Interest read on reversing Type 1

Go Back   The Diabetes Forum Support Community For Diabetics Online > Diabetes Forum Community > Diabetes

Diabetes This section of the forum can be used to discuss anything and everything to do with Diabetes. Please use this general Diabetes section for any comments or discussions that don't fit into the more specific forum categories below. Please also ensure that all posts and threads are on topic, about Diabetes.

Interest read on reversing Type 1

Closed Thread
Shared Thread Thread Tools
Old 06-24-2018, 11:35   #1
Senior Member
Join Date: Sep 2017
Location: Central, NJ USA
Posts: 452

Member Type
Type 2
Diagnosed in 2013

785 likes received
313 likes given
Default Interest read on reversing Type 1

An interesting read on using a generic vaccine that can possibly reverse Type 1 diabetes. See link....

Wonder if it could possibly work for type 2's?


fjk2013 is offline  
Old 06-24-2018, 15:00   #2
mbuster's Avatar
Join Date: Sep 2011
Location: SW Arkansas
Posts: 9,215

Member Type
Type 2
Diagnosed in Feb. 2012

11114 likes received
6369 likes given

It is mentioned, 5th paragraph from the end of the article.

Wonder why the body doesn't switch glucose metabolism mechanisms automatically?

Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (07/2019)
TC 183 LDL 102 HDL 65 TG 52 (02/20/2020)
Supplemental vitamins and electrolytes
64 YY Love the LCHF diet. The cheese goes well with my whine

updated 02//20
mbuster is online now  
Old 06-24-2018, 17:55   #3
Senior Member
Join Date: Apr 2016
Location: California
Posts: 495

Member Type
Type 1
Diagnosed in 1977

381 likes received
10 likes given

Interesting article.

My summary after reading the article.

Regular monitoring of clinical trial participants found that HbA1c levels of those receiving BCG had dropped by more than 10 percent at three years after treatment and by more than 18 percent at four years and with no reports of severe hypoglycemia

My Response.

Tt is a process of 4 years as well as a gradual one where were were talking 10% and up to 18% reduction in A1c levels. Example would be if someone with A1c of 7.0 after 3 years could attain an A1c of 6.3 and after 4 yrs of 5.7 providing all other factors around glucose control by the type 1 diabetic has not changed such as eating habits, carb consumption, activity level, insulin management , weight, and metabolism. I also focused on the risk of hypoglycemia episodes and saw no reports of severe hypoglycemia which tells me moderate and minor hypoglycemia would still be present.

The 2nd point made is regarding the statement:

BCG has been known for more than 30 years to boost production of a cytokine called tumor necrosis factor (TNF), which may be beneficial in autoimmune diseases both by eliminating the autoreactive T cells that attack an individual’s tissues – in the case of type 1 diabetes, pancreatic islets – and by inducing production of regulatory T cells (Tregs) that could prevent an autoimmune reaction

My question based on the above paragraph is how is increased insulin production accomplished? It says in article that the mechanism at play is a shifting of the process of glucose metabolism from oxidative phosphorylation, the most common pathway by which cells convert glucose into energy, to aerobic glycolysis, a process that involves significantly greater glucose consumption by cells.

Where is the increase of insulin? In type 1 diabetes, beta cells are required to produce insulin. We as type 1 diabetics do not have any or levels far to inadequate to make a difference.

My 3rd point is the statement referred to in article that says:

Reverse advanced type 1 diabetes

I would say this vaccine is more of a glucose management tool to improve glucose control not a reversal of type 1 diabetes.

Being the current BCG vaccine clinical trials are in Phase 2 and the molasses pace and challenges of getting FDA approval to the public with type 1 and possibly type 2, a conservative estimate could be 20+ years.

Wouldnt this vaccine have beneficial aspects for those who have not yet developed type 1 diabetes based on minimizing or eliminating the autoreactive T cells?

Diagnosed with Type 1 diabetes Sept 12 1977
Developed Hypoglycemic Unawareness Dec 83
8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
Lost 2 transplanted pancreas; 6/2001 & 6/2015
Longtime advocate & member of diabetes & cancer support forums for 15 yrs. A1c 5.0

Last edited by Hearts Jounrey; 06-24-2018 at 18:02.
Hearts Jounrey is offline  
Closed Thread

bcg vaccine and type 1

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are Off

Similar Threads
Thread Thread Starter Forum Replies Last Post
This Scottish Doctor is careful about conflicts of interest. RobertIA Diabetes Forum Lounge 8 08-13-2014 11:40
No interest in food virginia1954 Diabetes Symptoms 3 07-05-2013 07:22
News Article of interest? Patdart Diabetes Forum Lounge 4 03-12-2012 21:53
Canadian Diabetes Association and Conflicts of Interest... beefy Diabetes News 1 10-29-2011 21:18
Reversing diabetes type 2 is it possible xdiabetic Diabetes News 17 06-20-2011 04:38

By using this Website, you agree to abide by our Terms and Conditions (the "Terms"). This notice does not replace our Terms, which you must read in full as they contain important information. You must not post any defamatory, unlawful or undesirable content, or any content copied from a third party, on the Website. You must not copy material from the Website except in accordance with the Terms. This Website gives users an opportunity to share information only and is not intended to contain any advice which you should rely upon. It does not replace the need to take professional or other advice. We have no liability to you or any other person in respect of any content on this Website.

All times are GMT +1. The time now is 09:48.

Powered by vBulletin®
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Search Engine Optimization by vBSEO
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
User Alert System provided by Advanced User Tagging v3.1.0 (Pro) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.