I'd heard that the Januvia part also can severely curb your appetite due to a separate effect. If that's true, I imagine I'll gain back a large part of my appetite, but hopefully having gone low-carb, I'll have a lot fewer cravings, and also I have a good idea now of how little I can eat and still maintain my energy and health, so as long as I can put up with the hunger, I think I might be able to do better. I was previously on a combination metformin and other drug, before the doc switched me to Janumet, and I never noticed it doing anything with regard to my appetite.