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Discussion Starter #1 (Edited)
I know I've been whinging and complaining and telling you all about my stomach woes lately. Today I finally got a diagnosis from my specialist... he reckons it's "non ulcer dyspepsia" (aka: functional dyspepsia). Basically my stomach is not moving or working properly he says. He also reckons I have a hyper-sensitive stomach and that my stomach nerves are affected. I've been put on 3 types of drugs to control symptoms... he switched the nortriptyline for sertraline instead to work on my stomach nerves. Apparently sertraline is supposed to have less side effects and it should help with control of BGLs (the other I was on doesn't). I have to increase dosage of other 2 drugs I'm on. He has let me know that hopefully my symptoms should improve and if they don't there is another drug that he has to get approval from government for which is known to cause serious side effects, mainly it puts your heart rhythm out of whack and you have to have regular ECGs if you're put on it. I don't want more drugs, especially risky ones. I want this thing to go away! I've looked it up on the net and it tells me it's a condition where symptoms come and go... well I seem to have had it everyday 24/7 for over a year now so I reckon I need a break! Does anyone else here have functional dyspepsia or know someone who does? Is there any tricks/suggestions to get rid of the symptoms? :confused: Oh, I did ask "can I get better?" the answer I got was "yes, the nerves can recover, although you have diabetes and that's unlikely"... I felt a bit miserable hearing that.... I can't stand the thought of being stuck with this thing long term... I've had enough already! He did suggest I look into everything to do with relaxation and psycho-therapy which has been known to help. He told me to stay away from stress as it makes condition worse.
 

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It must be a relief to at least know a name for it! But I doubt there's a silver bullet or magic pill.

Mayo Clinic summarizes it this way:
About Functional Dyspepsia
Functional dyspepsia refers to upper abdominal pain or discomfort not caused by any organic, systemic or metabolic disease. Because symptoms of functional dyspepsia and irritable bowel syndrome (IBS) overlap, and because patients with functional dyspepsia often also have IBS, Mayo physicians believe the two conditions may sometimes be different manifestations of the same disorder.
Doctors are still working to pinpoint the underlying causes of functional dyspepsia. Some traditional theories include:

  • Acid secretion
  • Delayed stomach emptying
  • Stiff stomach that doesn't expand easily to accommodate food
  • Hypersensitivity to stomach acid or expansion
Some newer theories include:

  • Accelerated stomach emptying
  • Abnormal responses to food by the duodenum
  • Poor coordination between the upper and lower parts of the stomach
  • Abnormal stomach contractions
  • Acute or chronic infections
  • Altered neurohormonal responses to meals
  • Abnormal processing of internal organ activity by the brain and nerves
I hope your docs monitor closely and keep up with the latest treatments . . . you really DO need a break, Mep!
 
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that's a great article.... thanks Shanny :) I am relieved somewhat that I can now call it a name... but I'm still a bit annoyed right now as I've basically been put on drugs with no timeframe on when or if I'll get better. He made it sound like I will probably get worse because of diabetes... he gave me some examples of how he has had to get diabetic patients on some surgical procedure to force emptying of their stomach which he says is often half full. It just sounded dismal to me. He commented that the current drugs available really don't do a lot for functional dyspepsia and further research is still being done... and he kept saying "I'm sorry you've been having a hard time" (he had clearly been in consult with my GP (PCD) as he kept referring to discussions he had with him about me). He has booked me in for a check in 6 months and encouraged me to keep in regular contact with my GP.
 

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That's a lot to take in at once. Getting the diagnosis and a name to it, must be a relief.

My mother has stomach issues, not to this extent, she does suffer the night time pain and gets woken every night, losing sleep, etc. She has been trying to get naps in during the day to make up for it, but even that is not enough.

I wish you the best and hope your doctors can all work together to help you. Staying away from stress is easier said then done, that's for sure. Take sometime for yourself, sounds like you definitely deserve and need it.
 
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Discussion Starter #6
thanks Eve :) I work full time so I usually can't sleep during the day. I usually try and get a sleep in on one of the weekend days. I've actually got a couple of days off work (time in lieu) this week so I'm trying to catch up on my lack of sleep. I'm feeling fatigued all the time though. I apparently have low iron level too which makes it a bit tricky as my doc doesn't like iron supplement for my stomach. I have to take it sparingly basically. My stomach obviously isn't absorbing nutrients properly, as my iron has dropped several times in past few years without usual explanations. I find my BGLs can fluctuate a lot and taking insulin can be risky at times. I'm testing a lot more lately to try and keep on top of it.
 
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Discussion Starter #7 (Edited)
some more info. I've already made it clear that I'm suspiscious that metformin was the cause or trigger of my stomach problems (I didn't have problems prior to being on metformin).
I found this interesting article: Dyspepsia
excerpt:
Some medications other than aspirin and other over-the-counter pain relievers may cause dyspepsia: alendronate (Fosamax); codeine and aspirin fortified with codeine; iron supplements; metformin (Gluco-phage); oral antibiotics, particularly erythromycin; orlistat (Xenical); corticosteroids, especially predni-sone; and theophylline. Patients should consult their doctors before discontinuing these drugs or changing the dosage.
I did notice a mistake in drugs part under "other treatments"... it is the drug 'cisapride' that is banned, not domperidone. My specialist told me about cisapride yesterday and how it can impact your heart rhythm. I'm on high dose of domperidone already.
So if you have any continuing GI side effects on metformin... please see your doc about it as it's not worth letting it trigger ongoing gastro problems.
 

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This is a good article and all of us would benefit from reading the entire commentary. Dyspepsia

Yes, metformin has a long illustrious history of causing gastric distress, at least for the first few days or weeks. If symptoms don't subside after four or five weeks, or if relief isn't forthcoming by changing to the extended release version, your doctor needs to review your chart.

Unfortunately, metformin is fairly singular in its capacity to combat insulin resistance without causing pancreas damage, so it also has a long illustrious history of being one of the safest & most effective oral diabetes drugs, not even to mention least expensive.

As I understand it, domperidone is banned in the US.
 
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Discussion Starter #9 (Edited)
I agree with you there Shanny..... it's important to stay on the safest drug for you. But I reckon I've learnt from experience and I'm probably holding some regrets in that I didn't push sooner to get off something that was making me sick. Luckily metformin is good for most people though.
I'd be really concerned about domperidone (brand name: Motilium) being banned though as I'm on the highest dosage. My specialist told me that the other, cisapride is banned here and you need govt permission to use it because it affects your heart rhythm.
I came across a couple of webpages yesterday (I'm researching as much as possible to understand what I'm dealing with... hopefully others here will find this info useful)....
Mayo clinic has the following under 'treatment':
Prokinetics
Domperidone, tegaserod or metoclopramide help increase stomach emptying or relaxation.Link: Dyspepsia Treatment - Mayo Clinic

plus I came across the following in Wiki too (I'm not sure if this is applicable in US?): Prokinetic agents would empirically seem to work well since delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia.[6] They have been shown in a meta-analysis to produce a relative risk reduction of up to 50%, but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now only available as an investigational agent[8] due to serious adverse events such as torsades, and publication bias has been cited as a potential partial explanation for such a high benefit. Link: Dyspepsia - Wikipedia, the free encyclopedia
 

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Wow, what a relief to know what you have been suffering from. Seriously, anything to do with stomach upsets and gastric problems are taboo for diabetics but they are more subjected to it. My father suffered both and aesophagitis too which became chronic and finally cancerus. Now my sister is going through the same phase and was is on treatment as she has erosions in the stomach due to long standing acidity problem. She is also heavily diabetic. I have shown your posts to her to make her understand what she is going through. After my father's death to cancer we are very careful towads our stomachs and dump a lot of probiotics for prevention. I am learning something new everyday here..thanks guys. @onlymep..I hope you will start mending now!
 
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Discussion Starter #11 (Edited)
there is something else I've been wondering about... I had 3x gastroenteritis (and docs said it would have been 3 different strains) within 3 months in 2007 and I was hospitalised twice with 2 of them because my heart rate and blood pressure went sky high. I was just coming off metformin too. So maybe combination of metformin and gastro that weakened my stomach and caused this? I've pretty much been continuously sick ever since then with all types of infections.
This is an interesting video saying there has been a study done in Canada to show that 8 years later gastroenteritis has been found to have long term effects on the stomach in some people.

 

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Does anyone ever heard about Metformin cause gas in stomach, and it cause short breath or difficulty to breath?
 
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Does anyone ever heard about Metformin cause gas in stomach, and it cause short breath or difficulty to breath?
refer to "side effects" in this link: metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com

It might be a good idea to get yourself to the doctor or a hospital to get checked as it sounds like you could possibly have lactic acidosis which is serious. Then again I don't know if you're on any other medications, etc... but I guess a doc can tell you that. I wish you the best and get help quick as better safe than sorry. :D
 

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I am very glad you have a name. Coping's nearly impossible without a diagnosis.

Sending good thoughts for solutions and relief.

(The combination of Metformin and gastroenteritis sounds suspicious to me, too.)
 
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Discussion Starter #15 (Edited)
I am very glad you have a name. Coping's nearly impossible without a diagnosis.

Sending good thoughts for solutions and relief.

(The combination of Metformin and gastroenteritis sounds suspicious to me, too.)
thanks Shalynne :)
I'm still seeing specialist about it and now waiting or a 2nd opinion... I have an appointment with gastroenterology dept in a major hospital here.... apparently they have more tests available that most gastroenterologist here have access to. So at this stage I could have my diagnosis changed. My GP reckons that "functional dyspepsia" is what they diagnose you with when they don't know what's wrong with you... he says there is always a name to whatever is happening and they've just got to find what it is. I understand that there is some major research being done on functional dyspepsia and irritable bowel syndrome to find out what the causes are... it will be interesting to see if they get any findings on that. (I think Mayo Clinic still researching). Personally I'm now starting to think it is a nerve/muscle issue at the top of my stomach as I notice every time I move it triggers pain, burping, hiccups, nausea. I've had quite a few burping & hiccup episodes together which I find very annoying.
 

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... every time I move it triggers pain, burping, hiccups, nausea. I've had quite a few burping & hiccup episodes together which I find very annoying.
It all sounds really awful, and frustrating - so sorry you're having to go through this.
 

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It might be a good idea to get yourself to the doctor or a hospital to get checked as it sounds like you could possibly have lactic acidosis which is serious. Then again I don't know if you're on any other medications, etc... but I guess a doc can tell you that. I wish you the best and get help quick as better safe than sorry. :D
Thank you for the fond reply.
However, I tried to stop Xenical this 2 nights, and it resulted the shortbreath still there right before bedtime. So, I really self-concluded that it's the met 500mg that cause it. Today and tomorrow I'll stop my after-dinner Met, and see the result.

Thanksss
 
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