"How fatty diets cause diabetes"

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"How fatty diets cause diabetes"


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Old 08-15-2011, 01:11   #1
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"High levels of fat shut down a key enzyme that promotes glucose sensing in pancreatic beta cells -- revealing a pathway implicated in the type 2 diabetes epidemic". Interesting article.

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Old 08-15-2011, 01:18   #2
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This has certainly taken the cyber-medics by storm - nearly 3000 hits on Google already today! What are your thoughts, Rad?




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Old 08-15-2011, 01:35   #3
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Quote:
Originally Posted by Shanny View Post
This has certainly taken the cyber-medics by storm - nearly 3000 hits on Google already today! What are your thoughts, Rad?
Shanny, I have to admit that I am not strong in biochemistry, microbiology, or plain old biology. I am just awaiting more analysis from better informed people. Personally, I do not prefer high fat diets - moderation in everything is what I strive for. But what is moderate for me can be high or low for another person :-)

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Old 08-15-2011, 01:43   #4
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Interesting read... but they don't define the type of high-fat diet... if it's the standard american diet - it's high in carbs and fat, processed foods, hydrogenated oil, high fructose corn syrup, etc. There is no indication of the type of fat or diet.

It is known that excess fat (in the body, not digested) impairs glucose sensitivity, so that is something else to consider.

Feeding mice a high fat diet - what kind of fat and did it make the mice obese?

However, if they can figure out how to preserve the GnT-4a function, that might be a step in the right direction.

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Old 08-15-2011, 02:19   #5
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Quote:
Originally Posted by Rad Warrier View Post
Personally, I do not prefer high fat diets -
I was talking about this with a friend last night. I said if diabetes wasn't an issue, and I could feel good on any diet I chose - I would gleefully flee back to my carbs of fruit, grains, crusty breads, but ... I'd like to keep a bit of my new-found bacon for flavoring

This isn't a whine, honest, but I do get tired of fat - the mouth-feel if nothing else. I need more variety in my diet to keep me from burning out. Before, I could eat risotto and fruit happily every day if need be.

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Old 08-15-2011, 02:59   #6
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moon:

Well, if that is how you feel about your diet, maybe you should check out an insulin basal/bolus system so you would have more liberty to eat a more varied diet. Insulin does give a lot more freedom to choose.

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Quote:
Originally Posted by moon View Post
I was talking about this with a friend last night. I said if diabetes wasn't an issue, and I could feel good on any diet I chose - I would gleefully flee back to my carbs of fruit, grains, crusty breads, but ... I'd like to keep a bit of my new-found bacon for flavoring

This isn't a whine, honest, but I do get tired of fat - the mouth-feel if nothing else. I need more variety in my diet to keep me from burning out. Before, I could eat risotto and fruit happily every day if need be.

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Old 08-15-2011, 06:08   #7
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Well, if that is how you feel about your diet, maybe you should check out an insulin basal/bolus system so you would have more liberty to eat a more varied diet. Insulin does give a lot more freedom to choose.
Thanks Jim - valid suggestion. When I said needing more variety, I meant I have to vary my meals a lot more, constantly cook new/different things, because I get tired of the same thing a lot quicker.

I'm actually thinking of going in the opposite direction at some point this year - cutting back on metformin once my exercise has stepped up, weight more down, carbs more down - just to see. I'd be stoked if I could back down to 1000 mg metformin since I'm still not in the gastric clear with it. If not, I'll live w/ it.

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2/13/11 .. 14.7 . . . . . . Trig/HDL ratio .. 5.5 to 2.2 in 6 mo
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Old 08-15-2011, 11:32   #8
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Here is an abstract of the published article (US $32 for full access) Nature Medicine - Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

Eye-catching headline and they do (so far as I can tell) establish a connection between free fatty acids in the blood and "metabolic disease, including hyperglycemia, impaired glucose tolerance, hyperinsulinemia, hepatic steatosis and diminished insulin action in muscle and adipose tissues" BUT where is the connection between what we eat and "elevated levels of free fatty acids"?

As above my money is on the increased consumption of refined carbohydrates (possibly in large part fructose) in the diet as the cause of increased FFAs in the blood stream. It's high time we got past this simplistic idea that what we eat goes unaltered into our blood stream.

The USDA guidelines have made a significant impact... the statistics show people are eating less fat, so why is the problem just getting worse?

---

If you are looking for a critique of the article I'd point out it starts off with...
Quote:
Newly diagnosed type 2 diabetics tend to have one thing in common: obesity.
which we know is not true in around 20% of cases so that puts a big fat hole in their follow-up assumptions.


Soon after it says...
Quote:
"The identification of the molecular players in this pathway to diabetes suggests new therapeutic targets and approaches towards developing an effective preventative or perhaps curative treatment," Dr. Marth continued. "This may be accomplished by beta cell gene therapy or by drugs that interfere with this pathway in order to maintain normal beta cell function."
If diet is the cause, then why no mention of a dietary intervention? Jump straight to something patentable and profitable?


I'd like to know what they were feeding these mice thanks.

As for "high fat" I agree with you Rad.. it is a relative term and I think the way I eat is moderate and well balanced... much like my Grandparents ate... it is only seen as "high fat" when compared to the recent fat-phobic dogma. And by every health marker my Doctor tests, I am better of than I was when following the standard dietary guidelines.

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Old 08-15-2011, 14:06   #9
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I do think the type of fat makes a big difference. I avoided all fats for years before diabetes. I didn't eat meat, cheese, butter, etc. The only fats I ate were from vegetable oils. Of course I still got diabetes. Now I eat natural real fats and restrict my carbs. My bgs behave a lot better. I think our government has pushed us for years into avoiding fats and I do think that is the problem. The problem with research is how do you separate the fats people are eating from the higher carb diet that everyone eats. Ever since I had kids 32 years ago I carrried an extra small amount of weight. Of course most of it was in my belly. I now feel eating the wrong type of fats ( canola oil, vegetable oil, margerines and fake fats) attributed to it. Many of these oils oxidize when heated causing free radicals which promote disease. Going back to real fats ( butter, bacon fat, real dairy and coconut oil) has let me lose so much weight and become healthier.

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Old 08-15-2011, 14:47   #10
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It has been mentioned elsewhere this study was done in mice. Mice are herbivores, and a high-fat diet is not what they evolved to consume. Most of the species used in research were bred from animals evolved to consume grains.

Now, that may sound lame, we have heard this argument before.

But I happen to know that cats (obligate carnivores) who cease to eat for any reason for 24- 48 hours, are at risk to develop a fatty liver condition known as hepatic lipidosis. Yes, fatty liver. And it can kill them, fast. Is that different from how humans react in starvation? Yes, probably. And yet in the general scheme of things, cats' genes, and metabolism, are far closer to our own.

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