Interest read on reversing Type 1

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Interest read on reversing Type 1


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Old 06-24-2018, 11:35   #1
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Default Interest read on reversing Type 1

An interesting read on using a generic vaccine that can possibly reverse Type 1 diabetes. See link....
https://www.massgeneral.org/News/pre...e.aspx?id=2262

Wonder if it could possibly work for type 2's?

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Old 06-24-2018, 15:00   #2
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It is mentioned, 5th paragraph from the end of the article.

Wonder why the body doesn't switch glucose metabolism mechanisms automatically?

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Old 06-24-2018, 17:55   #3
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Interesting article.

My summary after reading the article.

Regular monitoring of clinical trial participants found that HbA1c levels of those receiving BCG had dropped by more than 10 percent at three years after treatment and by more than 18 percent at four years and with no reports of severe hypoglycemia

My Response.

Tt is a process of 4 years as well as a gradual one where were were talking 10% and up to 18% reduction in A1c levels. Example would be if someone with A1c of 7.0 after 3 years could attain an A1c of 6.3 and after 4 yrs of 5.7 providing all other factors around glucose control by the type 1 diabetic has not changed such as eating habits, carb consumption, activity level, insulin management , weight, and metabolism. I also focused on the risk of hypoglycemia episodes and saw no reports of severe hypoglycemia which tells me moderate and minor hypoglycemia would still be present.


The 2nd point made is regarding the statement:

BCG has been known for more than 30 years to boost production of a cytokine called tumor necrosis factor (TNF), which may be beneficial in autoimmune diseases both by eliminating the autoreactive T cells that attack an individual’s tissues – in the case of type 1 diabetes, pancreatic islets – and by inducing production of regulatory T cells (Tregs) that could prevent an autoimmune reaction

My question based on the above paragraph is how is increased insulin production accomplished? It says in article that the mechanism at play is a shifting of the process of glucose metabolism from oxidative phosphorylation, the most common pathway by which cells convert glucose into energy, to aerobic glycolysis, a process that involves significantly greater glucose consumption by cells.

Where is the increase of insulin? In type 1 diabetes, beta cells are required to produce insulin. We as type 1 diabetics do not have any or levels far to inadequate to make a difference.


My 3rd point is the statement referred to in article that says:

Reverse advanced type 1 diabetes

I would say this vaccine is more of a glucose management tool to improve glucose control not a reversal of type 1 diabetes.

Being the current BCG vaccine clinical trials are in Phase 2 and the molasses pace and challenges of getting FDA approval to the public with type 1 and possibly type 2, a conservative estimate could be 20+ years.

Wouldnt this vaccine have beneficial aspects for those who have not yet developed type 1 diabetes based on minimizing or eliminating the autoreactive T cells?

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Last edited by Hearts Jounrey; 06-24-2018 at 18:02.
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