Metformin ER/MR vs Metformin

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Metformin ER/MR vs Metformin

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Old 03-31-2012, 12:58   #1
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Question Metformin ER/MR vs Metformin

Hi guys,

Couple of questions on behalf of my mother... And please forgive me if this is in the wrong forum (or community altogether!)

6 months or so ago, she was diagnosed with type-2 diabetes and has since been taking Metformin 500g x2 per day (one in the morning and one just after dinner in the evenings at about 19.30).

She's found herself waking up to urinate several times in the middle of the night since being prescribed the Metformin and wants to know if this is a common/expected effect of taking this?

As a result, research and some recommendations suggest she might see better results with either Metformin Extended Release or Metformin Modified Release.

Appreciate all your help guys!

Thanks in advance,


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Old 03-31-2012, 13:36   #2
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Hi Mike - welcome to the forum.

I'm not aware of frequent urination being a side effect of metformin. What is typical is gastric side effects. The extended release does curb that for many.

You don't say what her blood sugar is. If she's running high, the frequent urination could be a result of that. Or, it could be unrelated (eg UTI) and coincidental with the start of metformin.

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Dx'ed Feb 2011 w/ BS > 600
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Old 03-31-2012, 14:12   #3
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Usually frequent urination is due to very high bgs. Metformin works in the liver not the pancreas. So it works by limiting our liver's conversion of glycogen into availble glucose. It really doesn't work at meal time. The different between the regular and the ER is that the ER is time released and is gentler on the stomach. I take the maximum amount of the regular which is 2550. I often get up once or twice during the night, but I think it is more my age.

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low carb organic diet
3 T of Coconut Oil daily
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Old 03-31-2012, 16:11   #4
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I think this maybe her sugar still being a bit out of bounds. Metformin makes me stomach hurt (a full dosage that is) but I've never had frequent urination on it. Do you have a glucose meter? If so please advise her to use it regularly. The urinating will stop once the sugar levels drop.

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Old 03-31-2012, 23:56   #5
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Was your mother told to drink plenty of water when she was diagnosed? I find that if I don't drink most of my water early in the day, I get very thirsty later in the day, and also get a dehydration headache. If I then drink plenty of water to counteract it, I'll have to get up more during the night. And if I am then thirsty and have a few mouthfuls of water each time I get up, it's almost exactly two hours between waking up times to urinate.

It doesn't bother me, because I know why it's happened, and I also go straight back to sleep afterwards.

Old 04-03-2012, 10:08   #6
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Hi guys,

Thanks for the responses.

I'll advise it could just be a result of increased fluid consumption at night before bed. Sounds logical!!

FYI, are blood tests reported the following:
Lipids 6.4 6.2
HBA1C 50 45
Urea 54
B12 1000
Serum cholesterol 7.3 6..2
Weight 47.3 43
Height 5ft 5ft
BMI 20 18.5

On another note, what is the difference if any between:
- Metformin Sustained Release
- Metformin Extended Release
- Metformin Modified Release (what she has been prescribed)

And what dosage of the MR do you think she should be on? As mentioned previously she is currently on 100mg (500mg x2) of normal Metformin per day, but has just been prescribed Metformin Modified Release (whatever that is!?) at a dosage of 500mg twice a day.

So my question is, why has my Doc prescribed the same dosage for the time-release Metformin as the normal Metformin?

Any ideaS?



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