type 1 & type 2 cause question

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type 1 & type 2 cause question


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Old 08-29-2014, 00:19   #1
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"A new study has found that both type-1 diabetes and type-2 diabetes are the result of the same mechanism - the formation of toxic clumps of a hormone called amylin."

I found this article interesting and wondered if anyone else had heard of this. As in one of the comments below the article said, there's no mention of the immune situation with Type 1s mentioned, so I wonder how accurate this article is.

Type 1 And 2 Diabetes Caused By Same Amylin Hormone Mechanism

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Old 08-29-2014, 01:02   #2
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I'm always wary of such studies because the emphasis is on finding a drug to stop the clumping. It may be the amylin is clumping for a reason and it's protective, rather than the cause of the disease.

Just like statins-- maybe we have higher cholesterol to protect our bodies, and reducing cholesterol is akin to blaming the firefighters who respond to a fire. Attempts to stop beta amyloid plaque in Alzheimer's Disease has been a disaster.

I think the first step to "do no harm" is to make sure there's a good understanding of cause before treating symptoms.
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Old 08-29-2014, 11:47   #3
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I agree entirely. The other issue I have is the ready use of the word 'cause' when all that has been identified is an association.

Something happens - in this case 'the formation of toxic clumps...' . Are these clumps a cause or merely something that happens as well as, or as a result of the development.....

And the mindset is all too often 'can I develop a pill to make a profit....' rather than the true Hippocratic idea of 'do no harm'.

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Old 08-29-2014, 12:18   #4
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Since I believe Diabetes is a symptom with myriad causes, I dis-trust any study that reports an common underlying 'cause'. I tend to think - in the rush to produce a pill, a 'cure' - science is getting cause and effect confused again. We seem to be very, very good at that.

I started researching this one a few days ago. Did not get very far (packing to move house seems to take a lot of time). It sounds to me like the role amylin plays in some diabetes causes may be significant, but is still in process of being understood (links below).

Let's just say I will watch with interest, but I am not planning to be an early adapter.

Can Amylin Analogue Lead To Better Diabetes Control?


Amylin Agonists: A Novel Approach in the Treatment of Diabetes

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Old 08-29-2014, 13:11   #5
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Not actually new, Wiki references date back to 2005 and 2006 in the clinical significance section that discusses the amyloid formation.

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Old 08-29-2014, 14:59   #6
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'Correlation does not imply causation'.




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Old 08-29-2014, 15:15   #7
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I meant to link the Wiki article

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Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (02/2020)
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Old 08-29-2014, 15:19   #8
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I absolutely believe diabetes (1 and 2) have a single cause. But, I also believe they missed it. They are looking at one of the secondary effects, not the beginning of the chain of events.

Diabetic cells lose their ability to clean up the toxins which naturally result from processing glucose for energy. These compounds (methylglyoxal is the most famous and probably the most important) then cause various events in a cascade which is diabetes. Where and in which cells this occurs or occurs most determines the type and nature of diabetes.

This amylin clumping itself is caused by these toxins. This doesn't rule out the immune facet of T1. It is reasonable that once cells become toxified to a certain extent that this could trigger the immune reaction.

Can I (or others) prove it? No, but mark my words and stay tuned!

Anyway, assuming this is right, what's the solution? Process a LOT less glucose.

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Old 08-29-2014, 16:01   #9
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Quote:
Originally Posted by smorgan View Post
what's the solution? Process a LOT less glucose.
ie: a low carb moderate protein high fat diet.

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