I have to eat every 3-4 hours or I feel low (and sometimes am in the low 70's) but don't have an appetite. I have no idea how I am supposed to keep this up with the metformin side effects. Mine are random nauseus spells that make fe feel terrible and what I guess is acid reflux??? I feel spit coming back up my throat ( I know, TMI). Anyway, I have been on 500 ER metformin since July 20th. The pharmacist says to give it a while longer. HOW MUCH LONGER? I just want to feel normal again........................