New research on pancreas burnout by oral meds?

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New research on pancreas burnout by oral meds?


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Old 04-02-2016, 04:03   #1
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Default New research on pancreas burnout by oral meds?

I have seen differing opinions on whether oral meds like glyburide etc decrease the life of beta cells, leading to pancreas burnout. I have asked top researchers and gotten various answers.

Does anyone know of any recent research on this issue?

Thank you

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Old 04-02-2016, 15:55   #2
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Here is a look at the incretin drugs (which force your pancreas to produce more insulin) from Blood Sugar 101. and here's her latest update based on more recent research.

Personally, after I read about these types of drugs, I stopped taking Glipizide and decided to stick to Metformin and insulin. The side effects are well known, they work, and you can adjust the dose based on your needs.

Are you currently taking one of these drugs? How is that working for you?

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Old 04-02-2016, 17:11   #3
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Originally Posted by Daytona View Post
Here is a look at the incretin drugs (which force your pancreas to produce more insulin) from Blood Sugar 101. and here's her latest update based on more recent research.

Personally, after I read about these types of drugs, I stopped taking Glipizide and decided to stick to Metformin and insulin. The side effects are well known, they work, and you can adjust the dose based on your needs.

Are you currently taking one of these drugs? How is that working for you?
Thank you for your comment. My BS are always under 6.1, for 20 years. Last a1c was 5.7. Now on 1 mg glimepiride and 2500 metformin, so control is good. No side effects. I want to have some beta cells if they are later needed for some cure some day. Age 68 now. Trying to come off the glimepride with more weight loss/exercise. Don't know if it is pathway damage or decrease in betas. Last c peptide showed still producing. I try to follow folks like Dr. Larry Distiller, researchgate.net etc, but there is no definitive answer yet it seems.

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Old 04-02-2016, 17:37   #4
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Daytona, it seems that you are confusing two different types of drugs. Your links are for the GLP-1 Agonist type of drugs while Glyburide is a sulfonylurea. I took a sulfonylurea called Glipizide for several years and it was possible for me to get off of it entirely by changing to LCHF. Jenny Ruhl used to state that sulfonylureas were tee cause for killing beta cells but in her more recent book she said that the newer research caused her to change that view. The biggest cause of damage to beta cells is high blood sugar. In my opinion it is extremely hard to control blood sugar by using any type of drug. There is no way to regulate the dose of each time you take it and the idea that you can just take two pills a day and cover highs and lows just doesn't work. This is why the ADA wants PWD to consume higher levels of carbs for each meal and snacks in between. Even though my A1c was in the 6% range I knew that meals could raise my bg to over 300 but my doctors just ignored that and as long as my A1c was under 7% I was considered " doing just fine". It's been 2 1/2 years since I started LCHF and, for me at least, it has been much easier to keep my bg much more consistent and lower than it ever was trying to use a drug. I didn't mean to start a lecture, I just thought people should know that using any kind of drug to control bg, even insulin, is difficult and in many cases impossible. Check with anyone using insulin and you will see how much work it is to maintain even blood sugar levels, even though they can vary the dosage and inject at any time..
I probably didn't answer the question, the bottom line is that whether the drug does or doesn't cause beta cell destruction, resulting high blood sugar most certainly will and I am an example of that. It didn't happen over night as I took it for many years but it did happen and I have lost a lot of my ability to produce insulin and therefore have to rely on a very carb restrictive diet to control by bg but it is possible. I just wish that I learned this a few years ago.

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Old 04-02-2016, 22:12   #5
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I wasn't sure if he was asking about Glyburide specifically, or just incretin drugs in general. My opinion on them doesn't change much regardless of the subset (GLP-1's) vs another (sulfonylurea's).

If you are interested in more research on Glyburide, here's another article: Amaryl, Glyburide, Prandin, Starlix: Drugs that Stimulate Insulin Secretion.

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Old 04-03-2016, 02:48   #6
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I agree Dayna, I don't like using either one either. I wasn't trying to be critical but just wanted to clarify that when he asked about Glyburide he was asking about a sulfonylurea not a GLP-1 Agonist. Both are not very useful in my opinion but the sulfonylurea has been around for a lot of years and there have been many times that it has been speculated that they destroy beta cells.
GLP-1 Agonist have been available for a much shorter time and Doctors are apparently rushing to prescribe them to their patients.
Like we have said many times here diet and exercise, to a small extent go much further in doing a good job of controlling bg.

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