do statins increase BG in women?

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do statins increase BG in women?


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Old 12-18-2014, 01:21   #1
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Default do statins increase BG in women?

I'm trying to find info on whether the increased risk for (new) diabetes in women that's associated with taking statins (apparently due to decreasing sensitivity to insulin, maybe other factors) also might mean that statins might, in those already diabetic, actually increase BG. Haven't tracked anything down yet, thought I'd ask here.

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6/28/2012: 500 mg metformin. labs: FBG = 212, A1c = 9.2. weight: 174
7/7/2012: started 2000 mg metformin XR & LC/HF diet
9/28/2012 labs: FBG = 144, A1c=7.5. weight = 160; 12/1/2012 MN 1-mo FBG 103, 2-hr post = 128 // weight = 152 lb
12/30/2012 FBG 1-mo MN =97; 2 hr post MN=121;
1/2/2013: A1c = 6.5 11/2013 A1C=6.6 weight = 147 lb
4/2014 A1C=6.5 weight = 150 lb. 12/2014 A1C=6.5 weight = 147 lb.
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Old 12-18-2014, 01:33   #2
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I took a statin during the first year I was diagnosed, and those were the lowest levels I've ever had. My total bg average was 110 mg/dl. I was in the hospital for cataract surgery at that time, and had to suspend my metformin for a few days, and the nurses taking my readings all exclaimed that those 130s were GOOD! My response was that they were NOT good - my freakin' overall average was 110! I've never been able to regain the ground I lost then either, but if statins are what helped it, then it just is what it is - I will never EVER take statins again.




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Old 12-18-2014, 01:44   #3
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Here's a recent study abstract showing the mechanism by which statins impair glucose uptake in human cells Statins impair glucose uptake in human cells. - PubMed - NCBI

and here's one showing increase in fasting BG of ~40 mg/dL in diabetics, far higher than the rise in non-diabetics Statins impair glucose uptake in human cells. - PubMed - NCBI

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Type II since ~2008. Ignored reality until 2012.

6/28/2012: 500 mg metformin. labs: FBG = 212, A1c = 9.2. weight: 174
7/7/2012: started 2000 mg metformin XR & LC/HF diet
9/28/2012 labs: FBG = 144, A1c=7.5. weight = 160; 12/1/2012 MN 1-mo FBG 103, 2-hr post = 128 // weight = 152 lb
12/30/2012 FBG 1-mo MN =97; 2 hr post MN=121;
1/2/2013: A1c = 6.5 11/2013 A1C=6.6 weight = 147 lb
4/2014 A1C=6.5 weight = 150 lb. 12/2014 A1C=6.5 weight = 147 lb.
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Old 12-18-2014, 01:50   #4
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Is this something like what you were asking about?

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Old 12-18-2014, 01:54   #5
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Or this. I knew Lipitor was guilty as charged, not sure about others.

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Old 12-18-2014, 02:03   #6
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thanks. useful info. I'm especially curious about effects in women because (a) I am one and (b) apparently men didn't show the same increased risk for new-onset of diabetes after taking statins. That suggests, possibly, a greater problematic effect of statins on BG regulation in diabetic women than men. I've been searching PubMed but haven't yet found anything specifically on differential effects of statins (especially lipitor) with gender. My guess is that studies are in the works. However, the several articles on general increase in FBG & HbA1c are reason enough for avoiding statins in my mind.

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Type II since ~2008. Ignored reality until 2012.

6/28/2012: 500 mg metformin. labs: FBG = 212, A1c = 9.2. weight: 174
7/7/2012: started 2000 mg metformin XR & LC/HF diet
9/28/2012 labs: FBG = 144, A1c=7.5. weight = 160; 12/1/2012 MN 1-mo FBG 103, 2-hr post = 128 // weight = 152 lb
12/30/2012 FBG 1-mo MN =97; 2 hr post MN=121;
1/2/2013: A1c = 6.5 11/2013 A1C=6.6 weight = 147 lb
4/2014 A1C=6.5 weight = 150 lb. 12/2014 A1C=6.5 weight = 147 lb.

Last edited by 4thcorner; 12-18-2014 at 02:04. Reason: typo
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Old 12-18-2014, 02:27   #7
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All else I can say is that BH has been on atorvastatin since his MI two years ago, and his fasting glucose is creeping up - and it topped 100 on his last labs a few weeks ago.




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Old 12-18-2014, 04:57   #8
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Yes, I thought I'd bookmarked the studies but they are not at hand. Here's one though: http://www.ncbi.nlm.nih.gov/m/pubmed/22231607/

In addition, there is NOT ONE study showing statins are effective as primary prevention in women when you look at actual risk.

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Last edited by Janknitz; 12-18-2014 at 05:03.
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Old 12-20-2014, 18:47   #9
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Here's the correct 2nd citation (I mistakenly repeated the same article link in post #3) to an article showing considerable average increase (~40 pts) in fasting plasma glucose in male diabetics taking statins. Too bad the abstract lacks info on type of statin, diabetic A1c etc. And no women were included :-(

Effect of statins on fasting plasma glucose in diabetic and nondiab... - PubMed - NCBI

__________________
Type II since ~2008. Ignored reality until 2012.

6/28/2012: 500 mg metformin. labs: FBG = 212, A1c = 9.2. weight: 174
7/7/2012: started 2000 mg metformin XR & LC/HF diet
9/28/2012 labs: FBG = 144, A1c=7.5. weight = 160; 12/1/2012 MN 1-mo FBG 103, 2-hr post = 128 // weight = 152 lb
12/30/2012 FBG 1-mo MN =97; 2 hr post MN=121;
1/2/2013: A1c = 6.5 11/2013 A1C=6.6 weight = 147 lb
4/2014 A1C=6.5 weight = 150 lb. 12/2014 A1C=6.5 weight = 147 lb.

Last edited by 4thcorner; 12-20-2014 at 18:52. Reason: typo
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Old 12-21-2014, 01:49   #10
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Quote:
Originally Posted by 4thcorner View Post
Here's the correct 2nd citation (I mistakenly repeated the same article link in post #3) to an article showing considerable average increase (~40 pts) in fasting plasma glucose in male diabetics taking statins. Too bad the abstract lacks info on type of statin, diabetic A1c etc. And no women were included :-(

Effect of statins on fasting plasma glucose in diabetic and nondiab... - PubMed - NCBI
Why would anyone take a statin?

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