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Discussion Starter · #1 ·
Guys, I just came across this documents which claims the increased levels on Cholesterol and higher incidence of Kidney stones as a result of Ketogenic diets. Have we had these discussions in the past ?

http://www.practicalgastro.com/pdf/June06/TurnerArticle.pdf

The document links to a study done on 141 children who were put on a Ketogenic diet for management of their epilepsy

Effect of a high-fat ketogenic diet on plasma levels of... [JAMA. 2003] - PubMed - NCBI

What is your opinion on this research ? I know many of our numbers cholesterol numbers are falling but this research looks authentic and scientific ?

CONTEXT: Little prospective long-term information is available on the effect of a ketogenic diet on plasma lipoproteins in children with difficult-to-control seizures.

OBJECTIVE: To determine the effect in children with intractable seizures of a high-fat ketogenic diet on plasma levels of the major apolipoprotein B (apoB)-containing lipoproteins, low-density lipoprotein (LDL) and very LDL (VLDL); and the major apolipoprotein A-I (apoA-I)-containing lipoprotein, high-density lipoprotein (HDL).

DESIGN, SETTING, AND PATIENTS: A 6-month prospective cohort study of 141 children (mean [SD] age, 5.2 [3.8] years for 70 boys and 6.1 [4.4] years for 71 girls) with difficult-to-treat seizures who were hospitalized for initiation of a high-fat ketogenic diet and followed up as outpatients. This cohort constituted a subgroup of the 371 patients accepted into the ketogenic diet program between 1994 and 2001. A subset of the cohort was also studied after 12 (n = 59) and 24 (n = 27) months.

INTERVENTION: A ketogenic diet consisting of a high ratio of fat to carbohydrate and protein combined (4:1 [n = 102], 3.5:1 [n = 7], or 3:1 [n = 32]). After diet initiation, the calories and ratio were adjusted to maintain ideal body weight for height and maximal urinary ketosis for seizure control.

MAIN OUTCOME MEASURES: Differences at baseline and 6-month follow-up for levels of total, VLDL, LDL, HDL, and non-HDL cholesterol; triglycerides; total apoB; and apoA-I.

RESULTS: At 6 months, the high-fat ketogenic diet significantly increased the mean plasma levels of total (58 mg/dL [1.50 mmol/L]), LDL (50 mg/dL [1.30 mmol/L]), VLDL (8 mg/dL [0.21 mmol/L]), and non-HDL cholesterol (63 mg/dL [1.63 mmol/L]) (P<.001 vs baseline for each); triglycerides (58 mg/dL [0.66 mmol/L]) (P<.001); and total apoB (49 mg/dL) (P<.001). Mean HDL cholesterol decreased significantly (P<.001), although apoA-I increased (4 mg/dL) (P =.23). Significant but less marked changes persisted in children observed after 12 and 24 months.

CONCLUSIONS: A high-fat ketogenic diet produced significant increases in the atherogenic apoB-containing lipoproteins and a decrease in the antiatherogenic HDL cholesterol. Further studies are necessary to determine if such a diet adversely affects endothelial vascular function and promotes inflammation and formation of atherosclerotic lesions.
 

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Discussion Starter · #2 ·
Actually I also feel that any diet (even if it is LCHF) cannot be a 100% benign. There has to be a flip side even if it is a small flip side.

If only medical community could accept this approach (LCHF) as a genuine option for Diabetics and guide us appropriately and carefully. Thats what doctors are supposed to be doing.
 

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Wrong !!

Communist can not espouse free enterprise and still be accepted as communist.

Catholics can not espouse Protestantism and still be accepted as Catholics.

And AMA doctors can not espouse ideas like "there is a nutrition basis for disease" and still be accepted as AMA (drugs are the answer) practitioners and doing so may cost them their license in the USA.

As with any group, if you oppose their dogma you will be excommunicated, just try going to to a chess club's meeting and start advocating that they should be playing checkers instead and see what happens! :D

ColaJim


If only medical community could accept this approach (LCHF) as a genuine option for Diabetics and guide us appropriately and carefully. Thats what doctors are supposed to be doing.
 
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I can't tell from the abstracts but in every analysis of the children's epileptic ketogenic diet it's been driven home that it is nowhere near the same diet as how most adults implement it.

1. It is severely calorie restricted.
2. In the pre-formulated meals/drinks the ingredients are surprising: High in soybean oil, usually contains some HFCS, etc. Not ingredients that we normally advocate!

I can't find the composition analysis at the moment (I'll look after work) but I thought that the protein content was funky too.

Depending on how the studies were performed and the diet used, I would be wary of applying the results of pediatric ketogenic epileptic diets (which may or may not include medications too) to a diabetic or weight loss ketogenic diet.
 
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