Wonder how they keep the rats from swallowing the tablet or any of it that dissolves in their mouth. I can see problems with precise dosing with this method. Maybe they got a plan.
Full Gizmodo article here.As the tablet dissolves [between the cheek and gum], the relatively thin membrane along that area of the mouth should ideally allow the insulin to sidestep the stomach entirely and reach the liver mostly intact. And in their latest experiments with rats, the experimental delivery method appears to be working as intended. [...]
“Even after two hours of delivery, we did not find any insulin in the stomachs of the rats we tested. It was all in the liver and this is the ideal target for insulin."