
diabetes86 is offline  
Old 05-02-2012, 15:09   #8
Senior Member
 
policebox's Avatar
 
Join Date: Apr 2012
Location: New Mexico, USA
Posts: 119

Member Type
Type LADA
Diagnosed in 2011

36 likes received
8 likes given
Default

Quote:
Originally Posted by Shanny View Post
I manage with LCHF and metformin. I will not be found using any drug that hammers my ailing pancreas for more insulin. If the time comes when adjustments to my way-of-eating no longer control my blood glucose, I will move on to insulin.
I've heard conflicting opinions about the diagnosis of my DM, the doctor I trust in the most believes I am a late onset type I. Although I was able to manage my impaired fasting blood glucose for a few years through diet and exercise, last year it ultimately developed into DM.

She diagnosed me with DM T1 and we discussed my treatment options. She felt beginning basal insulin therapy would be the better option, but left the avenue of oral drug therapy open if I wanted to avoid insulin therapy, adding that she felt oral drug therapy would probably, at most, only postpone my need for insulin by a few years.

I opted to try oral drug therapy and did so for about a month. Although I had a modest improvement with my blood sugar, I was not seeing the results I wanted fast enough, especially since I did a lot of reading about DM during that month and was eager to prevent future complications of diabetes.

Although I never experienced any side effects, from what I read during my research convinced me that taking a sulfonylurea did not sound like a particularly good solution. Your sentiments agree with my doctor's opinion. Overtaxing an already struggling pancreas did not seem logical, especially since the only serious downside I saw to insulin therapy was taking an injection. But I rationalized it was silly to deny myself a superior treatment option, simply because of fear or the lesser convenience of taking a pill.

After you’ve injected yourself for first time and notice finger-stick tests are more painful than the average injection, it becomes no big deal. In fact, it's fun to whip out a needle and jab yourself in the stomach (okay that part isn't fun)... what I mean is when you do it in front of your squeamish friends and they react as if you are some sort of super human.

policebox is offline  
Old 05-02-2012, 15:45   #9
Moderator
 
moon's Avatar
 
Join Date: Feb 2011
Posts: 6,155

Member Type
Type 2
Diagnosed in 2011

5832 likes received
3463 likes given
Default

I was on glipizide for a short time because my numbers were very high and needed to come down. It was at urgent care that they prescribed it, and when I saw an endocrinologist, he said it was fine for the very short term, but he wanted me off it for the very reason we've discussed. I was able to drop it after about a month, but it did do its short-term job. Had I not been able to maintain control via diet and metformin, I would've gone to insulin.

__________________
Dx'ed Feb 2011 w/ BS > 600
A1C: . . . . . . . . . . . . . . . Other Stuff
2/13/11 .. 14.7 . . . . . . Trig/HDL ratio .. 5.5 to 2.2 in 6 mo
5/23/11 .. 6.2 . . . . . . . Low-carb/high healthy-fat diet
9/8/11 .... 5.6 . . . . . . . No meds, No statin
2/24/16 .... basal/bolus insulin 2-3 days/wk due to steroids

moon is offline  
Old 05-02-2012, 15:55   #10
Senior Member
 
PowerPumper's Avatar
 
Join Date: Aug 2010
Location: Canada
Posts: 156

Member Type
Type 1
Diagnosed in 1975

187 likes received
96 likes given
Default

It's not an easy question to answer and may depend on the patient.

On one hand, insulin injections will give the pancreas a break, but on the other hand, injecting insulin is notoriously inefficient. The chances of promoting insulin resistance and weight gain -- conditions we are trying to fight -- increase.

My recipe is a very LCHF diet, a small basal and maybe even bolus suppliment, metformin, and Victoza. I'd watch very frequently and lower as needed insulin first followed by victoza then metformin last.

*John is not a doctor. Don't trust anything he says!

Shanny and foxl like this.
__________________
"Thoughtcrime does not entail death: thoughtcrime is death." - George Orwell
PowerPumper is offline  
Closed Thread

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Any one switch back from pump therapy to insulin injection? sophie2011 Diabetes Treatment 4 01-08-2012 21:05
Variations in Pre-Meal Insulin Injection Times righteousdude2 Diabetes Forum Lounge 2 02-01-2011 15:19
Burning and itching at insulin injection sites. onaughmae Diabetes Medication and Supplies 6 11-18-2010 16:21
The Beta cell. Anthill Diabetes Forum Lounge 1 12-13-2008 02:19
hypertension versus diabetes krishanlalgupta New Member Introductions 5 11-29-2008 11:05

LEGAL NOTICE
By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.


All times are GMT +1. The time now is 04:55.




Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.