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Discussion Starter · #1 ·
There is a strong consensus among the medical community that genetics play a significant role in why people become type 2 diabetics. Type 2 diabetes appears mainly in the middle age normally after the age 40. (Nowadays, many young people, some even in their teens are diagnosed type 2 but it is still an exception to the rule.) Why is it that the genes responsible for type 2 diabetes choose to "express" themselves mainly after age 40?

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Rad
 

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There is a strong consensus among the medical community that genetics play a significant role in why people become type 2 diabetics. Type 2 diabetes appears mainly in the middle age normally after the age 40. (Nowadays, many young people, some even in their teens are diagnosed type 2 but it is still an exception to the rule.) Why is it that the genes responsible for type 2 diabetes choose to "express" themselves mainly after age 40?

Regards,
Rad
That is a really good question and I will be interested in what others have to say. I was diagnosed at age 40 and my grandmother had T2 diabetes. I wasn't seeing a doctor between the ages of 30-40 and I don't remember if I had an A1C done when I was diagnosed 10+ years ago. I could have had diabetes for several years. :confused:
 

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I think many are diabetic younger...it just isnt noticed until later maybe. I was diagnosed at age 16.
 

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Genetics is HUGE in my opinion. Seems to be very hereditary
 

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Discussion Starter · #5 ·
I think many are diabetic younger...it just isnt noticed until later maybe. I was diagnosed at age 16.
Hi Onaughmae, did they do tests (like GAD antibody test) to confirm that you are type 2 and not type 1? Doctors normally tend to consider a 16 year diabetic as type 1 and proceed with type 1 treatment. Only really good doctors would go beyond this to find out if their young patient is type 1 or type 2. I think you were fortunate to have a good doctor.

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Rad
 

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Discussion Starter · #6 ·
Well... actually type 2 diabetes has a stronger genetic basis than type 1, yet it also depends more on environmental factors. Its confusing? What happens is that a family history of type 2 diabetes is one of the strongest risk factors for getting the disease but it only seems to matter in people living a Western lifestyle.
True. Type 2 has both genetic and environmental basis. But I don't think "Western lifestyle" is a major factor for many type 2 diabetics like me. Although I live in a Western country now, I don't regularly eat Western food; nor did my parents or other ancestors. We are traditionally vegetarians, cook our food from raw materials (i.e., do not normally purchase prepared food) and consume a good amount of vegetables and fruits, in addition to milk and milk products like yogurt. But my father was diabetic and three of my four older siblings are diabetic. My maternal grandmother passed away due to diabetic complications long before I was born.

Regards,
Rad
 

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Hi Onaughmae, did they do tests (like GAD antibody test) to confirm that you are type 2 and not type 1? Doctors normally tend to consider a 16 year diabetic as type 1 and proceed with type 1 treatment. Only really good doctors would go beyond this to find out if their young patient is type 1 or type 2. I think you were fortunate to have a good doctor.

Regards,
Rad
Yes, I dont have antibodies. I was *blessed* instead with extreme insulin resistance. My pancreas overworked itself to death (literally) trying to keep up. Of course, hammering it for years with pancreas stimulating drugs made it work even more into overdrive until my poor islet cells just finally gave up the ghost. According to my last c-peptide I am still producing a scant amount of insulin, but not enough to survive on with just basal body requirements.
 
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There is a strong consensus among the medical community that genetics play a significant role in why people become type 2 diabetics. Type 2 diabetes appears mainly in the middle age normally after the age 40. (Nowadays, many young people, some even in their teens are diagnosed type 2 but it is still an exception to the rule.) Why is it that the genes responsible for type 2 diabetes choose to "express" themselves mainly after age 40?

Regards,
Rad
Do they, or do they just get diagnosed then? I would suspect that weight gain and predictable "slowing of metabolism" have something to do with it. Toss in a decline in beta cell population and there you have it.
 

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I also think there are numerous "triggers" for diabetes - similar to the numerous known triggers for migraines. For women, some of those triggers are hormonal in nature - for both D & migraines. Maybe for men, too, I am not sure??

But, as to the genetic nature - this MUST be true since so many overweight people don't have D. However, there are lots of us who have no known family hx. So, it's tough to say.
 

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goldengirl, I had to dig to find my family history! The evidence was a little less direct, and still points to a combination of genes.

1) paternal uncle had thyroid disease and died in his 40's of a heart attack.

2) paternal grandmother had enormous babies. Lived to be 86, with Alz ... and had rheumatoid arthritis.

3) maternal grandfather died of a heart attack at 49.

4) maternal great-uncle was diabetic, in his 60's -- oral meds only.

5) maternal great-grandmother had "pernicious anemia," in the 1920's, and DIED of it.

So there is a relatively vague and distant evidence of CVD, and also of autoimmune disease. Maybe it is all those things, combined, in my case?

Both my parents died with Alz, my father in his late 70's, my moher at 86, and my mother and my brother have been medicated for HTN.
 
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