Son's GAD test results

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Son's GAD test results


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Old 07-28-2018, 21:20   #1
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Default Son's GAD test results

[Moderator edit: This is a duplicate of the post that started the introductory thread Mother needing info.

Given the depth of discussion of testing to determine if Lily B's son has diabetes of any type, it was decided to move the bulk of the testing process discussion here so it can serve as a reference to other forum members who might find this information useful. The introductory thread will be locked; further discussion on this topic should continue here, and @Lily-B is encouraged to start other threads if she seeks additional information/support on diabetes-related topics beyond this diagnosis process.]


Hi I'm new to the forum, my son was diagnosed in April this year
With type 1, he is 30 and slim so he has been classed as type 1.
Son lives away from us so don't get to speak about it

He was unwell one day and mentioned it to his pal who is a doctor
he checked my sons BG it was 17 so he got him in hospital that morning
The hospital gave him a test which said he had small amount of ketones in his blood, because of his age and slim they gave him insulin to take once a day, 10units at bedtime, which by bedtime his BG was 12, then back to 5 the next morning thankfuly.
Within 3 days he was brought of insulin as is BG was to low they said.

Now his BG reading on waking is 3/4
1 1/2 after lunch it's 5.5
1 1/2 after dinner it's 6

He hasn't changed in the last 4 months
His specialist has done a GAD test on him we are awaiting results
she said his average 12weeks BG was normal readings!!

Do you think he could be type 1.5 or 2

Thanks in advance


Last edited by itissteve; 08-22-2018 at 21:54. Reason: Provide background to thread move
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Old 07-29-2018, 15:40   #2
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Determine if son has type 1 or type 1.5 first. GAD antibody test will help determine if he has LADA (1.5) diabetes. Results from one test should not be taken as a definitive diagnosis, instead two tests should be used to corroborate results.

Performing GADA antibody test is the most common method of diagnosing LADA but not all patients have these antibodies. In the very early stages of LADA, it is possible that there are no detectable antibodies, but they can develop over time. Therefore GADA test alone cannot rule out LADA.

LADA is distinguished from type 2 diabetes by the presence of islet autoantibodies that are common to type 1 diabetes.

Patients with type 1 diabetes commonly have 2 or more of 4 islet autoantibodies
these 4 include:

glutamic acid decarboxylase autoantibodies (GAD)
islet cell antigens (ICAs)
tyrosine phosphatase proteins (IA-2s)

Antibodies to (Insulin)

whereas patients with LADA typically only have one autoantibody. LADA patients have far less incidence of IA-2 and ICA autoantibodies than patients with type 1

Other testing for type 1.5 diabetes include having a "c-peptide" blood test to measure insulin production levels. This c-peptide biomarker is becoming more commonly used to distinguish T1.5 and T2. C-peptide is very low in people with T1D, low in people with T1.5 and normal in people with T2D.

In summary, i would have your son get all 4 of the antibody tests mentioned above highlighted in blue and a c-peptide test. If he has no auto-antibodies and his C peptide appear to be normal (fasting and after eating), then type 2 is likely but i would still follow up with periodic testing to see if anything has changed with his antibody or c -peptide levels

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Last edited by Hearts Jounrey; 07-29-2018 at 15:47.
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Old 07-29-2018, 16:01   #3
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I just wanted to translate Blood sugar values listed here from mmol/L to mg/dL that United States uses so its easier to know what value is for many of readers here. Basically multiply mmol value by 18

mmol/l = 5 mg/dl = 90
mmol/l = 6 mg/dl = 108
mmol/l = 12 mg/dl = 216
mmol/l = 17 mg/dl = 305

Quote:
Originally Posted by Lily B View Post
Hi I'm new to the forum, my son was diagnosed in April this year
With type 1, he is 30 and slim so he has been classed as type 1.
Son lives away from us so don't get to speak about it

He was unwell one day and mentioned it to his pal who is a doctor
he checked my sons BG it was 17 so he got him in hospital that morning
The hospital gave him a test which said he had small amount of ketones in his blood, because of his age and slim they gave him insulin to take once a day, 10units at bedtime, which by bedtime his BG was 12, then back to 5 the next morning thankfuly.
Within 3 days he was brought of insulin as is BG was to low they said.

Now his BG reading on waking is 3/4
1 1/2 after lunch it's 5.5
1 1/2 after dinner it's 6

He hasn't changed in the last 4 months
His specialist has done a GAD test on him we are awaiting results
she said his average 12weeks BG was normal readings!!

Do you think he could be type 1.5 or 2

Thanks in advance

__________________
Diagnosed with Type 1 diabetes Sept 12 1977
Developed Hypoglycemic Unawareness Dec 83
8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
Lost 2 transplanted pancreas; 6/2001 & 6/2015
Longtime advocate & member of diabetes & cancer support forums for 15 yrs. A1c 5.0
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Old 07-29-2018, 19:28   #4
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A person with Type 1.5 can be on again, off again early on with insulin production, which may explain being taken off insulin. We have had some Type 2's here on the forum that were diagnosed after going to the ER and finding out they were in DKA, but ended up still being type 2. I am type 2, but I would follow Hearts Jounrey's advise and tell your son he should take the antibody tests.

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Old 07-30-2018, 17:47   #5
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Quote:
Originally Posted by Lily B View Post
Yes that is what he was told, he is slim so it is type 1
Welcome Lily. So the doc assumes that because your son is slim, he's T1. I hope your son finds another doc, seriously.

Good luck to your son.

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Old 07-30-2018, 20:32   #6
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Quote:
Originally Posted by alamogirl View Post
Welcome Lily. So the doc assumes that because your son is slim, he's T1. I hope your son finds another doc, seriously.

Good luck to your son.
Thank you alamogirl pleased to be here.x

My Son had BS of 17 when his doctor tested him, when he got to the hospital they said he had low amount ketones in his blood, they stated because of this and his age 30 and slim they said they assumed he was type 1
Within 2 days his bloods were back to normal again, he has been on no insulin/meds his bloods have stayed normal the last 4 months
Honeymoon period had been mentioned, but with no insulin you can't keep your blood sugars normal
We are awaiting GAD test result back, the first one they messed the bloods up

I'm very so confused, just want tomno what the hell is going on 😔

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Old 07-30-2018, 20:35   #7
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Hi Hearts Jounrey thank you for all your interesting and helpfully information
He has had a GAD test (2) awaiting results, next test Docs are doing a C Peptide, 4 months on I can't believe they haven't sorted this out
Thanks xxx

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Old 07-30-2018, 20:36   #8
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Thank you mbuster I will
Son is awaiting GAD results x

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Old 07-30-2018, 20:39   #9
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Lily, did you read my post above? it provides more direction

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8 grandmal seizures requiring paramedics + ER
Dx heart disease in 2000; triple bypass surgery
2 pancreas organ transplants 2001+2004 at Univ Minn & Univ Calif San Francisco med ctr
Dx with cancer twice 2007 & 2008, stage 2 & 3
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Old 07-30-2018, 21:58   #10
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Default Son's GAD test results

Quote:
Originally Posted by Hearts Jounrey View Post
Lilly i see your response above, thanks. Wonder why Dr's are not ordering C-peptide along with the other antibody tests to go along with GAD at one time so they can see the big picture and connect the pieces.

Me also HJ, Son said the doctor is waiting on the GAD test results and then doing a C peptide test, why not together I don't no
This is why I'm so confused as he is doing excellent by diet and excercise, Infact he just seems back to normal self
With normal BS readings everyday for last 4months! xx


Last edited by Lily B; 07-30-2018 at 22:07.
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