I have taken Bydureon once weekly shot for 12 weeks. BG has improved 30-50 points fasting, will know A1c on Friday. I am nauseated quite a bit of the time, but it is helping me to lose weight but it is a tough road to go. The lumps at the shot sites are staying 8-10 weeks though the instructions say each shot shot will dissolve over the course of a week. Anyone else taking this? I also take 750 met ER. I had been taking 1000mg met before starting Bydureon. Would love to hear about others' experiences.