Insulin Resistance in Type 2.

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Insulin Resistance in Type 2.


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Old 08-18-2018, 21:32   #1
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Default Insulin Resistance in Type 2.

Can insulin resistance in isolation be a sufficient factor to cause diabetes?. OR is the evidence of Impaired β-cell function a necessary defect in conditions of impaired glucose regulation?

As far as i know, i do not believe there is a way thru imaging or biopsy of the beta cells within the islets in the pancreas to assess damage or impairment. I do know secreted inflammatory cytokines can target and damage beta cells as well as and repeated and elevated hyperglycemia (140+). The research i have done shows type 2 diabetes develops in people that are unable to sustain β cell mass as an adequate response to glucose demands.

Below is an excellent and very revealing definition of the relationship between beta cell failure and Type 2 as outlined by the following resource link:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483155/

Quote:
Islet β cell failure and the natural history of T2D.
T2D develops in response to overnutriton and lack of physical activity in subjects that have underlying genetic and acquired predispositions to both insulin resistance (and/or hyperinsulinemia) and β cell dysfunction. Over time, islet β cell compensation for the insulin resistance fails, resulting in a progressive decline in β cell function. As a consequence, subjects progress from normal glucose tolerance (NGT) to IGT and finally to established T2D. Even after diagnosis of T2D, β cell function continues to worsen such that subjects progress from needing changes in diet/exercise only to requiring oral hypoglycemic agents and eventually insulin for achievement of adequate glycemic control. Future therapies will be directed not only to achievement of euglycemia, but also changing the course of the disease by reversing the processes of β cell failure.

__________________
Diagnosed with Type 1 diabetes Sept 12 1977
Developed Hypoglycemic Unawareness Dec 83
8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
Lost 2 transplanted pancreas; 6/2001 & 6/2015
Longtime advocate & member of diabetes & cancer support forums for 15 yrs. A1c 5.0
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Old 08-19-2018, 04:25   #2
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Quote:
Below is an excellent and very revealing definition of the relationship between beta cell failure and Type 2 as outlined by the following resource link:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483155/
Quote:
Islet β cell failure and the natural history of T2D.
T2D develops in response to overnutriton and lack of physical activity in subjects that have underlying genetic and acquired predispositions to both insulin resistance (and/or hyperinsulinemia) and β cell dysfunction. Over time, islet β cell compensation for the insulin resistance fails, resulting in a progressive decline in β cell function. As a consequence, subjects progress from normal glucose tolerance (NGT) to IGT and finally to established T2D. Even after diagnosis of T2D, β cell function continues to worsen such that subjects progress from needing changes in diet/exercise only to requiring oral hypoglycemic agents and eventually insulin for achievement of adequate glycemic control. Future therapies will be directed not only to achievement of euglycemia, but also changing the course of the disease by reversing the processes of β cell failure.
Why wait for the future therapies? Low carb addresses euglycemia now and could possibly prevent beta cell failure. Why isn't euinsulinemia a word?

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Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (02/2020)
TC 183 LDL 102 HDL 65 TG 52 (02/20/2020)
Supplemental vitamins and electrolytes
65 YY Love the LCHF diet. The cheese goes well with my whine

updated 10/12/2020
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Old 08-19-2018, 04:35   #3
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what % of type 2 (30 million ) are on Keto? how many remain committed to it?

__________________
Diagnosed with Type 1 diabetes Sept 12 1977
Developed Hypoglycemic Unawareness Dec 83
8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
Lost 2 transplanted pancreas; 6/2001 & 6/2015
Longtime advocate & member of diabetes & cancer support forums for 15 yrs. A1c 5.0
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Old 08-19-2018, 05:36   #4
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We know one component of IR is from over sized adipose cells and ectopic organ fat such as liver and pancreas. Another is impairment of beta cells. In terms of order, increase of liver fat appears to precede development of T2 in most individuals, whereas muscle insulin resistance appears to be a longer standing.

Ectopic liver fat is the best example of ectopic fat, but more research on pancreatic fat as a potential cause of β-cell dysfunction needs to be more further investigated. This ectopic fat concept broadly fits with the idea that individuals of similar ages can develop diabetes at different body mass indexes. Those with risk factors leading to more rapid ectopic fat gain such as sex, certain ethnicities, and potentially those with a family history of diabetes, as well as others with genes linked to a reduced subcutaneous adiposity are more likely to develop diabetes at a younger age and/or lower BMI than those without.

__________________
Diagnosed with Type 1 diabetes Sept 12 1977
Developed Hypoglycemic Unawareness Dec 83
8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
Lost 2 transplanted pancreas; 6/2001 & 6/2015
Longtime advocate & member of diabetes & cancer support forums for 15 yrs. A1c 5.0
Hearts Jounrey is offline  
Old 08-19-2018, 13:45   #5
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Quote:
Originally Posted by Hearts Jounrey View Post
what % of type 2 (30 million ) are on Keto? how many remain committed to it?
I am not personally aware of whether or not any statistics have been gathered along that line or not. If there is, I have never been polled but can say if they want my n=1 to add to their database, I am and I have.

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__________________
Think I've had this since 2003. Told I was Type 2 lean on 2/13/12.
a1c 8.8 (8/2011) 5.2 (02/2020)
TC 183 LDL 102 HDL 65 TG 52 (02/20/2020)
Supplemental vitamins and electrolytes
65 YY Love the LCHF diet. The cheese goes well with my whine

updated 10/12/2020
mbuster is offline  
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