Metformin: does it finally stop working for most people?

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Metformin: does it finally stop working for most people?

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Old 10-04-2010, 22:46   #1
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Default Metformin: does it finally stop working for most people?

Metformin: does it finally stop working for most people?

in that i am now using using 4 500mg Metformin per day i would like to know if it's effects last forever or does it fade away like most medications.

does using twice as much make it twice as effective?



ColaJim, Age 73
Type 2 (very advanced Metabolic Syndrome ) for about 15 years but "insulin/oxygen resistant" for about 40 years
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Old 10-05-2010, 00:19   #2
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My metformin hasn't failed me yet, but I've been on it only 18 months. Pam has been on it for many years, if I'm not mistaken, and still trusts it.

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Old 10-05-2010, 11:21   #3
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I'm hoping that it will stop working for me soon. Why? Because I'm hoping to get off it altogether. I've been down from 2000mg to 1000mg per day for the last three months with hardly any difference in HbA1c - up only from 5.0% to 5.3%. I don't even know whether that slight change was due to the reduction in metformin or to something else.

I've got an appointment with my doctor next Monday to review the situation. I'm hoping that he'll agree to a further reduction or - better still - a trial period with no metformin at all.

Diet is the way to go for me!

Type 2 Diag'd Nov. 2000 - Then A1c 5.7%, TC 7.0, BP 164/109.

A1c following NHS advice: 5.7 > 6.7 > 7.4 > 8.2 > 9.4 > 7.2 > 6.7 > 8.5%

A1c by self-management: 8.5 - 6.8 > 5.7 > 5.5 > 5.3 > 5.3 > 5.1 > 5.0 > 5.3 > 5.5%

TC 4.1 (159)
TG 0.84 (74)
HDL 1.44 (56)
LDL 2.3 (89)

Metformin 2000mg > 1000mg > NIL
Simvastatin 40mg > 20mg > 10mg;
Ramipril 1.25mg;
Bisoprolol 5mg > 2.5mg > 1.25mg;
Aspirin 75mg.

BP now averages around 120/70

Weight Loss: 118kg to 90kg
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Old 10-05-2010, 11:31   #4
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Originally Posted by Shanny View Post
My metformin hasn't failed me yet, but I've been on it only 18 months. Pam has been on it for many years, if I'm not mistaken, and still trusts it.
Yes actually, I have been taking it since sometime in the late 80's. At times I forget to take my evening dose when I really busy with work and school...if I go a few days with only taking half of my daily dose I can see the difference.

Type 2 since age 16
A1c in March 2010 12.6%
current A1c 6.3%

Currently taking:

Metformin 1000mg twice a day
Neurontin 300mg three times a day
Cymbalta 30mg a day
Symlin injections 60 mcg before meals
pumping with the minimed Revel and novalog
Milk Thistle twice a day
Fish oil twice a day
Nexium once a day
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Old 10-05-2010, 14:53   #5
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I've been taking Metformin since 2003 and last year I asked my doctor if I could stop it - just to see if stopping it made any difference in my blood sugar. The first two weeks without it didn't seem to make any difference...but..come the third week my blood sugars started to climb way beyond my target. By the 4th week I really noticed a difference. So I talked with my doctor again and we both decided that even though I thought it didn't make any positive contributions to my overall blood sugar targets, it was in fact helping out after all. I think Metformin's performance varies with each individual person.

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