What is the relationship between high blood sugars and a weakened immune system? Ever since i've showed symptoms of diabetes, and found out i had it , i catch any bug that is the air and constantly fighting colds, sinus infections, etc.... I've read books, asked my drs and still confused. Before i had diabetes i had the constitution of a horse, i very seldom got sick but now it's all the time. I'm on antibiotics all the time and they very seldom are effective. Any insight into this will be greatly appreciated. "Mikey"