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Discussion Starter · #1 ·
So, wow. I got basal insulin last April and noted an increase in vivid, lucid dreaming for about a week.

Now I got rapid, and am noticing the SAME THING! Very odd ... and simply convinces me, we do not know everything about insulin's functions in the human body. AND makes me wonder ... I think I really have NEEDED more insulin.

So far so good, after 3 days -- I am LOVING being IN CONTROL of my BG, at last!!!
 

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Good for you. It does feel good when you know your BG numbers are better doesn't it? I can remember way back when....I was first on insulin after trying most of the oral medications...I could barely believe the lower numbers my meter was showing me. It was almost unbelievable. Keep up the good work :)
 

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Discussion Starter · #3 ·
Good for you. It does feel good when you know your BG numbers are better doesn't it? I can remember way back when....I was first on insulin after trying most of the oral medications...I could barely believe the lower numbers my meter was showing me. It was almost unbelievable. Keep up the good work :)
Yeah, Strawberry, it IS unbelievable ... I just look at that meter and SMILE! It is also unbelievable that it took 2 years, though ... :(
 

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Cool article ... from 1997, but informative -- see my bolding ...

Peptides (1997) 18: 1423-9.

Transport of insulin across the blood-brain barrier: saturability at euglycemic

WA Banks, JB Jaspan, W Huang, AJ Kastin

Blood-borne insulin is known to cross the blood-brain barrier (BBB) where it can act as a satiety peptide. We examined in mice the pharmacokinetics and characteristics of such passage by multiple-time regression analysis. The unidirectional influx constant (Ki) of human insulin radioactively labeled with iodine (I-Ins) ranged from 0.87 to 1.7 microliters/g-min. The transport of I-Ins was inhibited almost 50% by 0.1 micrograms/mouse of unlabeled human insulin, a dose that had no effect on serum glucose. Similar results were found with rat insulin. The results with self-inhibition suggest that any hemoencephalic signal transmitted by the blood to brain transport of insulin is independent of the effects of insulin on glucose. The transport of I-Ins was altered by aluminum but not by administration of tyrosine, verapamil, or leptin, indicating independence from amino acid transport, the p-glycoprotein system, a slow calcium channel, or leptin transport. By contrast with insulin, enzyme degradation limited the uptake and accumulation by brain of intravenously injected, radioactively labeled glucagon and glucagon-like peptide. In conclusion, these results are consistent with the view that insulin can affect satiety and related behaviors independently of its peripheral effects by crossing the BBB to act within the brain.


I am observing decreased appetite on my new dosage ... and have read others' observations they get hungry when high!
 

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I am observing decreased appetite on my new dosage ... and have read others' observations they get hungry when high!

OK Lin, Now would you agree that we can go without a meal every now and then. And at the same time to count & match without chasing the insulin? :)
 

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OK Lin, Now would you agree that we can go without a meal every now and then. And at the same time to count & match without chasing the insulin? :)
I would say that this is only true if you are using the most recent versions of insulin. The older versions, NPH as example were made to be chased and when it became time to eat you better be eating because if you didn't you were going to crash.
 
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