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Insulin in a tablet?

562 Views 3 Replies 2 Participants Last post by  mbuster
Researchers have found a way to package insulin so that it can be taken orally -- but bypassing the stomach, where acids would destroy the hormone before it was able to work.
As the tablet dissolves [between the cheek and gum], the relatively thin membrane along that area of the mouth should ideally allow the insulin to sidestep the stomach entirely and reach the liver mostly intact. And in their latest experiments with rats, the experimental delivery method appears to be working as intended. [...]

“Even after two hours of delivery, we did not find any insulin in the stomachs of the rats we tested. It was all in the liver and this is the ideal target for insulin."
Full Gizmodo article here.
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Wonder how they keep the rats from swallowing the tablet or any of it that dissolves in their mouth. I can see problems with precise dosing with this method. Maybe they got a plan.
Maybe they show the rats lots of smokeless-tobacco ads before dosing, "Just a pinch between cheek and gum..." Good question. And I don't know as this would be the transport mechanism for giving a precise dose of insulin quickly. But for daily use, I think it could have promise.
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That's what I was wondering would it come in Skoal or Copenhagen flavor, but that might invite spittin' out part of your dose. LOL
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