Type 2

Scientists find critical link for how obesity can cause type 2 diabetes

by Barbara Hewitt on November 30, 2017

Scientists have identified a major mechanism by which obesity causes type 2 diabetes and they hope that it could lead to the creation of new tools for risk screening.

The researchers from the University of Texas Southwestern in the United States found that in cases of obesity, insulin released into the blood by the pancreas is unable to pass through the cells that form the inner lining of blood vessels.

(Alila Medical Media/Shutterstock.com)

‘As a result, insulin is not delivered to the muscles, where it usually stimulates most of the body’s glucose to be metabolized. Blood glucose levels rise, leading to diabetes and its related cardiovascular, kidney and vision problems,’ said Dr. Philip Shaul, director of the Centre for Pulmonary and Vascular Biology in the Department of Paediatrics at UT Southwestern.

According to the study’s co-author, Dr. Chieko Mineo, associate professor of paediatrics, it was unexpected that a major problem in obesity is the delivery of circulating insulin to your muscle. ‘It was even more surprising that this problem involves immunoglobulins, which are the proteins that make up circulating antibodies,’ he added.

The researchers found that obese mice have an unexpected chemical change in their immunoglobulins. ‘The abnormal immunoglobulins then act on cells lining blood vessels to inhibit an enzyme needed to transfer insulin from the bloodstream into the muscle,’ Shaul explained.

‘Type 2 diabetes patients have the same chemical change, and if we give a mouse immunoglobulins from a type 2 diabetic individual, the mouse becomes diabetic,’ he pointed out.

He believes that the findings from the study may lead to new tools for diabetes risk screening and new avenues for diabetes prevention or treatment. The researchers identified an agent that they could administer to mice that prevents the chemical change in immunoglobulins that occurs with obesity and preserves healthy glucose status. The researchers plan to test this strategy in humans in the near future.

 

{ 0 comments }

Thumbnail image for New figures reveal the extent of heart disease risk due to type 2 diabetes

New figures reveal the extent of heart disease risk due to type 2 diabetes

September 27, 2017 Symptoms

New figures released in the UK are a stark reminder that people with type 2 diabetes have a higher risk of having a heart attack or stroke than the general population. Nearly 240,000 people with type 2 diabetes are diagnosed with heart disease or stroke in England and Wales each year, according to new estimates […]

Read the full article →
Thumbnail image for Type 2 diabetes may be transmissible, ground-breaking study suggests

Type 2 diabetes may be transmissible, ground-breaking study suggests

August 4, 2017 Diabetes General

It is possible that type 2 diabetes may be transmissible but scientist say more work is needed to find out if it really can be induced by a pancreatic protein that has gone wrong. Very early findings from a research project in the United States suggest it is worth looking at how a misfolding protein […]

Read the full article →
Thumbnail image for New generation of drugs to treat type 2 diabetes

New generation of drugs to treat type 2 diabetes

May 22, 2017 Treatment

Scientists in Australia and the United States are working on a new generation of drugs to treat diabetes aimed at helping them to avoid daily insulin injections. Two new pieces of research, described as ground breaking, aim to develop pills to treat type 2 diabetes which is a growing conditions worldwide linked to lifestyle and […]

Read the full article →
Thumbnail image for New diagnostic tool can help predict risk of diabetic kidney complications

New diagnostic tool can help predict risk of diabetic kidney complications

April 20, 2017 Treatment

Kidney complications are a risk for people with type 1 and type 2 diabetes but now scientists in the United States have develop a tool that can accurately predict some risk. The researchers from the Joslin Diabetes Centre say the test can predict the risk of end stage renal disease (ESRD) and could help with […]

Read the full article →
Thumbnail image for More people getting type 2 diabetes but they are living longer

More people getting type 2 diabetes but they are living longer

March 17, 2017 Diabetes General

The number of people in the UK with type 2 diabetes has quadrupled over the last two decades but people with the condition are living longer, according to a new study. The increase is common in many countries around the world and it is linked to rising obesity levels with this latest study from Cardiff […]

Read the full article →
Thumbnail image for Cancer drug could help combat type 2 diabetes and obesity

Cancer drug could help combat type 2 diabetes and obesity

January 27, 2016 Treatment

A drug initially designed for breast cancer could be a safe treatment for type 2 diabetes and the obesity which increases the risk of developing the condition. A team of researchers from the University of Aberdeen in Scotland made the discovery while studying the complex connections between obesity and type 2 diabetes which is an […]

Read the full article →
Thumbnail image for Here’s why catching up on sleep may help reduce the risk of type 2 diabetes

Here’s why catching up on sleep may help reduce the risk of type 2 diabetes

January 19, 2016 Diabetes General

Catching up on sleep at the weekends may help to regulate blood sugar levels and therefore reduce the risk of developing type 2 diabetes, a new study suggests. It has long been known that long term sleep deprivation can be harmful to health and linked to risk of diabetes because of how it affects the […]

Read the full article →
Thumbnail image for Research highlights link between diabetes and heart disease

Research highlights link between diabetes and heart disease

November 16, 2015 Diabetes Research Polls

Almost 3.5 million people in the UK have diabetes, an increase of over 65% in the last decade, according to a new analysis of data from family doctors, with many of them at risk from heart disease. In the past year alone there been a 3.5% rise in cases, while hundreds of thousands more people […]

Read the full article →
Thumbnail image for Scientists find type 2 diabetic drugs can have the opposite effect from intended

Scientists find type 2 diabetic drugs can have the opposite effect from intended

September 25, 2015 Treatment

A group of drugs often used to treat type 2 diabetes could actually promote the release of sugars into the blood, something they are supposed to prevent, scientists have discovered. Graham Ladds, a lecturer in pharmacology at the University of Cambridge in the UK points out that there is a continual need to evaluate and […]

Read the full article →
Thumbnail image for Dimmer switch for type 2 diabetes found in groundbreaking new research

Dimmer switch for type 2 diabetes found in groundbreaking new research

September 24, 2015 Diabetes General

Researchers in Canada have identified a molecular pathway that works like a dimmer switch which appears to be lost in type 2 diabetes. They say that the discovery is a “game changer” in terms of diabetes research as the switch adjusts how much or how little insulin is secreted when blood sugar increases. Patrick MacDonald, […]

Read the full article →