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Discussion Starter · #1 · (Edited)
Currently I am on 5mg Glipizide and 5mg Farxiga which I both take in the AM. During the day it drops my levels to around 100 before lunch and 95 before dinner. That is all fine but the next day before breakfast I am in the 150-160 range. So I mentioned this to my doctor and he prescribed me yet another pill called Onglyza 5mg. I have not started taking it yet. The last thing I want is to be the guinea pig for these Pharma companies. I did a quick search on the Onglyza and it's has it's fair share of side effects. The Farxiga is already giving me side effects. Should I start taking this new pill? Does anyone have any experience with it?

Oh BTW have been on the LCHF diet for 5 days or so. That is helping as well but for some reason overnight my numbers go up. It is probably insulin resistance. I was on Metformin/Glipizide and have only recently switched. I was fed up with the side effects from the Metformin however it seems I have only traded side effects and have not got rid of them. (I dont think I ever will while taking pills)
 

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How many carbs are you down to? I have accepted that I have a monstrous dawn phenonomen and it's going to rise no matter what I eat or don't eat before going to bed. I wouldn't sweat it if it comes down quick in the am's. Mine comes down quick, my I give myself a jolt of insulin to help.

I am not doctor, but the only med (I don't call it that) for diabetes is the insulin. Because the doctor asked me if I wanted to try the newer meds and I said no.

My mother was killed by taking a common nsaid without the doctor monitoring her platelets. So that's why I'm adamant about the pills. I can only say what I would do . . . what u do take or don't take is up to you.
 

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Five days on LCHF isn't very long and it may take a few weeks or months for you to gain good control.

Seems to me your doctor is throwing a lot of meds at your diabetes. Have you been tested for GAD antibodies? To make sure you are T2 and not really T1 diabetic?

My personal opinion is that if I can't control my BG through diet, then I *might* take metformin, but probably I'd go straight to insulin. I'm not about to take anything else.
 

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BTW, since you have problems with truly high morning blood sugar (Dawn phenomenon), have you charted the timing of your meals/food eaten? I find that I do better with 6-7 hour spacing which means a small snack in the middle of my sleep cycle if I wake in the middle of it. I'm seventy so naturally I wake during the night. :) A small piece of cheese does it for me. It was a suggestion at a diabetic support group I attended.
 
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Since you take all your medication in the morning, it is reasonable to assume that your day time numbers are being influenced by the medication. Your morning number is what your BG levels actually are, give or take a few points. That said, the morning numbers are the highest for a majority of T2s, mine included, due to Dawn Phenomenon.

As far as side effects go, all of the drugs that you mentioned have pretty nasty side effects. Your Dr seems to be trying out a trial and error strategy by trying out different drugs. If you've just started on LCHF (10%C, 15%P, 75%F) give it a couple of weeks and if your numbers begin to stabilize you could look at giving up one pill after another. On LC those drugs may drop you to the lower side of normal BG, so be watchful.
 

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Discussion Starter · #7 ·
The LCHF diet is not proving too difficult. I am a carnivore so it falls in naturally. My after dinner BG was 159 last night and this morning I was at 170. So it goes up during the night without me eating anything (i guess this is normal). I am tempted to go back to the metformin and either spacing my doses apart or going with the extended release. After all, I need to do what works for me. The only reason I am on this new med is because I complained to the doctor about Metformin's side effects. My A1c was a llttle higher than it should have been at 7.3. I think that was because I cheated more than I should have and not the medication. I've always been below 7.
 

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Your HbA1c maps (crudely) to an average blood sugar over the last few months of around 160 (163 to be precise).

When we get our wake up call in the morning, our liver 'remembers' our typical figure and that's its starting point for our morning value (plus a bit since we're about to expend a lot of energy getting out of bed :))

Naturally the full picture is a lot more complicated but if you take that idea as your starting point, the solution to that morning number is to get your average day time number down from that 160.

And the answer to that? Eat to the Meter. It won't happen overnight, so don't expect it but by your next HbA1c test, you should see a significant improvement both in the HbA1c and that morning number.

As you say, the LCHF diet isn't hard for us carnivores to get into. Go for it!
 

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Discussion Starter · #9 ·
BTW, since you have problems with truly high morning blood sugar (Dawn phenomenon), have you charted the timing of your meals/food eaten? I find that I do better with 6-7 hour spacing which means a small snack in the middle of my sleep cycle if I wake in the middle of it. I'm seventy so naturally I wake during the night. :) A small piece of cheese does it for me. It was a suggestion at a diabetic support group I attended.
I had never even heard of the Dawn Phenomenon. I do not really wake up in the middle of the night except to go to the BR. I will read some more on this. Thanks
 

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I had never even heard of the Dawn Phenomenon. I do not really wake up in the middle of the night except to go to the BR. I will read some more on this. Thanks
My DP is close to 200, the other day it was actually over 200. My old liver dumps between 2 and 4. I stopped waking up and testing it. I would get up around 2 and normal, and wake at at 4 to take a thyroid pill and it higher. Then fix my breakfast, then test and it's even higher. That liver dumps glucose every two hours until I eat. And you can take a shot of insulin and it still dumps. So i wait to test til I actually eat, then take my big shot of humalog. My avg glucose is going down though. During the day it's in the 80's. So don't work too hard, i've been trying for 11 months now so I gave up because the stress drives everything up.
 

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Discussion Starter · #12 ·
I was just reading that very same article. Thanks John. What I am going to do just to see if my fasting BG improves is go back to Metformin. If it does, then I will stick with that. I suspect that my problem is insulin resistance and not the release of hormones. I have been on Metformin for 8 years now so I am used to it. I am still on the LCHF diet and I hope that with the Metformin will make my numbers more stable.
 
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