im on 200mgs of metformin and asked my dr. about the way i felt he said to cut them in half for about a week the increase 1 dose at a time until your body gets used to it. i still feel like i have zero enrgy and cant make it throu a full day with out taken a nap in the afternoon. to bad dr.s give herbal meds no credtability. im seriously thinkin about gettin off the meds and go totally natural!